个人简历

教育经历: 1989-1993，博士，北京大学细胞生物学专业 1983-1986，硕士，南京农业大学组织学与胚胎学专业 工作经历: 2002 - 至今，北京大学生命科学学院教授 2005 - 至今，教育部长江特聘教授 1993 - 2002，北京大学生命科学学院副教授 1999 - 2002，CRC Senior Traveling Research Fellow，英国丹迪大学. 1997 - 1999，BBSRC Senior Research Fellow，英国曼彻斯特大学 1995 - 1997，Wellcome Trust Senior Traveling Research Fellow，英国丹迪大学

研究领域

1.干细胞增殖与分化； 2.细胞核结构、动态变化与功能； 3.细胞周期调控机理（包括纺锤体装配和核膜装配机理等）； 4.Ran GTP酶系统的功能调控； 5.肿瘤细胞增殖调控。

近期论文

1. Xiaowei Xu*, Shijiao Huang*, Boyan Zhang, Fan Huang, Wangfei Chi, Jingyan Fu, Gang Wang, Si Li , Qing Jiang and Chuanmao Zhang*, DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6, Nature Communication, 2017, | 8:15164 | DOI: 10.1038/ncomms15164 | 2. Huabo Chen*, Xiaowei Xu*, Guopeng Wang*, Boyan Zhang, Gang Wang, Guangwei Xin, Junjun Liu, Qing Jiang, Hongyin Zhang and Chuanmao Zhang*, CDK4 is degraded by APC/C in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells, Journal of Biological Chemistry, 2017, http://www.jbc.org/cgi/doi/10.1074/jbc.M116.773226 3. Boyan Zhang, Gang Wang, Xiaowei Xu, Sisi Yang, Tenghan Zhuang, Guopeng Wang, He Ren,Steven Y. Cheng, Qing Jiang, and Chuanmao Zhang*,DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. Journal of Biological Chemistry, 2017, 292(4): 1351–1360. 4. Junjun Liu* and Chuanmao Zhang*, The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation, Cell. Mol. Life Sci., 2017, DOI 10.1007/s00018-017-2457-5. 5. Tan Qin, Fangjin Chen, Xiaolong Zhuo, Xiao Guo, Taikangxiang Yun, Ying Liu, Chuanmao Zhang*, and Luhua Lai* Discovery of Novel Polo-Like Kinase 1 Polo-Box Domain Inhibitors to Induce Mitotic Arrest in Tumor Cells. Journal of Medicinal Chemistry, 2016, 59: 7089−7096. 6. Wanqing Du, Qian Peter Su, Yang Chen, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun*, and Li Yu,* Kinesin 1 Drives Autolysosome Tubulation. Development Cell, 2016, 37( 4):326–336. 7. Xiaowei Xu, Jia Luo, Qing Jiang, and Chuanmao Zhang*, Mitotic Spindle Assembly: The Roles of Microtubule Nucleation and Assembly, 2016, In: eLS. John Wiley & Sons, Ltd:Chichester.DOI: 10.1002/9780470015902.a0022518. 8. Shijiao Huang, Xiaowei Xu, Guopeng Wang, Guoliang Lu, Wenbing Xie, Wei Tao, Hongyin Zhang, Qing Jiang, Chuanmao Zhang*, DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. Journal of Cell Science, 2016, 129: 1429-1440 doi:10.1242/jcs.178723. 9. Boyan Zhang, Tingting Zhang, Guopeng Wang, Gang Wang, Wangfei Chi, Qing Jiang, Chuanmao Zhang* , GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis. PLoS Biology, 2015, 13(4): e1002129. doi:10.1371/journal.pbio.1002129. 10. Jingyan Fu,* Minglei Bian,* Guangwei Xin, Zhaoxuan Deng,Jia Luo,Xiao Guo, Hao Chen,Yao Wang, Qing Jiang, and Chuanmao Zhang* , TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. Journal of Cell Biology, 2015, 210 (3): 373–383. 11. Xiaolong Zhuo,* Xiao Guo,* Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu,* and Chuanmao Zhang* , Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis. Journal of Cell Biology, 2015, 210 (5): 727–735. 12. Si Li, Zhaoxuan Deng, Jingyan Fu, Caiyue Xu, Guangwei Xin, Zhige Wu, Jia Luo, Gang Wang, Shuli Zhang, Boyan Zhang, Fangdong Zou*, Qing Jiang*, and Chuanmao Zhang*, Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B. Journal of Biological Chemistry, 2015, 290(28):17546–17558. 13. Ran Q,* Nan Xu,* Gang Wang, He Ren, Si Li, Jun Lei, Qiaoyu Lin, LihaoWang, Xin Gu, Hongyin Zhang, Qing Jiang,* and Chuanmao Zhang* , The lamin-A/C–LAP2–BAF1 protein complex regulates mitotic spindle assembly and positioning. Journal of Cell Science, 2015, 128: 2830-2841. 14. Wu, Yiran、Zhuo, Xiaolong、Dai, Ziwei、Guo, Xiao、Wang, Yao、Zhang, Chuanmao*、Lai, Luhua*，Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations. Mol Biosyst, 2015, 11(2): 497-505. 15. Zhang, Meiling; Sun, Tao; Jian, Chongshu; Lei, Lei; Han, Peidong; Lv, Quanlong; Yang, Ran; Zhou, Xiaohai; Xu, Jiejia; Hu, Yingchun; Men, Yongfan; Huang, Yanyi; Zhang, Chuanmao; Zhu, Xiaojun; Wang, Xianhua; Cheng, Heping; Xiong, Jing-Wei* , Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish. PLos One, 2015, 10(7), p e0132567. 16. Gang Wang, Qing Jiang and Chuanmao Zhang*, The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. Journal of Cell Science, 2014,127:4111-4122. 17. Han, Peidong;Zhou, Xiao-Hai;Chang, Nannan;Xiao, Cheng-Lu;Yan, Shouyu;Ren, He;Yang, Xin-Zhuang;Zhang, Mei-Ling;Wu, Qing;Tang, Boyang;Diao, Ju-Peng;Zhu, Xiaojun;Zhang, Chuanmao;Li, Chuan-Yun;Cheng, Heping;Xiong, Jing-Wei*, Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Research, 2014, 24(9),1091-1107. 18. Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang*, Phosphorylation of Crm1 by CDK1–cyclin-B promotes Ran-dependent mitotic spindle assembly, Journal of Cell Science, 2013, 126 (15)：3417–3428.