个人简历
教育部长江学者、特聘教授，博士生导师。1988年毕业于北京医科大学并获博士学位。1988-1997年留学剑桥大学和耶鲁大学从事博士后研究。1997-2005年在美国惠氏制药公司,任首席研究员从事神经精神疾病的新药研发。2005年回国，获得了国家自然科学重点、面上基金、科技部863、973以及教育部创新团队、培育基金等多项基金的支持。长期以来从事离子通道的结构与神经生物学的功能研究和神经精神疾病的创新药物研发。
研究领域
离子通道的结构与神经生物学、药理学功能 离子通道是所有细胞电活动的物质基础。神经细胞离子通道的功能异常，可导致癫痫、神经离子通道作为神经细胞兴奋性的物质基础是神经科学领域研究的主要焦点之一。神经细胞离子通道的功能异常，可导致癫痫、神经病理痛、抑郁症和学习与记忆障碍等神经和精神疾病。通过电生理记录、分子生物学和生物化学为手段并结合X-线晶体结构技术为发展核心，旨在揭示离子通道的结构及其神经生物学的生理和病理功能，并最终将研究成果用于生物靶点鉴别、筛选方法的建立和研发治疗神经系统疾病的创新药物。
近期论文
1. Wen Xu, Yuwei Wu, Yeping Bi, Lei Tan, Yehua Gan and KeWei Wang (2010)“Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats”, Mol Pain 6:49 2. Ping Liang, Hao Chen, Yuanyuan Cui, and KeWei Wang？ (2010) “Functional Rescue of Kv4.3 Channel Tetramerization Mutants by KChIP4a”, Biophys J 98:12 3. Fan Yang, Yuanyuan Cui, KeWei Wang and Jie Zheng (2010) “Is the pore turret just thermoTRP channels’ appendix?” PNAS 107 (32) E126-E127; published ahead of print July 21, 2010, doi:10.1073/pnas.1008504107 4. Fan Yang, Yuanyuan Cui, KeWei Wang and Jie Zheng (2010) “Thermosensitive TRP Channel Pore Turret Is Part of the Temperature Activation Pathway”,PNAS, 107(15):7083-7088 5. Yu-wei Wu Ye-Ping Bi,2 Xiao-Xing Kou, Wen Xu, Li-Qun Ma, Ke-Wei Wang,Ye-Hua Gan, Xu-Chen Ma (2010) “17-β-estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through upregulation of Hippocampal TRPV1 in Ovariectomized Rats”, J Neurosci 30(26)8710-9719 6. Ying Zhang, Ping Su, Ping Liang, Tao Liu, Xu Liu, Xin-Ying Liu, Bo Zhang, Tao Han, Yan-Bing Zhu, Dong-Min Yin, Jun-Fa Li, Zhuan Zhou, Ke-Wei Wang, and Yun Wang (2010) “The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit”, J Neurosci 30 (22):7525-7586 7. Ping Liang, Huayi Wang, Hao Chen, Yuanyuan Cui, Lichuan Gu, Jijie Chai, and KeWei Wang？ (2009) “Structural insights into KChIP4a modulation of Kv4.3 inactivation” J Biol Chem. 284 (8): 4960-7 8. KeWei Wang (2008) “Modulation by clamping: Kv4 and KChIP interactions” Neurochemical Research ,(10):1964-69 9. Yuanyua Cui, Ping Liang and KeWei Wang？ (2008) Enhanced trafficking of tetrameric Kv4.3 channels by KChIP1 clamping. Neurochemical Research (10):1964-69 10. KeWei Wang and Jijie Chai. (2009) Invited book chapter: “Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels”. Wiley Publisher (New York) 11. Huayi Wang, Yan Yan, Qun Liu, Yanhua Huang, Yue Shen, Linjie Chen, Yi Chen, QiuyueYang, Quan Hao, KeWei Wang？ and Jijie Chai. (2007) Structural Basis for Modulation of Kv4 K+ Channels by Auxiliary KCHIP Subunits. Nature Neuroscience, 10 (1): 32-39 12. Flora Jow, Eugene Tseng,, Taney Maddox, Ru Shen, Dianne Kowal, John Dunlop, Belew Mekonnen and KeWei Wang？ (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by R-L3 benodiazepine compound, Assay & Drug Dev Technologies 4(4):443-450 13. Flora Jow, Lan He, Angela Kramer, Joe Hinson, Mark R. Bowlby, John Dunlop and KeWei Wang？ (2006) Validation of DRG-like F11 cells for evaluation of KCNQ/M-channel modulators, Assay & Drug Dev Technologies 4(1):235-242. 14. KeWei Wang？, Beal McIlvain, Eugene Tseng, Dianne Kowal, Flora Jow, Ru Shen, Howard Zhang, Qin Jennifer Shan and John Dunlop (2004) Validation of an atomic absorption Rb+ efflux assay for KCNQ/M-channels using the Ion Channel Reader (ICR) 8000, Assay & Drug Dev Technologies 2 (5):525-534 15. F. Jow, Z.H. Zhang, D.C. Kopsco, K.C. Carroll, K.W. Wang？ (2004) Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/？1.1 K+ channels, PNAS 101 (43):15535-15540 16. Robert H. Scannevin, KeWei Wang？, Flora Jow, Jennifer Megules, David C. Kopsco, Wade Edris, Karen C. Carroll, Qiang Lü, Weixin Xu, Zhangbao Xu, Alan H. Katz, Stephane Olland, Laura Lin, Meggin Taylor, Mark Stahl, Karl Malakian, Will Somers, Lydia Mosyak, Mark R. Bowlby, Pranab Chanda, and Kenneth J. Rhodes, (2004) Two N-terminal domains of Kv4 channels regulate binding to and modulation by KChIP1, Neuron 41:587-598
