个人简历

教育经历: 1992 - 1995 , 理学博士 , 细胞生物学 , 北京大学生命科学学院 1989 - 1992 , 理学硕士 , 细胞生物学 , 北京大学生命科学学院 1985 - 1989 , 理学学士 , 细胞生物学 , 北京大学生物学系 工作经历: 2004 - 2005 , 访问学者 , 美国加州大学洛杉矶分校 (University of California, Los Angeles, CA)，分子、细胞与发育生物学系 2004 - 至今 , 教授 , 北京大学生命科学学院 1997 - 2002 , 博士后 , 瑞士苏黎世大学 (University of Zurich, Switzerland)，分子生物学研究所 1995 - 2004 , 副教授 , 北京大学生命科学学院 1994 - 1995 , 访问学者 , 美国威斯康星大学麦迪逊分校 (University of Wisconsin, Madison, WI)，医学院生物分子化学系

研究领域

1 以斑马鱼为模式研究脊椎动物早期胚胎发育基因表达调控与器官形成机制，特别是心血管系统以及胰腺等内脏器官的细胞分化与发育。2 斑马鱼功能基因组研究。

近期论文

1. Lu, C.-J., Fan, X.-Y., Guo, Y.-F., Cheng, Z.-C., Dong, J., Chen, J.-Z., Li, L.-Y., Wang, M.-W., Wu, Z.-K., Wang, F., Tong, X.-J., Luo, L.-F., Tang, F.-C., Zhu Z.-Y. and Zhang, B., 2018, Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Journal of Molecular Cell Biology, doi: 10.1093/jmcb/mjy064 2. Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B.* and Yang, L.*, 2016, A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa. Human Genetics, 135 (12): 1375-1387. 3. Xiao, A. and Zhang, B., 2016, Generation of targeted genomic deletions through CRISPR/Cas system in zebrafish. Methods Mol. Biol., 1451: 65-79. 4．Huang, P., Xiao, A., Tong, X., Lin, S. and Zhang, B., 2016, Targeted Mutagenesis in Zebrafish by TALENs. Methods Mol. Biol., 1338: 191-206. 5. Liu, D., Wang, Z., Xiao, A., Zhang, Y., Li, W., Zu, Y., Yao, S., Lin, S. and Zhang, B., 2014, Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized Cas9 and evaluation of off-targeting effect. J. Genet. Genomics, 41: 43-46. 6. Xiao, A., Cheng, Z., Kong, L., Zhu, Z., Lin, S., Gao G. and Zhang, B., 2014, CasOT: a genome-wide Cas9/gRNA off-target searching tool., Bioinformatics, 30 (8): 1180-1182. 7. Huang, P., Xiao, A., Tong, X., Zu, Y., Wang, Z. and Zhang, B., 2014, TALEN construction via Unit Assembly method and targeted genome modifications in zebrafish. Methods, 69 (1): 67-75. 8. Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S. and Zhang, B., 2014, Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nat. Commun., 5: 3153. 9. Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., Lin, S., 2013, TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat. Methods, 10 (4): 329-331. (Cover story) 10. Xiao, A., Wu, Y., Yang, Z., Hu, Y., Wang, W., Zhang, Y., Kong, L., Gao, G., Zhu, Z., Lin, S. and Zhang, B., 2013, EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering. Nucleic Acids Res., 41: D415-D422. 11. Wei, C., Liu, J., Yu, Z., Zhang, B., Gao, G. and Jiao, R., 2013, TALEN or Cas9 - rapid, efficient and specific choices for genome modifications. J. Genet. Genomics, 40 (6): 281-289. (Invited review) 12. Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S. and Zhang, B., 2013, Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Dev. Biol., 381 (1): 83-96. 13. Tong, X., Xia, Z., Zu, Y., Telfer H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, Lin, S. and Zhang, B., 2013, Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. J. Biol. Chem., 288 (4): 2711-2720. 14. Jiang, L., Zhang, J., Wang, J.-J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu,. M., Wang, X., Liu, F., Wu, C.-I, He, C., Zhang, B., Ci, W. and Liu, J., 2013, Sperm DNA methylome is inherited during zebrafish early embryogenesis. Cell, 153: 773-784. 15. Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S. and Zhang, B., 2013, Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic Acids Res., 41 (14): e141. 16. Huang, P., Zhu, Z., Lin, S. and Zhang, B., 2012, Reverse genetic approaches in zebrafish. J. Genet. Genomics, 39 (9): 421-433. (Invited review) 17. Huang, P., Xu, L., Liang, W., Tam, C. I., Zhang, Y., Qi, F., Zhu, Z., Lin, S. and Zhang, B., 2012, Genomic deletion induced by Tol2 transposon excision in zebrafish. Nucleic Acids Res., 41 (2): e36. 18. Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S. and Zhang, B., 2011, Heritable gene targeting in zebrafish using customized TALENs. Nat. Biotechnol., 29 (8): 699-700.