个人简历
教育经历 1994.09 – 1998.07 北京医科大学，药物化学专业，本科 2000.09 – 2004.07 北京大学，药物化学专业，硕士，导师：杨铭教授 2006.09 – 2011.01 北京大学，药物化学专业，博士，导师：杨铭教授 2007.09 – 2008.09 北京大学-彼埃尔-玛丽居里大学，中法联合培养博士（留学基金委），导师：杨铭教授（中），张勇民院士（法） 工作经历 1998. 08 – 1999.07 北京医科大学，天然药物及仿生药物国家重点实验室，实习研究员 1999. 08 – 2014.07 北京大学医学部，天然药物及仿生药物国家重点实验室，助理研究员 2014. 08 – 2017.12 北京大学医学部，天然药物及仿生药物国家重点实验室，副研究员 2018. 01 – 至今 北京大学医学部，药物化学系，副研究员
研究领域
调控病毒-细胞识别的新型抗病毒药物的研究 非天然氨基酸定点修饰蛋白质的生物治疗研究； 环糊精的结构修饰及多价化在药物研发中的应用
近期论文
Liang S,# Li M,# Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem. 2019, 166, 328-338. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163, 560-568. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv. 2018, 11(4), in press. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. China-Chem.; 2018, 48(11), 589-599. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,* Xiao S.* Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates. Chin. Chem. Lett. 2018, in press Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents. Eur. J. Med. Chem. 2018, 146, 194-205 Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.* Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives. Med. Res. Rev. 2018, 38(3), 951-976. Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y, Zhou D, Xiao S.* Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity. MedChemComm. 2017, 8, 1531-1541 Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem. 2017, 35(8), 1322-1328 Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q, Zhou D.* Redirecting killer T cells through incorporation of azido sugars for tethering ligands. Chembiochem. 2017, 18(21), 2082-2086. Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y, Zhou D, Xiao S.* Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives. Molecules 2017, 22(7), 1018 Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D, Xiao S.* Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017, 134, 133-139 Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （\
