个人简历

2013 – Visiting Professor, Dana Farber Cancer Institute, Harvard Medical School 2011 - Visiting Professor, PKUSZ 2010 - 2012 Adjunct Professor, HKUST 2007, 2009 Visiting Professor, HKUST 2007 Visiting Professor, University of California, San Francisco 2005 -Professor of Chemistry and Biochemistry, University of Notre Dame 2001 - 2005 Associate Professor of Chemistry and Biochemistry, University of Notre Dame 2000 -Consultant to pharmaceutical industry 1999 -Founding Member, Walther Cancer Research Center 1996 - 2001 Assistant Professor of Chemistry and Biochemistry, University of Notre Dame 1993 - 1995 Postdoctoral Fellow with Prof. Dr. K. N. Houk, UCLA 1991 - 1993 Dr. rer. nat. (Ph.D.), with Prof. Dr. E. Steckhan, University of Bonn (Germany) 1990 - 1991 Diplom (M.S.), with Prof. Dr. E. Steckhan University of Bonn (Germany)

研究领域

"Organic Chemistry"Computer Aided Drug Design: Virtual Screening; Computational Enzymology; Cheminformatics; QSAR Epigenetic Control of Gene Expression in Cancer: HDACs and Bromodomains Small-Molecule Treatments of Metabolic and Neurodegenerative Diseases, especially Niemann Pick Type C Systems Biology Approaches to Antibiotic Drug Discovery (Staph. aureus) and to rare diseases Organic and Metalorganic Reaction Mechanism, especially prediction of stereoselectivity Entrepreneurship in Drug Discovery & Chemical Biology"Computational and Physical Organic Chemistry, Computational Drug Design, Biophysical Chemistry, Enzyme Mechanisms, Transition Metal Catalyzed Reactions and Design of Ligands for Enantioselective Catalysis
"

近期论文

1. K. Chen, L. Xu, O. Wiest “Zinc Binding Groups for HDAC Inhibition” J. Org. Chem. 2013, 78, 5051–5055 2. B. E. Haines, C. N. Steussy, C. V. Stauffacher, O. Wiest “Molecular Modeling of the Reaction Pathway and Hydride Transfer Reactions of HMG-CoA Reductase” Biochemistry, 2012, 51, 7983-7995 3. J. Lee, P. Helquist, O. Wiest “Diastereoselectivity in Lewis-Acid-Catalyzed Mukaiyama Aldol Reactions: A DFT Study” J. Am. Chem. Soc. 2012, 134, 14973–14981 4. O. Wiest, P. Helquist “Striking a Balance to Control Stereochemistry” Science 2011, 333, 1831-1832 5. H. Pipalia, C. C. Cosner, A. Huang, A. Chaterjee, P. Bourbon, N. Farley, P. Helquist, O. Wiest, F. R. Maxfield “Histone deacetylase (HDAC) inhibitor treatment dramatically reduces cholesterol accumulation in lysosomal storage organelles of Niemann-Pick Type C1 human fibroblasts” Proc. Natl. Acad. Sci. 2011, 108, 5620-5625 6. Y. Shen, J. Liu, G. Estiu, B. Isin, D-S. Lee, A-L. Barabási, V. Kapatral, O. Wiest, Z. N. Oltvai “A blueprint for antimicrobial hit discovery targeting metabolic networks” Proc. Natl. Acad. Sci. 2010, 107, 1082-1087 7. P. Filippakopoulos, J. Qi, S. Picaud, Y. Shen, W. B. Smith, O. Fedorov, E. M. Morse, T. Keates, T. T. Hickman, I. Felletar, M. Philpott, S. Munro, N. West, M. J. Cameron, T. Heightman, N. LaThangue, A. Kung, C. A. French, O. Wiest, S. Knapp, J. E. Bradner “Selective Inhibition of BET Bromodomains” Nature 2010, 468, 1067-1073