个人简历

1982年7月毕业于陕西中医学院药学系获学士学位；1989年至1994年在中国药科大学攻读硕博连读研究生，1993年至1994年在日本国富山医科药科大学留学，1994年7月在中国药科大学获得博士学位；1994年9月至1996年8月在北京医科大学药学院博士后站作科研工作，1996年9月博士后出站留校；1997年聘为副研究员和研究生导师，现在北京大学药学院从事中药和天然药物研究工作。

研究领域

1. 中药新药与新剂型研究 2. 天然药物活性成分与质量评价研究 3. 中药复方药效物质研究

近期论文

[1]. Qingrong Fu, HongWang, YuexiangLan,SenLi, Yuki Hashi,, Shizhong Chen*. High- throughput and sensitive screening of compounds with deoxyribonucleic acid-binding activity by a high-performance liquid chromatography–tandem mass spectrometry-fluorescence detection technique using palmatine as a fluorescence probe. Journal of Chromatography A, 1323 (3):123–124,2014. [2]. Zhiling Song, Hong Wang, Biao Ren, Baobao Zhang, Yuki Hashi, Shizhong Chen*. On-line study of flavonoids of Trolliuschinensis Bunge binding to DNA with ethidium bromide using a novel combination of chromatographic, mass spectrometric and fluorescence techniques.Journal of Chromatography A, 1282(22):102–112, 2013. [3]. Zongtao Lin, Hong Wang, Qingrong Fu, Yi Liang, Baobao Zhang, Yuki Hashi, Shizhong Chen*. Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumulanelumbinis using On-line HPLC-UV coupled with ESI-IT-TOF-MS and BchE biochemical detection Talanta 2013，110 (15):180-189. [4]. HaijuanAn, HongWang, Yuexiang Lan, Yuki Hashi, Shizhong Chen*. Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of ApocynumvenetumL.leaves by HPLC–DAD–ESI–IT–TOF–MS and HPLC–DAD. Journal of Pharmaceutical and Biomedical Analysis, 85(11): 295–304, 2013. [5]. YaruNiu, Liangliang Yin, ShihengLuo, Jing Dong, Hong Wang,,YukiHashi, Shizhong Chena*. Identification of the Anti-oxidants in FlosChrysanthemi by HPLC–DAD–ESI/MSn and HPLC Coupled with a Post-column Derivatisation System. Phytochemical Analysis. 2013. 24 (1): 59-68. [6]. ZhilingSong , Yuki Hashi, Hongyang Sun, Yi Liang, YuexiangLan,Hong Wang,,Shizhong Chen*. Simultaneous determination of 19 flavonoids in commercial trollflowers by using high-performance liquid chromatography and classification of samples by hierarchical clustering analysis.Fitoterapia 91(11) : 272–279. 2013. [7]. Zongtao Lin, Hong Wang, Ying Xu, Jing Dong, Yuki Hashi, Shizhong Chen*, Identification of antioxidants in Fructusaurantiiand its quality evaluation using a new on-line combination of analytical techniques,Food Chemistry, 134(2):1181–1191, 2012. [8]. YaruNiu, Hui Li, Jing Dong, Hong Wang, Yuki Hashi, Shizhong Chen*. Identification of isoflavonoids in Radix Puerariae for quality control using on-line high performance liquid chromatography-diode array detector-electrospray ionization-mass spectrometry coupled with post-column derivatization. , 48 (2): 528–537,2012. [9]. Gang Cui, YaruNiu, Hong Wang, Jing Dong, Hashi Yuki, Shizhong Chen*. Rapid Isolation and Identification of Active Antioxidant Ingredients from Gongju Using HPLC-DAD-ESI-MSn and PostcolumnDerivatization. Journal of Agriculture and Food Chemistry, 60 (21): 5407？5413,2012. [10]. Yi Liang, Gang Cui, Xiaoxue Wang, Wei Zhang, QuanAn, Zongtao Lin, Hong Wang*,Shizhong Chen*. Pharmacokinetics of honokiol after intravenous guttae in beagle dogs assessed using ultra-performance liquid chromatography–tandem mass spectrometry. Biomedical chromatography, doi 10.1002/bmc. 3179. [11]. Guo-Qiang Liu, Jing Dong, Hong Wang, Yuki Hashi, Shi-Zhong Chen*. Comparison of Two species of Notopterygium by high-performqnce liquid chromatography- photodiode array detection-electrospray ionization tanswm mass spectrometry.European Journal of Mass Spectrometry, 18(1): 59-60, 2012. [12]. Guoqiang Liu, Jing Dong, Hong Wang, Yuki Hashi,Shizhong Chen*. Characterization of alkaloids in SophoraflavescensAit.by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry.Journal of Pharmaceutical and Biomedical Analysis,54 (5): 1065–1072, 2011. [13]. Guo-Qang Liu，Jing Dong, Hong Wang, Yuki Hashi , Shi-Zhong Chen*. Differentiation of four pairs of furocoumarinisomers by electrospray ionization tandem mass spectrometry. European Journal of Mass Spectrometry, 16 (2):215-220,2010. [14]. Hui Li，Leren Wan，Yuki Hashi，Shizhong Chen*. Fragmentation study of a 8-C-glycosyl isoflavone, puerarin, using electrospray ion trap time-of-flight mass spectrometry at high resolution. Rapid Commun.MassSpectrom. 2007, 21 (15): 2497–2504. [15]. Liangliang Yin, Jing Dong, Hashi Yuki,,, Shizhong Chen*. Online Identification of Flavones from FlosChrysanthemi LC–MS-IT-TOF LC GC Europe, 2009, Oct 9,Special Issues.