个人简历

科研项目：
NDRG1在血管损伤后新生内膜形成中的作用及其分子机制 国家自然基金面上项目(81370227) 2014.01—2017.12 65万
甲基苯丙胺（METH）致动脉夹层发生机制及防治 广州科技计划项目（201707010302） 2017.05—2020.04 20万

研究领域

毒品损伤分子机制； 心血管疾病分子机制""

近期论文

Zhu LN, Qiao HH, Chen L, Sun LP, Hui JL, Lian YL, Xie WB, Ding JY, Meng YL, Zhu BF*, Qiu PM*. (2018) SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine.Front Cell Neurosci. 24;12:262. [PMID:30197588]
Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H*, Xie WB*.(2018) CDK5-mediated Tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicology Letters, 292:97-107. [PMID:29705343]
Xu X, Huang E, Luo B, Cai D, Zhao X, Luo Q, Jin Y, Chen L, Wang Q, Liu C, Lin Z, Xie WB*, Wang H*. (2018) Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells through activating C/EBPβ related signaling pathway. The FASEB Journal, in press, [PMID:29939784]
Li L, Chen S, Wang Y, Yue X, Xu J, Xie WB, Qiu P, Liu C, Wang A*, Wang H*. (2017) Role of GSK3β/α-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells. Toxicol Res (Camb). 7(2):221-234. [PMID:30090577]
Du SH, Qiao DF, Chen CX, Chen S, Liu C, Lin Z, Wang H*, Xie WB*. (2017)Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes. Frontiers in Molecular Neuroscience, 10:409. [PMID:29311802]
Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H*, Xie WB*. (2017) Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Frontiers in Molecular Neuroscience, 10:203. [PMID: 28694771]
Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. (2017) Effects of DDIT4 in methamphetamine-induced autophagy and apoptosis in dopaminergic neurons. Molecular Neurobiology, 54:1642-1660. [PMID: 26873849]
Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB*, Wang H*. (2016). Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death and Disease, 7:e2161. [PMID: 27031958]
Chen R, Wang B, Chen L, Chen C, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. (2016). DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicology and Applied Pharmacology, 295:1-11. [PMID: 26825372]
Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. (2016). Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology Letters, 240:149-160. [PMID: 26524635]
Hu ZY, Xie WB, Yang F, Xiao LW, Wang XY, Chen SY*, Li ZG*. (2015) NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling. Biochim Biophys Acta. 1852(9):1876-86. [PMID: 26071641]
Huang W, Xie WB, Qiao D, Qiu P, Huang E, Li B, Liu C, Wang Q, Lin Z, Wang H*. (2015)Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicological Sciences, 145:68-79. [PMID: 25631491]
Leung KP, Qu YH, Qiao DF, Xie WB, Li DR, Xu JT, Wang HJ*, Yue X*. (2014) Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes.Mol Med Rep. 10(5):2306-12. [PMID:25230843]
Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB*, Wang H*. (2014). Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicology Letters, 230:444-453. [PMID: 25127757]
Wu XF, Wang AF, Chen L, Huang EP, Xie WB, Liu C, Huang WY, Chen CX, Qiu PM*, Wang HJ*.(2014) S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.Toxicol Lett. 230(1):19-27. [PMID: 25090657]
Yang X, Liu Y, Liu C, Xie WB, Huang E, Huang W, Wang J, Chen L, Wang H, Qiu P, Xu J, Zhang F, Wang H*. (2013) Inhibition of ROCK2 expression protects against methamphetamine-induced neurotoxicity in PC12 cells.Brain Res. 1533:16-25. [PMID: 23954743]
Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY*. (2013) Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells.Circ Res. 113(8):e76-86. [PMID: 23817199]
Shi N, Xie WB, Chen SY*. (2012) Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation. J Biol Chem. 287(9):6860-7. [PMID: 22223649]
Huang WY, Xie WB, Guo X, Li F, Jose PA, Chen SY*. (2011) Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells.Am J Physiol Cell Physiol. 301(2):C499-506. [PMID: 21613609]
Li Z, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY*. (2011) Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.J Biol Chem. 286(48):41323-30. [PMID: 21990365]
Wang JN, Shi N, Xie WB, Guo X, Chen SY*. (2011) Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.Arterioscler Thromb Vasc Biol. 31(8):e19-26.
Xie WB, Li Z, Miano JM, Long X, Chen SY*. (2011) Smad3-mediated myocardin silencing: a novel mechanism governing the initiation of smooth muscle differentiation.J Biol Chem. 286(17):15050-7. [PMID: 21402709]