个人简历

教育背景： 2008.8-2013.6 清华大学生命科学学院，博士 （结构生物学） 2004.8-2008.7 北京林业大学生物科学与技术学院，学士（生物科学） 工作经历： 2013.7-2017.12 北京化工大学生命科学与技术学院，副教授 2018.1-至今 北京化工大学生命科学与技术学院，教授，博士生导师

研究领域

以X射线晶体学和冷冻电镜为手段的生物大分子结构生物学研究 1. 叶绿体分裂装置及其他蛋白质机器的分子结构与功能 2. 重要致病微生物效应蛋白的结构、致病机理研究及小分子抑制剂的筛选与设计 3. 重要酶的分子结构及基因工程改造

近期论文

1. Dong Y, Mu Y, Xie Y, Zhang Y, Han Y, Zhou Y, Wang W, Liu Z, Wu M, Wang H, Pan M, Xu N, Xu C, Yang M, Fan S, Deng H, Tan T, Liu X, Liu L, Li J, Wang J, Fang X & Feng Y*. Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature. 2018 May;557(7707):674-678
2. Gao J, Wang H, Yuan Q, Feng Y*. Structure and Function of the Photosystem Supercomplexes. Front Plant Sci. 2018 Mar 20;9:357.
3. Wang W, Li J, Sun Q, Yu X, Zhang W, Jia N, An C, Li Y, Dong Y, Han F, Chang N, Liu X, Zhu Z, Yu Y, Fan S, Yang M, Luo S, Gao H*, Feng Y*. Structural insights into the coordination of plastid division by the ARC6-PDV2 complex. Nature Plants. 2017 Mar 1;3:17011. (Selected as Hero image article, highlighted in News and Views and commented by Editorial in Nature Plants)
4. Gao S, Zhou Y, Zhang W, Wang W, Yu Y, Mu Y, Wang H, Gong X, Zheng G*, Feng Y*. Structural insights into the γ-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans. Scientific Reports. 2017 Mar 15;7:44542.
5. Li Y, Wang L, Wang G, Feng Y, Liu X. AT2G21280 only has a minor role in chloroplast division. Front Plant Sci. 2017 Dec 7;8:2095.
6. Li Y, Wang Z, Feng Y, Yuan Q. Improving trehalose synthase activity by adding the C-terminal domain of trehalose synthase from Thermus thermophiles. Bioresource Technology. 2017, in press.
7. Zhang W, Zhou Y, Wang K, Dong Y, Wang W, Feng Y*. Crystal structure of the nitrile-specifier protein NSP1 from Arabidopsis thaliana. Biochem Biophys Res Commun. 2017 Jun 17;488(1):147-152.
8. Wu K, Li W, Yu L, Tong W, Feng Y, Ling S, Zhang L, Zheng X*, Yang M*, Tian C*. Temperature-Dependent ESR and Computational Studies on Antiferromagnetic Electron Transfer in the Yeast NADH Dehydrogenase Ndi1.Physical Chemistry Chemical Physics .2017 Feb 8;19(6):4849-4854.
9. Chang N, Sun Q, Li Y, Mu Y, Hu J, Feng Y, Liu X*, Gao H. PDV2 has a dosage effect on chloroplast division in Arabidopsis. Plant Cell Rep. 2017 Mar;36(3):471-480.
10.​ Muslim R, Aftab A, Feng Y, Zahid K, Yang J, Yun W, Saleem R,Wang W, Faheem U, Yuan Q*. Biophysical and molecular docking approaches for the investigation of biomolecular interactions between amphotericin B and bovine serum albumin. J Photochem Photobiol B. 2017 Mar 23;170:6-15.
11. Liu Y, Wang W, Zhang W, Dong Y, Han F, Raza M, Liu L, Tan T* and Feng Y*. Structure of a thermostable methionine adenosyltransferase from Thermus thermophilus HB27 reveals a novel fold of the flexible loop. RSC Adv. 2016, 6, 41743
12. Zhang W, Wang W, Liu Z, Xie Y, Wang H, Mu Y, Huang Y and Feng Y*. Crystal structure of the Epithiospecifier Protein, ESP from Arabidopsis thaliana provides insights into its product specificity. Biochem. Biophys. Res. Comm. 2016, 478, 746-751
13. Li Y, Sun Q, Feng Y, Liu X*, Gao H*. An improved immunofluorescence staining method for chloroplast proteins. Plant Cell Rep. 2016, Plant Cell Rep. 2016 Nov;35(11):2285-2293
14. Chen Z, Li Y*, Feng Y, Chen L and Yuan Q*. Enzyme activity enhancement of chondroitinase ABC I from Proteus vulgaris by site-directed mutagenesis. RSC Adv., 2015,5, 76040-76047
15. Li Y, Sun X, Feng Y, Yuan Q*.Cloningexpression and activity optimization of trehalose synthase from Thermus thermophilus HB27. Chemical Engineering Science. 2015,135(2): 323–329
16. Li Y, Xuan S, Feng Y, Yan A*. Targeting HIV-1 integrase with strand transfer inhibitors. Drug Discovery Today. 2014, 12-6. Prior to 2013
17. Zhang Y, Zhao H, Wang J, Ge J, Li Y, Gu J, Li P, Feng Y, Yang M*. Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J Biol Chem. 2013, 288(30): 22058-65.
18. Li X, Zhuo W, Yu J, Ge J, Gu J, Feng Y, Yang M, Wang L*, Wang N*. Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain. Acta Crystallogr D Biol Crystallogr. 2013 Feb;69:256-65
19. Feng Y#, Li W#, Li J#, Wang J, Ge J, Xu D, Liu Y, Wu K, Zeng Q, Wu J, Tian C, Zhou B, Yang M*. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82. (# co-first author)
20. Zhang X#, Wang J#, Feng Y#, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*. Structure and mechanism of an anion-selective mechanosensitive channel of small conductance. PNAS. 2012 Oct 30;109(44):18180-5 (# co-first author)