个人简历

个人简介
北京大学医学博士，北京大学生育健康研究所副所长。
主持、参与10多项国家和省部级科研课题；近年发表科研论文50余篇，其中SCI论文30余篇；参与编写专著5部；曾获中华医学科技奖、教育部科研成果奖、中华预防医学科学技术奖等多项科研奖励。

代表性科研项目
1.国家自然科学基金，胎儿中枢神经组织体细胞突变与神经管缺陷的关系研究，2018-2021，项目负责人
2.国家自然科学基金，PCP通路相关基因罕见变异及异常甲基化与胎儿无脑畸形的关联研究，2015-2018，项目负责人
3.国家自然科学青年基金，孕期母体胎盘及血叶酸受体抗体与胎儿神经管缺陷发生风险的相关性研究，2013-2015，项目负责人
4.国家重点研发计划，环境因素导致重要器官发育异常的关键环节，2016-2021，学术骨干
5.北京市自然科学基金，同源盒基因异常甲基化在神经管缺陷发生过程中的作用及机制研究，2016-2018，项目负责人
6.教育部博士点基金，孕期母体及胎儿血浆叶酸受体自身抗体与体内叶酸水平的关联性研究，2011-2013，项目负责人

研究领域

主要研究方向
分子流行病学
生育健康
营养流行病学

近期论文

10篇代表性论文
1.Huang, Y., Ren Aiguo(*); Wang Linlin(*); Jin Lei; Lin Shanshan; Li Zhiwen; McDonald, J. A. Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure, Clin Epigenetics, 2019 May 7, 11(1):72. doi: 10.1186/s13148-019-0673-6.
2.Ni Wenli; Yang Wenlei; Yu Jinhui; Li Zhiwen; Jin Lei; Liu Jufen; Zhang Yali; Wang Linlin(*); Ren Aiguo, Association between selected essential trace element concentrations in umbilical cord and risk for cleft lip with or without cleft palate: A case-control study, Science of the Total Environment, 2019.1.16, 661: 196~202
3.Lin Shanshan; Ren Aiguo(*); Wang Linlin(*); Santos Chloe; Huang Yun; Jin Lei; Li Zhiwen; Greene Nicholas, Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons, Clinical Epigenetics, 2019.1.21, 80: 1~13
4.Ni Wenlin; Yang Wenlei; Yu Jinhui; Li Zhiwen; Jin Lei; Liu Jufen; Zhang Yali; Wang Linlin(*); Ren Aiguo, Umbilical Cord Concentrations of Selected Heavy Metals and Risk for Orofacial Clefts, Environmental Science Technology, 2018.9.18, 52(18): 10787~10795
5.Lin Shanshan; Ren Aiguo(*); Wang Linlin(*); Huang Yun; Wang Yuanyuan; Wang Caiyun; Greene Nicholas, Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects, Free Radical Biology and Medicine, 2018.02.20, 116: 149~158
6.Tian Tian; Wang Linlin(*); Shen Yan; Zhang Bo; Finnell Richard H.; Ren Aiguo(*), Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects, Epigenomics, 2018.07, 10(7): 891~901
7.Ni Wenli; Tian Tian; Zhang Le; Li Zhiwen; Wang Linlin(*); Ren Aiguo, Maternal periconceptional consumption of sprouted potato and risks of neural tube defects and orofacial clefts, Nutrition Journal, 2018.11.28, 17(1): 112
8.Wang Linlin; Lin Shanshan; Zhang Ji; Tian Tian; Jin Lei; Ren Aiguo(*), Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis, Epigenetics, 2017.1.6, 12(2): 157~165
9.Wang Linlin; Mei Zuguo; Li Hongtian; Zhang Yali; Liu Jianmeng(*); Serdula Mary K., Modifying effects of maternal Hb concentration on infant birth weight in women receiving prenatal iron-containing supplements: a randomised controlled trial, British Journal of Nutrition, 2016.2.28, 115(4): 644~649
10.Wang Linlin; Li Zhiwen(*); Jin Lei; Li Kai; Yuan Yue; Fu Yunting; Zhang Yali; Ye Rongwei; Ren Aiguo(*), Indoor air pollution and neural tube defects: effect modification by maternal genes, Epidemiology, 2014.7.23, 25(5): 658~665
社会兼职：
中国妇幼保健协会出生缺陷防治与分子遗传分会委员；
中华预防医学会全国出生缺陷预防与控制青年委员；
北京营养学会理事；
中国医药教育协会健康管理专业委员会秘书长。