个人简历

孙育杰，北京大学生命科学学院生物动态光学成像中心（BIOPIC）研究员，博士生导师，基金委杰出青年基金获得者，第三届Elsevier Scopus Young Scientist Award，Bayer Investigator, 中国化学学会生物物理化学专业委员会委员,中国细胞生物学学会细胞器生物学分会委员,中国生物物理学会单分子生物学专业委员会委员,中国仪器仪表学会显微仪器分会副理事长,中国电子显微镜学会共聚焦专业委员会副主任,美国细胞生物学会国际事务委员会委员。本科和硕士毕业于中国科大化学系，2005年美国匹兹堡大学化学博士，宾夕法尼亚大学肌肉研究所和纳米/生物交叉研究中心博士后。2011年初加入北京大学生物动态光学成像中心，致力于运用单分子、超高分辨率荧光成像及操纵技术研究细胞结构与功能的关系教育经历: 博士 美国 University of Pittsburgh Department of Chemistry 1999-2005 硕士 中国科学技术大学 化学系 1997-1999 学士 中国科学技术大学 应用化学系 1992-1997工作经历: 2013-至今 研究员　　 北京大学生命科学学院生物动态光学成像中心(BIOPIC)，膜生物学国家重点实验室 2011-2013 副研究员 北京大学生命科学学院生物动态光学成像中心(BIOPIC) 2005-2010 博士后　　 Pennsylvania Muscle Institute & Nano/Bio Interface CenterUniversity of Pennsylvania

研究领域

1. 单分子生物物理 2. 超分辨成像 3. 分子马达 4. 染色质结构与动态过程

近期论文

1. Shipeng Shao, Lei Chang, Yuao Sun, Yingping Hou, Xiaoying Fan, Yujie Sun, `Multiplexed sgRNA Expression Allows Versatile Single Non-repetitive DNA Labeling and Endogenous Gene Regulation`, ACS Synthetic Biology, accepted 2. Multicolor Photo-Crosslinkable AIEgens towards Compact Nanodots for Subcellular Imaging and STED Nanoscopy, Small，accepted 3. Chen X, Liu Z, Li R, Shan C, Zeng Z, Xue B, Yuan W, Mo C, Xi P, Wu C, Sun Y., “Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots.”, ACS Nano. 2017 doi: 10.1021/acsnano.7b02893. 4. Shipeng Shao, Lei Chang, Yingping Hou, Yujie Sun, “Illuminating the structure and dynamics of chromatin by fluorescence labeling”, Front. Biol. DOI 10.1007/s11515-017-1454-2 5. Wang S, Ding M, Chen X, Chang L, Sun Y. “Development of bimolecular fluorescence complementation using rsEGFP2 for detection and super-resolution imaging of protein-protein interactions in live cells.”, Biomed Opt Express. 2017, 8(6):3119-3131. 6. Zhucheng Chen, Ruifang Guan, Lei Zhang, Qian Su, Keith mickolajczyk, Geng-Yuan Chen, William Hancock, Yujie Sun, and Yongfang Zhao, “Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin”, Nature Comm. 2017, 8:14951 7. Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J., “Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.”, Nat Commun. 2017, 8:14639. 8. Xuanze Chen, Rongqin Li, Zhihe Liu, Kai Sun, Zezhou Sun, Danni Chen, Gaixia Xu, Peng Xi, Changfeng Wu,* & Yujie Sun*, “Photoblinking small semiconductor polymer dots for fluorescence nanoscopy”, Adv. Mater. 2017, 29(5). doi: 10.1002/adma.201604850. (*co-corresponding, VIP paper & cover story) 9. Hu H, Zhang H, Wang S, Ding M, An H, Hou Y, Yang X, Wei W, Sun Y, Tang C., “Live visualization of genomic loci with BiFC-TALE”, Sci. Rep. 2017, 7:40192. 10. Burgess S, Cheng L, Gu F, Huang J, Huang Z, Lin S, Li J, Li W, Qin W, Sun Y, Songyang Z, Wei W, Wu Q, Wang H, Wang X, Xiong JW, Xi J, Yang H, Zhou B, Zhang B., “Questions about NgAgo”, Protein Cell 2016, 7(12):913-915. 11. Sheng Wang, Xuanze Chen, Lei Chang, Ruiying Xue, Haifeng Duan, and Yujie Sun, “GMars-Q Enables Long-Term Live-Cell Parallelized Reversible Saturable Optical Fluorescence Transitions Nanoscopy”, ACS Nano 2016, 10:9136–9144 (cover story) 12. Shen M, Zhang N, Zheng S, Zhang WB, Zhang HM, Lu Z, Su QP, Sun Y, Ye K, Li XD, “Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor”, Proc. Natl. Acad. Sci. USA 2016, 113(40):E5812-E5820. 13. Xuanze Chen, Zhiping Zeng, Rongqin Li, Boxin Xue, Peng Xi* and Yujie Sun*, “Superior performance with sCMOS over EMCCD in Super-resolution Optical Fluctuation Imaging (SOFI)”, J. Biomed. Optics 2016, 6:066007 (*co-corresponding) 14. Pu Y, Zhao Z, Li Y, Zou J, Ma Q, Zhao Y, Ke Y, Zhu Y, Chen H, Baker MA, Ge H, Sun Y, Xie XS, Bai F, “Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells”, Mol Cell. 2016, 62(2):284-94. 15. Xuanze Chen, Weijian Zong,Rongqin Li, Zhiping Zeng, Jia Zhao, Peng Xi, Liangyi Chen and Yujie Sun, “Two-photon light-sheet nanoscopy by fluorescence fluctuation correlation analysis”, Nanoscale 2016, 8: 9982–9987. 16. Wanqing Du, Qian Peter Su, Yang Chen, Yueyao Zhu, Dong Jiang, Yueguang Rong, Senyan Zhang, Yixiao Zhang, He Ren, Chuanmao Zhang, Xinquan Wang, Ning Gao, Yanfeng Wang, Lingfei Sun, Yujie Sun* and Li Yu*, “Kinesin 1 Drives Autolysosome Tubulation”, Dev. Cell 2016, 37: 326–336 (*co-corresponding) 17. Qian Peter Su, Wanqing Du, Qinghua Ji, Boxin Xue, Dong Jiang, Yueyao Zhu, Jizhong Lou, Li Yu*, and Yujie Sun*, “Vesicle Size Regulates Nanotube Formation in the Cell”, Sci. Rep. 2016, 6:24002 (*co-corresponding) 18. Xuanze Chen, Mian Wei, M. Mocarlo Zheng, Jiaxi Zhao, Huiwen Hao, Lei Chang, Peng Xi, and Yujie Sun, “Study of RNA Polymerase II Clustering insideLive-Cell Nuclei Using Bayesian Nanoscopy”, ACS Nano 2016, 10: 2447–54. 19. Shipeng Shao, Weiwei Zhang, Huan Hu, Boxin Xue, Jinshan Qin, Chaoying Sun, Yuao Sun, Wensheng Wei, Yujie Sun, “Long-term Dual-color Tracking of Genomic Loci by Modified sgRNAs of the CRISPR/Cas9 System”, Nucleic Acids Res. 2016, 44: e86