个人简历

Education\r
Ph.D., Theoretical Organic Chemistry, 1986, University of Pittsburgh;\r
B.S., Physical Chemistry, 1981, Lanzhou University, P.R.C.\r
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Working Experience \r
2019.03- Present Executive Vice Director, Shenzhen Bay Laboratory\r
2016.03 - 2019.03 Chancellor, Peking University Shenzhen Graduate School\r
2010.09 - Present Chair Professor, College of Chemistry, Peking University Chair Professor, School of Chemical Biology & Biotechnology, PKUSZ\r
2007.07 - 2010.09 Chair Professor, Department of Chemistry, HKUST\r
2001.07 - 2010.09 Professor, Department of Chemistry, HKUST\r
1995.07 - 2001 Associate Professor, Department of Chemistry, HKUST (A-scale since 1998).\r
1992.06 - 1995.06 Lecturer/Assistant Professor, Department of Chemistry, HKUST\r
1988.06 - 1992.06 Research Associate of Prof. K. N. Houk at UCLA. Division at the National Science Foundation from June 1988 to May 1990.\r
1988.01 - 1988.05 Visiting scholar with Prof. P. v. R. Schleyer, University of Erlangen-Nürnberg, Erlangen, Germany\r
1986 - 1987 Postdoctoral with Prof. K. N. Houk at UCLA\r
1982 - 1986 Teaching Assistant and Research Assistant, University of Pittsburgh

研究领域

"""""1) small molecule inhibitor screeing based on structure and function prediction of WD40-repeat proteins. \r
2) Designing small molecules for the treatment of Alzheimer’s disease

近期论文

Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel Angew. Chem. Int. Ed. 2021, 60, 2828 – 2832 Xiaolei Huang, Shenghan Teng, Yonggui Robin Chi, Wenqiang Xu, Maoping Pu, Yun-Dong Wu, and Jianrong Steve Zhou*\r
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Iron-catalysed asymmetric carboazidation of styrenes Nat Catal. 2020, 4, 28–35 Liang Ge, Huan Zhou, Mong-Feng Chiou, Heming Jiang, Wujun Jian, Changqing Ye, Xiaoyan Li, Xiaotao Zhu, Haigen Xiong, Yajun Li , Lijuan Song, Xinhao Zhang*,  and Hongli Bao*\r
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Copper-Catalyzed Enantioselective Radical 1, 4-Difunctionalization of 1, 3-Enynes J. Am. Chem. Soc. 2020, 142, 18014–18021 Yuehua Zeng, Mong-Feng Chiou, Xiaotao Zhu, Jie Cao, Daqi Lv, Wujun Jian, Yajun Li, Xinhao Zhang*, and Hongli Bao*\r
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Computational Study on the Fate of Oxidative Directing Groups in Ru(II), Rh(III), and Pd(II) Catalyzed C-H Functionalization J. Org. Chem. 2020, 85, 12594–12602 Siqi Liu, Maoping Pu, Yun-Dong Wu*, and Xinhao Zhang*\r
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IDRMutPred: predicting disease-associated germline nonsynonymous single nucleotide variants (nsSNVs) in intrinsically disordered regions Bioinformatics, 2020, 36, 4977–4983 Jing-Bo Zhou, Yao Xiong, Ke An, Zhi-Qiang Ye,* and Yun-Dong Wu*\r
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Ru-Catalyzed Geminal Hydroboration of Silyl Alkynes via a New gem-Addition Mechanism J. Am. Chem. Soc. 2020, 142, 13867–13877 Qiang Feng, Haonan Wu, Xin Li, Lijuan Song, Lung Wa Chung*, Yun-Dong Wu*, and Jianwei Sun*\r
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Diastereo- and Enantioselective Catalytic Radical Oxysulfonylation of Alkenes in β,γ-Unsaturated Ketoximes Chem. 2020, 6, 1692–1706 Xi-Tao Li, Ling Lv, Ting Wang, Qiang-Shuai Gu, Guo-Xing Xu, Zhong-Liang Li, Liu Ye, Xinhao Zhang, Gui-Juan Cheng,* and Xin-Yuan Liu*\r
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Hybrid Palladium Catalyst Assembled from Chiral Phosphoric Acid and Thioamide for Enantioselective β‐C(sp3)-H Arylation Angew. Chem. Int. Ed. 2020, 59, 12774–12778 Hua-Jie Jiang, Xiu-Mei Zhong, Zi-Ye Liu, Rui-Long Geng, Yang-Yang Li, Yun-Dong Wu, Xinhao Zhang,* and Liu-Zhu Gong*\r
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Synthesis of ortho-Phenolic Sulfilimines via an Intermolecular Sulfur Atom Transfer Cascade Reaction Org. Lett. 2020, 22, 3799–3803 Feng Xiong,* Yingying Zuo, Yinan Song, Linxing Zhang, Xinhao Zhang,* Shaojian Xu and Yan Ren*\r
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CRiSP: accurate structure prediction of disulfide-rich peptides with cystine-specific sequence alignment and machine learning Bioinformatics. 2020, 36, 3385–3392 Zi-Lin Liu, Jing-Hao Hu, Fan Jiang* and Yun-Dong Wu*\r
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Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles Angew. Chem. Int. Ed. 2020, 59, 10814-10818 Xiaolei Huang, Minh Hieu Nguyen, Maoping Pu, Luoqiang Zhang, Yonggui Robin Chi, Yun-Dong Wu, and Jianrong Steve Zhou*\r
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Organocatalytic nitrogen transfer to unactivated olefins via transient oxaziridines Nat Catal. 2020, 3, 386–392 Qing-Qing Cheng  , Zhe Zhou  , Heming Jiang, Juha H. Siitonen, Daniel H. Ess, Xinhao Zhang  and László Kürti *\r
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Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights Adv. Synth. Catal. 2020, 362, 126 – 132 Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang,*Jiean Chen,* and Yong Huang*\r
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Computational Methods for Studying Conformational Behaviors of Cyclic Peptides[M] Fan Jiang, Hao Geng\r
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Applications of Molecular Dynamics Simulation in Structure Prediction of Peptides and Proteins Comput Struct Biotechnol J. 2019, 17, 1162-1170 HaoGeng, FangfangChen, JingYe, FanJiang*\r
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Copper-Catalyzed Radical 1,4-Difunctionalization of 1,3-Enynes with Alkyl Diacyl Peroxides and N-Fluorobenzenesulfonimide J. Am. Chem. Soc. 2019, 141, 1, 548–559 Xiaotao Zhu, Weili Deng, Mong-Feng Chiou, Changqing Ye, Wujun Jian, Yuehua Zeng, Yihang Jiao, Liang Ge, Yajun Li, Xinhao Zhang*, and Hongli Bao*\r
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Iron-catalyzed carboazidation of alkenes and alkynes Nat Commun. 2019, 10,122 Haigen Xiong, Nagarajan Ramkumar, Mong-Feng Chiou, Wujun Jian, Yajun Li, Ji-Hu SuXinhao Zhang & Hongli Bao*\r
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The reaction of alkyl hydropersulfides (RSSH, R = CH3 and Bu-t) with H2S in the gas phase and in aqueous solution Phys. Chem. Chem. Phys. 2019,21, 537-545 Linxing Zhang, Xinhao Zhang, Yun-Dong Wu,*Yaoming Xie, Jon M. Fukuto and Henry F. Schaefer III*\r
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A Missing Piece of the Mechanism in Metal-Catalyzed Hydrogenation: Co(-I)/Co(0)/Co(+I) Catalytic Cycle for Co(-I)-Catalyzed Hydrogenation Org. Lett. 2019, 21, 2, 360–364 Song-Bai Wu, Tonghuan Zhang, Lung Wa Chung*, and Yun-Dong Wu\r
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Enantioselective Addition of Cyclic Ketones to Unactivated Alkenes Enabled by Amine/Pd(II) Cooperative Catalysis ACS Catal. 2019, 9, 2, 791–797 Hong-Cheng Shen, Ling Zhang, Shu-Sen Chen, Jiajie Feng, Bo-Wen Zhang, Ying Zhang, Xinhao Zhang*, Yun-Dong Wu, and Liu-Zhu Gong*