个人简历

教育经历: 2003.09-2008.09　　Doctor of Philosophy major in Biological Physics, University of Oxford 2010.04-2010.05　　Visiting Scholar, Virginia Polytechnic Institute and State University 2004.09-2004.12　　Visiting Scholar, The University of California at Berkeley 1999.09-2003.06　　Bachelor of Science, Peking University, Department of Physics 工作经历: 2014.09-present　　Assistant Professor, PI 2011.08-2014.08　　Assistant Professor, Co-PI with Professor Sunney Xiaoliang Xie. 2009.09-2011.08　　JSPS Postdoctoral research fellow, Osaka University 2008.09-2009.09　　IRC and EPSRC Postdoctoral research fellow, University of Oxford

研究领域

研究方向一：单细胞基因测序技术应用于癌症病人外周血循环肿瘤细胞研究，深入探索癌症转移的分子生物学机制及通过循环肿瘤细胞测序进行无创癌症诊断、预后判断、疗效评价的临床方法。研究方向二：大样本基因测序研究癌症发生、转移机制。针对明确的临床问题，采用基因测序手段研究中国人群高发癌症的基因突变特征，发掘引起癌症表型转化、转移的关键驱动事件。研究方向三：综合使用基因测序、荧光成像手段研究细菌行为、致病性，抗生素杀菌原理和细菌抗药、耐药的分子机制。

近期论文

25. Jiang Y,...Bai F, Wang P*, Shi L*, Huang W*, Shao Z*, Genomic and transcriptomic landscape of triple-negative breast cancers: subtypes and treatment strategies, (2019), Cancer Cell, (in press) 24. Su z, Wang Z, Ni X, Duan J, Gao Y, Zhuo M, Li R, Zhao J, Ma Q, Bai H, Chen H, Wang S, Chen X, An T, Wang Y, Tian Y, Yu J, Wang D, Xie X*, Bai F*, Wang J*, Inferring evolution and progression of small-cell lung cancer by single-cell sequencing of circulating tumor cells, (2019), under review 23. Zhang J#, Chen H#, Li R, Yao G, Bai F*, Xing J*, Spatial clustering and common regulatory elements correlate with coordinated gene expression, (2019), PLOS Computational Biology (in press) 22. Fujimaki K#, Li R#, Chen H, Della Croce K, Zhang H, Xing J, Bai F*, Yao G*, A lysosomal dimmer switch regulates cellular quiescence depth, https://www.biorxiv.org/content/early/2018/09/10/413989 (2018), under review 21. Zhao H, Tian X, He L, Li Y, Pu W, Liu Q, Tang J, Wu J, Cheng X, Liu Y, Zhou Q, Tan Z, Bai F, Xu F, Smart N, Zhou B*, Apj+ vessels drive tumor growth and represent a tractable therapeutic target, Cell Reports 25 (2018), pp. 1241-1254 20.Li Z#,Li S#,Li R#, Zhu H, Guo X, Mu L, Cai J, Bai F*, Chen G*, Hong D*, Leukaemic alterations of IKZF1 prime stemness and malignancy programs in human lymphocytes, Cell Death and Disease 9 (2018), pp. 526 (*corresponding author) 19.Liu M#, Liu Y#, Deng L#, Wang D, He X, Zhou L, Wicha M, Bai F*, Liu S*, Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer, Molecular Cancer 17(2018), pp. 65 (*corresponding author) 18.Xue R, Li J, Bai F, Wang XW, Ji J, Lu Y, A Race to uncover a panoramic view of the liver cancer genome, Cancer Biol Med (2018), in press doi: 10.20892/j.issn.2095-3941. 2017.0112. 17.Liu M#, Liu Y#, Di J#, Su Z, Yang H, Jiang B, Wang Z, Zhuang M, Bai F*, Su X*, Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer, BMC Cancer 17 (2017), pp.787 (*corresponding author) 16.Li R#, Li X#, Xue R#, Yang F#, Wang S, Li Y, Shen D, Sun K, Chen K, Weng W, Bai F*, Wang J*, Early metastasis detected in patients with multifocal pulmonary ground-glass opacities (GGOs), Thorax 73 (2018), pp. 290-292(*corresponding author) 15.Li Y, Wu S, Bai F*, Molecular characterization of circulating tumor cells—from bench to bedside, Seminars in Cell & Developmental Biology 75 (2018), pp. 88-97(*corresponding author) 14.Chen X#, Yan S#, Liu Y#, Zhong Q#, Chen Z#, Jin S#, Xia T, Li R, Zhou A, Su Z, Huang Y, Huang Q, Huang L, Zhang X, Zhao Y, Yun J, Wu Q, Lin D, Bai F*, Zeng M*, Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole exome sequencing, Nature Communications 8 (2017), pp.524 doi: 10.1038/s41467-017-00650-0(*corresponding author) 13.Li J#, Liu K#, Chen H#, Li R, Drechsler M, Bai F*, Huang J*, Tang B*, Yan Y*, Functional build-in template directed siliceous fluorescent supramolecular vesicles as diagnostics, ACS Applied Materials & Interfaces 9 (2017), pp. 21706-21714(*corresponding author) 12.Fang Y#, Su Z#, Xie J#, Xue R, Ma Q, Lu X, Wang X, Wen C, Shi M, Tang X, Chen H, Zhan Q, Li H, Deng X, Peng C, Bai F*, Shen B*, Genomic signatures of adenosquamous carcinoma of pancreas in Chinese population，Journal of Pathology 243 (2017), pp. 155-159(*corresponding author) Highlighted by Invited Commentaries `Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas` of the same issue 11.Gao Y#, Ni X#, Guo H#, Su Z#, Ba Y#, Tong Z, Guo Z, Yao X, Chen X, Yin J, Yan Z, Guo L, Liu Y, Bai F*, Xie S*, Zhang N*, Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumour cells, Genome Research 27 (2017), pp. 1312-1322(*corresponding author) 10. Du Y#, Li R#, Chen Z#, Wang X, Xu T*, Bai F*, Mutagenic factors and complex clonal relationship of multifocal urothelial cell carcinoma, European Urology 71 (2017), pp. 841–843 (*corresponding author) 9. Xue R, Li R, Zhang N*, Bai F*, Understanding intra-tumor heterogeneity and tumor evolution to facilitate hepatocellular carcinoma therapy, Translational Cancer Research 3 (2016), pp. S604-S605 (*corresponding author) 8. Xue R#, Li R#, Guo H#, Guo L#, Su Z, Ni X, Qi L, Zhang T, Li Q, Zhang Z, Xie XS, Bai F*, Zhang N*, Variable extent of intra-tumor heterogeneity revealed by genomic sequencing of multiple lesions in patients with hepatocellular carcinoma, Gastroenterology 150 (2016), pp. 998-1008 (*corresponding author) Highlighted by Editorial `Heterogeneity among liver cancer-a hurdle to optimizing therapy` of the same issue, Highlighted by `The genetic heterogeneity of hepatocellular carcinoma and the implications for personalised medicine` Translational Cancer Research 5,(Suppl 1):S1-S4 (2016).