个人简介
1965年9月生,浙江慈溪人。1988年7月毕业于上海中国人民解放军第二军医大学,获医学学士学位。1996年6月在南京中国药科大学获药物分析学博士学位。1997年3月至1999年3月在南京大学化学博士后流动站开展生物微量检测新方法的研究工作。现为中国人民解放军第二军医大学药学院药物分析学教研室主任,全军药物分析学重点实验室、上海市药物(中药)代谢产物研究重点实验室和上海市药物代谢研究中心(中药代谢研究方向)的学科带头人;兼任中国药学会高级会员,上海市药理学会药代动力学专业委员会副主任委员,上海市药学会药物分析专业委员会委员、秘书,全军药物分析专业委员会副主任委员。
研究领域
长期从事现代药物(中药)分析学、药物(中药)代谢动力学的教学和科研工作,在生物药物分析、手性药物分析、药物代谢分析与中药配伍分析以及现代宏量分离制备与微分离分析新技术新方法等方面有较深入的研究。
近期论文
1. Chen Wang, Jiangrui Zhou, Shuowen Wang, Mingliang Ye, Chunlei Jiang, Guorong Fan, Hanfa Zou.Combined comparative and chemical proteomics on the mechanisms of levo- tetrahydropalmatine-induced antinociception in the formalin test. J Proteome Res,2010, 9(6): 3225–3234. (通讯作者, 2009IF 5.132) 2. Chen Wang, Jiangrui Zhou, Shuowen Wang, Mingliang Ye, Guorong Fan, Hanfa Zou, Chunlei Jiang. Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes. Toxicol Lett,2010, 194:8-15. (通讯作者, 2009IF 3.479) 3. Chen Wang, Shuowen Wang, Guorong Fan, Hanfa Zou, Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem, 2010, 396:1731-1740. (通讯作者, 2009IF 3.48) 4. Hua Wei, Jun Wen, Rui Xie, Houwen Lin, Guorong Fan, Yutian Wu, Quantitative determination of Phakellistatin 13, a new cyclic heptapeptide, in rat plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. Anal Bioanal Chem, 2009, 395:1461-1469. (通讯作者, 2009IF 3.48) 5. Ning Sun, GuoCai Lu, Mei Lin, Guorong Fan, Yutian Wu, High-throughput quantification of a novel thiazolidinedione MCC-555 in rat plasma by ultra-fast liquid chromatography and its application in pharmacokinetic studies. Talanta, 2009,78:506-512. (通讯作者, 2009IF 3.29) 6. Lingli Zhang, Jun Wen, Yaju Pan, Zhen Li, Guorong Fan, Yutian Wu, Determination of ulifloxacin, the active metabolite of prulloxacin, in human plasma by a 96-well format solid-phase extraction and capillary zone electrophoresis. J Chromatogra. B., 2008, 872:172-176. (通讯作者, 2009IF 2.777) 7. N Jia, X Liu, Jun Wen, LY Qian, XH Qian, Yutian Wu, Guorong Fan, A proteomic method for analysis of CYP450s protein expression changes in carbon tetrachloride induced male rat liver microsomes. Toxicology, 2007, 237: 1-11. (通讯作者, 2009IF 3.241) 8. Tingting Zhou, Bin Chen, Guorong Fan, Yifeng Chai, Yutian Wu, Application of high-speed counter-current chromatography coupled with high-performance liquid chromatography-diode array detection for the preparative isolation and purification of hyperoside from Hypericum perforatum with on-line purity monitoring. J Chromatogr A, 2006, 1116:97-101. (通讯作者, 2009IF 4.101) 9. Jinyong Peng, Guorong Fan, Yutian Wu, Preparative isolation of four new and two known flavonoids from the leaf of Patrinia villosa Juss. by counter-current chromatography and evaluation of their anticancer activities in vitro. J Chromatogr A, 2006, 1115:103-111. (通讯作者, 2009IF 4.101) 10. Tingting Zhou, Guorong Fan, Zhanying Hong, Yifeng Chai, Yutian Wu, Large-scale isolation and purification of geniposide from the fruit of Gardenia jasminoides Ellis by high-speed counter-current chromatography. J Chromatogr A, 2005, 1100:76-80. (通讯作者, 2009IF 4.101) 11. Xin Zhou,Jinyong Peng, Guorong Fan, Yutian Wu, Isolation and purification of flavonoid glycosides from trollius ledebouri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase. J Chromatogr A,2005, 1092:216-221. (通讯作者, 2009IF 4.101)