张永鹤
近期热点
资料介绍
个人简历
北京大学基础医学院药理学系副主任北大医学部睡眠医学中心副主任兼任中国药理学会副秘书长/常务理事;中国睡眠研究会睡眠生理与药理专业委员会副主任;中国药理学会补益药专业委员会副主任;科技部863项目审评专家;科技部科技型中小企业技术创新基金评审专家;国家自然科学基金审评专家;教育部高校专家;Biomolecules & Therapeutics(SCIE) 编委;《药理学通报》编委;《药理学通讯》编委;北京市科学技术奖励评审专家。先后主持了国家自然科学基金、“重大新药创制”科技重大专项“十一五”计划-候选药物项目、教育部基金、美国中华医学基金——人才专项基金、北京大学“十五”211和985工程项目等科研项目。自1983年以来,分别从事天然药物化学,神经药理和心血管药理的研究工作。已在国内外杂志上发表论文80余篇,其中SCI收录论文60余篇,参编出版著作8本,获美国专利授权1项。研究领域
1.神经精神药理学——睡眠障碍共病(抑郁、AD、PTSD)模型建立及其神经环路机制;2.中药与天然产物新药筛选与开发近期论文
1) Huang Yuan-Li, Cui Su-Ying, Cui Xiang-Yu, Cao Qing, Ding Hui, Song Jin-Zhi, Hu Xiao, Ye Hui, Yu Bin, Sheng Zhao-Fu, Wang Zi-Jun, Zhang Yong-He*. Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms. Phytomedicine. 2016;23(14):1821-1829.2) Cao Qing, Jiang Yong, Cui Su-Ying, Tu Peng-Fei, Chen Yue-Mei, Ma Xiao-Li, Cui Xiang-Yu, Huang Yuan-Li, Ding Hui, Song Jin-Zhi, Yu Bin, Sheng Zhao-Fu, Wang Zi-Jun, Xu Ya-Ping, Yang Guang, Ye Hui, Hu Xiao, Zhang Yong-He*. Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice. Phytomedicine. 2016;23(14):1797-1805.3) Cui Su-Ying, Li Sheng-Jie, Cui Xiang-Yu, Zhang Xue-Qiong, Yu Bin, Huang Yuan-Li, Cao Qing, Xu Ya-Ping, Yang Guang, Ding Hui, Song Jin-Zhi, Ye Hui, Sheng Zhao-Fu, Wang Zi-Jun, Zhang Yong-He*. Ca2+ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats. Mol Brain. 2016;9(1):71. doi: 10.1186/s13041-016-0252-0.4) Yu Bin, Cui Su-Ying, Zhang Xue-Qiong, Cui Xiang-Yu, Li Sheng-Jie, Sheng Zhao-Fu, Cao Qing, Huang Yuan-Li, Xu Ya-Ping, Lin Zhi-Ge, Yang Guang, Song Jin-Zhi, Ding Hui, Zhang Yong-He*. Mechanisms Underlying Footshock and Psychological Stress-Induced Abrupt Awakening From Posttraumatic \ 相关热点