个人简历

教育经历: 2002 - 2008，理学博士，进化生物学，芝加哥大学 1999 - 2002，理学硕士，遗传学，北京大学 1995 -1999，理学学士，细胞生物学和遗传学，北京大学 工作经历: 2013 - 至今，研究员，北京大学生命科学学院 2008 - 2013，博士后，康奈尔大学分子生物学和遗传学系

研究领域

A central tenet in evolutionary biology is to decipher the genotype-phenotype relationships and the underlying evolutionary driving force. Our long-term goal seeks to elucidate how gene expression architecture evolves to cause phenotypic changes and environmental adaptation at the systems level. The advent of high-throughput sequencing-based functional genomics provides us with an unprecedented opportunity to address many fundamental issues related to gene expression regulation and evolution. Our research team at Peking University take an integrative genomics approach to dissect the molecular mechanisms and evolutionary principles of translational control, with a focus on the evolution and functions of the cis- and trans-acting elements and their interactions in translational regulation.

近期论文

1. Zhang H #, Wang YR #, Li J, Chen H, He XL, Zhang HW, Liang H*, Lu J* (2018). Biosynthetic Energy Cost for Amino Acids Decreases in Cancer Evolution. Nature Communications. 9(1):4124. doi: 10.1038/s41467-018-06461-1. 2. Zhang H#, Dou SQ#, He F, Luo JJ, Wei LP, and Lu J* (2018). Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development. PLoS Biology. 16(7):e2003903. doi: 10.1371/journal.pbio.2003903. 3. Luo S#, He F#, Luo J#, Dou S#, Wang Y#, Guo A, Lu J* (2018). Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response. Nucleic Acids Research. 46(10):5250-5268. 4. Luo J#, Wang Y#, Yuan J#, Zhao Z, Lu J* (2018). MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution. RNA. 24(6):787-802. 5. Duan Y#, Dou S#, Zhang H#, Wu C, Wu M, Lu J* (2018). Linkage of A-to-I RNA editing in metazoans and the impact on genome evolution. Mol Biol Evol. 35(1):132-148. 6. Luo S, Lu J* (2017). Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective. Genomics Proteomics & Bioinformatics. 15(3):164-176. 7. Duan Y#, Dou S#, Luo S#, Zhang H, Lu J* (2017). Adaptation of A-to-I RNA editing in Drosophila. PLoS Genetics. 13(3):e1006648. 8. Wang YR, Luo JJ, Zhang H, and Lu J* (2016) microRNAs in the same clusters evolve to coordinately regulate functionally related genes. Molecular Biology and Evolution 33(9):2232-47. 9. Zhang XY, Zhu Y, Liu XD, Hong XY, Xu Y, Zhu P, Shen Y, Ji YS, Wen X, Zhang C, Zhao Q, Wang YC, Lu J, Guo HW*. (2015) Suppression of endogenous gene silencing by degradation of normal cytoplasmic RNA in Arabidopsis. Science 348(6230): 120-123. 10. Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, Sun C, Yang J, Yang Z, Yang X, Lu J, Xi JJ*. (2016) Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nature Communications. 7:11012. doi: 10.1038/ncomms11012. 11. Ye KX, Lu J, Ma F, Keinan A, Gu ZL*. (2014) Extensive Pathogenicity of Mitochondrial Heteroplasmy in Healthy Human Individuals. Proceedings of the National Academy of Sciences 111(29): 10654–10659. 12. Lu J* & Clark AG* (2012). Impact of microRNA regulation on variation in human gene expression. Genome Research. 22(7): 1243–1254. 13. Zhou RC, Ling SP, Zhao WM, Osada N, Chen SF, Zhang M, He ZW, Bao H, Zhong CR, Zhang B, Lu XM, Turissini D, Duke NC, Lu J*, Shi SH*, Wu CI* (2011) Population genetics in non-model organisms: II. Natural selection in marginal habitats revealed by deep sequencing on dual platforms. Molecular Biology and Evolution 28(10):2833-42. 14. Tang T, Kumar S, Shen Y, Lu J, Wu ML, Shi S, Li WH, Wu CI* (2010) Adverse interactions between micro-RNAs and target genes from different species. Proceedings of the National Academy of Sciences 107: 12935-12940. 15. Lu J, Clark AG* (2010). Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila. Genome Research 20: 212-227. 16. Lu J, Shen Y,Wu QF, Kumar S, He B, Carthew RW, Wang SM*, Wu CI* (2008). The birth and death of microRNA genes in Drosophila. Nature Genetics 40: 351-355; author reply in 42: 9-10. 17. Lu J, Fu Y, Kumar S, Shen Y, Zeng K, Xu A, Carthew RW, Wu CI* (2008). Adaptive evolution of newly emerged micro-RNA genes in Drosophila. Molecular Biology and Evolution 25: 929-938. 18. Wang HY, Fu Y, McPeek MS, Lu X, Nuzhdin S, Xu A, Lu J, Wu ML, Wu CI* (2008). Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions. Proceedings of the National Academy of Sciences 105: 6362-6367.