个人简历

2004年北京大学药学院药物化学专业博士毕业，同年在药学院化学生物学系任教至今。2010-2011年公派到法国奥尔良大学有机和分析化学系从事研究工作。主要从事单碳单位转移酶抑制剂类抗肿瘤药物的研究，以钴氨素依赖的蛋氨酸合成酶作为抗肿瘤作用的新靶点，发现了具有良好肿瘤细胞抑制作用的先导化合物。近年以第一作者和责任作者在国外SCI和国内核心杂志发表科研论文10余篇。获“一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途”中国专利授权一项。

研究领域

单碳单位转移酶抑制剂类抗肿瘤药物的研究

近期论文

1. Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang,* and Junyi Liu,* Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation. Bioorg. Med. Chem. Lett. 2013, 23, 3700. 2. Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Junyi Liu, et al, Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Euro. J. Med. Chem. 2012, 58, 228. 3. Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang*. Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate. Molecules, 2012, 17, 5604. 4. Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, et al, Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity. Eur. J. Med. Chem. 2009, 44, 764. 5. Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, et al, Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils. Synth. Commu. 2009, 39, 2310. 6. Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, et al, Synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d] pyrimidine from 2-amino-4-hydroxyl-6-methylpyrimidine J. Heterocyclic Chem., 2009, 46, 1151. 7. Jie Liu, Weidong Liu, Zhili Zhang*, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu, Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1, 2-f) pyrimidin-3-(5H)-one from 2-amino-6-methylpyrimidin-3-one, Synth. Commu. 2009, 39, 2244. 8. Jie Liu, Weidong Liu, Zhili Zhang*, Zhijian Chen, et al, Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1,2-f)pyrimidin-3-(5H)-one from 2-amino-6 -methylpyrimidin-3-one. Synth. Commun. 2009, 39, 2244. 9. Cai Tang, Zhili Zhang, Bo Xu, Min Li, Junyi Liu, Jingrong Cui.* Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro. Anti-cancer Drugs. 2008, 19, 697. 10. Zhili Zhang, Shouxin Zhou, Xiaowei Wang, Hongtao Wang, Yanli Chen, Junyi Liu*, Tetrabutylammon hydroxide: an efficient catalyst of N-alkylation of pyrimidines and purines. Chem. Res. Chinese U. 2006, 22(4), 451. 11. Zhili Zhang, Peng Han, Xiaoyan Ma, Jie Liu, Xiaowei Wang, Junyi Liu*. The benzoylation of 6-methyluracil and 5-nitro-6-methyluracil. Chin. Chem. Lett. 2005, 16(3), 287.