个人简历

王国栋，博士，研究员，博士生导师
1996年毕业于南开大学化学系，1999年获中科院上海药物研究所有机化学硕士学位，2003年获中科院上海植物生理生态研究所植物分子遗传学博士学位。2003年11月至2006年12月，在美国UniversityofMichigan(AnnArbor)进行博士后研究工作；2006年底－2009年5月，在美国SamuelRobertsNobleFoundation工作，长期从事植物特异性代谢研究。2009年六月，入选中国科学院“百人计划”，中科院遗传发育所研究员。

研究领域

研究方向：植物功能代谢组学"研究方向
实验室集中于解析植物来源的重要小分子代谢物的代谢途径/酶促反应机理及其生物学功能研究，并对高附加值的代谢物进行合成生物学应用研究。
1.植物代谢组分析方法建立优化：植物产生超过30万种代谢物(代谢物多样性)，这些代谢物在植物的生活史中，特别是与环境适应、物种间互作，发挥着重要的生理作用，但具体分子机制大多不明确。首先，为全面定性定量了解这些化合物在植物体内的变化规律，我们已建立技术齐备的色质联用化学分析平台（见下图；参考DOI:10.16288/j.yczz.19-122），将针对不同的生物学问题，利用不同的检测平台/方法获取需要的“化学表型”信息。
2.植物重要代谢途径解析和生物学功能研究：我们利用代谢组学，基因组学和转录组学等现代组学技术手段，结合传统的分子和生化技术解析植物中重要代谢物的合成途径及其调控，同时利用合成生物学的技术策略将从植物中所解析的代谢途径在酵母体系中重组优化，大规模生产对人体健康有益的小分子代谢物（主要集中于萜类化合物）。在研项目包括：
a，大豆籽粒营养物质（大豆皂苷，异黄酮，维他命E和氨基酸等）生物合成途径及调控，长期应用目标是培育营养品质优良的“个性化”大豆新品系；
b，拟南芥新型萜类物质（C25，二倍半萜）和NAD补救合成途径，长期研究目标探究植物如何利用代谢网络（新化合物）调控微生物群落组成，实现植物根际“合成生态学”设计理念；
c，啤酒花腺毛萜酚类化合物生物合成和转运过程的解析，长期应用目标以酵母和番茄为底盘，利用合成生物学技术手段，培育符合市场需求萜酚类化合物产品。"

近期论文

1.He,J.,Chen,Q.,Xin,P.,Yuan,J.,Ma,Y.,Wang,X.Xu,M.,Chu,J.,PetersR.,andWang,G*.(2019)CYP72Aenzymescatalyse13-hydrolyzationofgibberellins.NaturePlantsDOI:10.1038/s41477-019-0511-z.(CoverStory)
2.Liu,L.,Zhang,F.,Li,G.,andWang,G*.(2019)QualitativeandquantitativeNAD+metabolomicsleadstodiscoveryofmultiplefunctionalnicotinateN-glycosyltransferaseinArabidopsis.Front.PlantSci.10,1164.
3.Xie,P.,Shi,J.,Tang,S.,Chen,C.,Khan,A.,Zhang,F.,Xiong,Y.,Li,C.,He,W.,Wang,G.,Lei,F.,Wu,Y.,andXie,Q.(2019)Controlofbirdfeedingbehaviorbytannin1throughmodulatingthebiosynthesisofpolyphenolsandfattyacid-derivedvolatilesinSorghum.MolPlantDOI:10.1016/j.molp.2019.08.004.
4.Bian,X.,Li,W.,Niu,C.,Wei,W.,Hu,Y.,Han,J.,Lu,X.,Tao,J.,Jin,M.,Qin,H.,Zhou,B.,Zhang,W.,Ma,B.,Wang,G.,Lai,Y.,Chen,S.,andZhang,J.(2019)AclassBheatshockfactorselectedforduringsoybeandomesticationcontributestosalttolerancebypromotingflavonoidbiosynthesis.NewPhytolDOI:10.1111/nph.16104.
5.Gao,S.,Xiao,Y.,Xu,F.,Gao,X.,Cao,S.,Zhang,F.,Wang,G.,Sanders,D.,andChu,C.(2019)Cytokinin-dependentregulatorymoduleunderliesthemaintenanceofzincnutritioninrice.NewPhytol224,202-215.
6.Chen,Q.,Jiang,T.,Liu,YX.,Liu,H.,Zhao,T.,Liu,Z.,Gan,X.,Hallab,A.,Wang,X.,He,J.,Ma,Y.,Zhang,F.,Jin,T.,Schranz,ME.,Wang,Y.,Bai,Y.*,andWang,G*.(2019)Recentlyduplicatedsesterterpene(C25)geneclustersinArabidopsisthalianamodulaterootmicrobiota.SciChinaLifeSci62,947-958.
7.Zhou,J.,Wang,X.,Wang,M.,Chang,Y.,Zhang,F.,Ban,Z.,Tang,R.,Gan,Q.,Wu,S.,Zhang,Q.,Wang,F.,Zhao,L.,Jing,Y.,Qian,W.,Wang,G.,Guo,W.*,andYang,C.*(2018)Aberrantlysinecatabolismdisruptsmitochondrialhomeostasisessentialforanimaldevelopment.JCellBiol218,580-597.
8.Wu,R.,Zhang,F.,Liu,L.,Li,W.,Pichersky,E.,andWang,G.*(2018)MeNA,controlledbyreversiblemethylationofnicotinate,isaNADprecursorthatundergoeslong-distancetransportinArabidopsis.MolPlant10,1264-1277.
9.Ding,L.,Yang,X.,Tian,H.,Liang,J.,Zhang,F.,Wang,G.,Wang,Y.,Ding,M.,Shui,G.,andHuang,X.*(2018)Mitochondrialcalcium-dependentmetabolismsupportsSeipin-mediatedlipidhomeostasis.EMBOJ37,e97572.
10.Ban,Z.,Qin,H.,Mitchell,A.J.,Liu,B.,Zhang,F.,Weng,J.K.,Dixon,R.A.*,andWang,G.*(2018)Non-catalyticchalconeisomerase-foldproteinsinHumuluslupulusareauxiliarycomponentsinprenylatedflavonoidbiosynthesis.ProcNatlAcadSciUSA115,E5223-E5232.(CoverStory)
11.Du,L.,Xu,F.,Fang,J.,Gao,S.,Tang,J.,Fang,S.,Wang,H.,Tong,H.,Zhang,F.,Chu,J.,Wang,G.,andChu,C.*(2018)EndospermsugaraccumulationcausedbymutationofPHS8/ISA1leadstopre-harvestsproutinginrice.PlantJ95,545-556.
12.Yang,Y.,Zhang,Y.,Zhang,S.,Chen,Q.,Ma,K.,Bao,L.,Tao,Y.,Yin,W.,Wang,G.,andLiu,H.*(2018).Identificationandcharacterizationofamembrane-boundsesterterpenecyclasefromStreptomycessomaliensis.JNatProd81,1089-1092.
13.Zhao,Y.,Luo,L.,Xu,J.,Xin,P.,Guo,H.,Wu,J.,Bai,L.,Wang,G.,Chu,J.,Zuo,J.,Yu,H.*,Huang,X.*,andLi,J.*(2018).MalatetransportedfromchloroplasttomitochondriontriggersproductionofROSandPCDinArabidopsisthaliana.CellRes28,448-461.
14.Li,W.,Zhang,H.,Li,X.,Zhang,F.,Liu,C.,Du,Y.,Gao,X.,Zhang,Z.,Zhang,X.,Hou,Z.,Zhou,H.,Sheng,X.,Wang,G.,andGuo,Y.*(2017).Integrativemetabolomicandtranscriptomicanalysesunveilnutrientremobilizationeventsinleafsenescenceoftobacco.SciRep7,12126.
15.Fang,C.#,Ma,Y.#,Wu,S.#,LiuZ.,Wang,Z.,Yang,R.,Hu,G.,Zhou,Z.,Yu,H.,Zhang,M.,Pan,Y.,Zhou,G.,Ren,H.,Du,W.,Yan,H.,Wang,Y.,Han,D.,Shen,Y.,Liu,S.,Liu,T.,Zhang,J.,Qin,H.,Yuan,J.,Yuan,X.,Kong,F.,Liu,B.,Li,J.,Zhang,Z.*,Wang,G.*,Zhu,B.*,andTian,Z.*(2017).Genome-wideassociationstudiesdissectthegeneticnetworksunderlyingagronomicaltraitsinsoybean.GenomeBiol18,161.
16.Li,W.#,Zhang,F.#,Wu,R.#,Jia,L.,Li,G.,Guo,Y.,Liu,C.,andWang,G.*(2017)AnovelN-methyltransferaseinArabidopsisappearstofeedaconservedpathwayfornicotinatedetoxificationamonglandplantsandisassociatedwithligninbiosynthesis.PlantPhysiol174,1492-1504.
17.Shao,J.,Chen,Q.,Lv,H.,He,J.,Liu,Z.,Lu,Y.N.,Liu,H.*,Wang,G.*,andWang,Y.*(2017).(+)-Thalianatrieneand(-)-RetigeraninBcatalyzedbysesterterpenesynthasesfromArabidopsisthaliana.OrgLett19,1816-1819.
18.Yang,X.,Nian,J.,Xie,Q.,Feng,J.,Zhang,F.,Jing,H.,Zhang,J.,Dong,G.,Liang,Y.,Peng,J.,Wang,G.,Qian,Q.,andZuo,J.(2016).Riceferredoxin-dependentglutamatesynthaseregulatesnitrogen-carbonmetabolomesandisgeneticallydifferentiatedbetweenjaponicaandindicasubspecies.MolPlant9,1520-1534.
19.Li,Q.,Fang,C.,Duan,Z.,Liu,Y.,Qin,H.,Zhang,J.,Sun,P.,Li,W.,Wang,G.,andTian,Z.*(2016).FunctionalconservationanddivergenceofGmCHLIgenesinpolyploidsoybean.PlantJ88,584-596.
20.Wei,G.,Tian,P.,Zhang,F.,Qin,H.,Miao,H.,Chen,Q.,Hu,Z.,Cao,L.,Wang,M.,Gu,X.,Huang,S.,Chen,M.,andWang,G.*(2016).Integrativeanalysesofnon-targetedvolatileprofilingandtranscriptomedataprovidemolecularinsightintoVOCdiversityincucumberplants(CucumissativusL.).PlantPhysiol172,603-618.
21.Wang,C.,Chen,Q.,Fan,D.,Li,J.,Wang,G.*,andZhang,P.*(2016).Structuralanalysesofshort-chainprenyltransferasesidentifyanevolutionarilyconservedGFPPScladeinBrassicaceaeplants.MolPlant9,195-204.(CoverStory)
22.Li,W.,Zhang,F.,Chang,Y.,Zhao,T.,Schranz,M.E.,andWang,G.*(2015).NicotinateO-glucosylationisanevolutionarilymetabolictraitimportantforseedgerminationunderstressconditionsinArabidopsisthaliana.PlantCell27,1907-1924.
23.Chen,Q.,Fan,D.,andWang,G.*(2015)Heteromericgeranyl(geranyl)diphosphatesynthaseisinvolvedinmonoterpenebiosynthesisinArabidopsisflowers.MolPlant8，1434-1437.
24.Wang,B.,Chu,J.,Yu,T.,Xu,Q.,Sun,X.,Yuan,J.,Xiong,G.,Wang,G.,Wang,Y.,andLi,J.*(2015).Tryptophan-independentauxinbiosynthesiscontributestoearlyembryogenesisinArabidopsis.ProcNatlAcadSciUSA112,4821-4826.
25.Li,H.,Ban,Z.,Qin,H.,Ma,L.,King,A.J.,andWang,G.*(2015).Aheteromericmembrane-boundprenyltransferasecomplexfromHumuluslupuluscatalyzesthreesequentialaromaticprenylationsinthebitteracidpathway.PlantPhysiol167,650-659.
26.Wang,G.*(2015).LC-MSinPlantMetabolomics.InQiXeds.PlantMetabolomics:MethodsandApplications.SpringerNetherlands,pp45-61
27.Wang,G.*(2015).ApplicationsofLC-MSinPlantMetabolomics.InQiXeds.PlantMetabolomics:MethodsandApplications.SpringerNetherlands,pp213-226
28.Wang,G.*(2014).Recentprogressinsecondarymetabolismofplantglandulartrichomes.PlantBiotech31,353-361.
29.Xu,F.,Fang,J.,Ou,S.,Gao,S.,Zhang,F.,Du,L.,Xiao,Y.,Wang,H.,Sun,X.,Chu,J.,Wang,G.,andChu,C.*(2014).VariationsinCYP78A1codingregioninfluencegrainsizeandyieldinrice.PlantCellEnviro38,800-811.
30.Song,Q.,Li,Q.,Liu,Y.,Zhang,F.,Ma,B.,Zhang,W.,Man,W.,Du,W.,Wang,G.,Chen,S.,Zhang,J.*(2013).SoybeanGmbZIP123geneenhanceslipidcontentintheseedsoftransgenicArabidopsisplants.JExpBot64,4329-4341.
31.Zhao,N.,Wang,G.,Norris,A.,Chen,X.,andChen,F.*(2013).Studyingplantsecondarymetabolismintheageofgenomics.CritRevPlantSci32,369–382.
32.Yu,S.,Cao,L.,ZhouC.,ZhangT.,Lian,H.,Sun,Y.,Wu,J.,Huang,J.,Wang,G.,andWangJ.*(2013).Sugarisanendogenouscueforjuvenile-to-adultphasetransitioninplants.eLife2,e00269.
33.Xu,H.,Zhang,F.,Liu,B.,Huhman,DV.,Sumner,LW,Dixon,RAandWang,G.*(2013).Characterizationoftheformationofbranchedshort-chainfattyacid:CoAsforbitteracidbiosynthesisinhopglandulartrichomes.MolPlant6,1301–1317.
34.Yu,H.,Zhang,F.,Wang,G.,Liu,Y.,andLiu,D.*(2013)Partialdeficiencyofisoleucineimpairsrootdevelopmentandalterstranscriptlevelsofthegenesinvolvedinbranched-chainaminoacidandglucosinolatemetabolisminArabidopsis.JExpBot64,599-612.
35.Yu,H.,Du,X.,Zhang,F.,Hu,Y.,Liu,S.,Jiang,X.,Wang,G.,andLiu,D.*(2012).AmutationintheE2subunitofthemitochondrialpyruvatedehydrogenasecomplexinArabidopsisreducesplantorgansizeandenhancestheaccumulationofaminoacidsandintermediateproductsoftheTCAcycle.Planta236,387-399.
36.Liu,X.,…Wang,G.,…Li,C.*(2012).ActivationofthejasmonicacidpathwaybydepletionofthehydroperoxidelyaseOsHPL3revealscrosstalkbetweentheHPLandAOSbranchesoftheoxylipinpathwayinrice.PLoSOne7,e50089.
37.Wu,H.J.,…Wang,G.D.,…Xie,Q.*(2012).InsightsintosalttolerancefromthegenomeofThellungiellasalsuginea.ProcNatlAcadSciUSA109,12219-12224.
38.Li,C.,Wang,Y.,Liu,L.,Hu,Y.,Zhang,F.,Mergen,S.,Wang,G.,Schl？ppi,M.R.,andChu,C.*(2011).Ariceplastidialnucleotidesugarepimeraseisinvolvedingalactolipidbiosynthesisandimprovesphotosyntheticefficiency.PLoSGenet7,e1002196.
39.Tan,H.,Yang,X.,Zhang,F.,Zheng,X.,Qu,C.,Mu,J.,Fu,F.,Li,J.,Guan,R.,Zhang,H.,Wang,G.andZuo,J.*(2011).EnhancedseedoilproductionincanolabyconditionalexpressionofbrassicanapusLEAFYCOTYLEDON1(BnLEC1)andLEC1-LIKE(BnL1L)indevelopingseeds.PlantPhysiol156,1577-1588.
40.Dai,X.,Wang,G.,Yang,DS.,Tang,Y.,Broun,P.,Marks,MD.,Sumner,LW.,Dixon,RA,andZhaoPX.*(2010).TrichOME:acomparativeomicsdatabaseforplanttrichomes.PlantPhysiol152,44-54.
41.Wang,G.,andDixon,RA.*(2009).Heterodimericgeranyl(geranyl)diphosphatesynthasefromhop(Humuluslupulus)andtheevolutionofmonoterpenebiosynthesis.Proc.Natl.Acad.Sci.USA.106,9914-9919.
42.Wang,G.#,Tian,L.#,Aziz,N.,Broun,P.,Dai,X.,He,J.,King,A.,Zhao,PX.,andDixon,RA.*(2008).Terpenebiosynthesisinglandulartrichomesofhop.PlantPhysiol148,1254-1266.
43.Wang,G.,andPichersky,E.*(2007).NicotinamidaseparticipatesinthesalvagepathwayofNADbiosynthesisinArabidopsis.PlantJ49,1020-1029.
44.Wang,G.,andChen,X.*(2007).Detoxificationofsoilphenolicpollutantsbyplantsecretoryenzyme.InMethodsinBiotechnologyVol.23:Phytoremediation:MethodsandReviews,(Neil,W.ed.),page49-57.HumanaPress.
45.Iijima,Y.,Wang,G.,Fridman,E.,andPichersky,E.*(2006).Analysisoftheenzymaticformationofcitralintheglandsofsweetbasil.Arch.Biochem.Biophys.448,141-149.
46.Yang.Y.,Varbanova,M.,Ross,J.,Wang,G.,Cortes,D.,Fridman,E.,Shulaev,V.,Noel,J.P.,Pichersky,E.*(2005).Methylationanddemethylationofplantsignalmolecules.InRecentAdvancesinPhytochemistry,Vol.40.page253-270.Oxford:ElsevierScience.
47.Wang,G.,Li,Q.,Luo,B.,andChen,X.*(2004).Explantaphytoremediationoftrichlorophenolandphenolicallelochemicalsviaanengineeredsecretorylaccase.NatBiotechnol22,893-897.
48.Wang,G.,andChen,X.*(2003).Laccase:properties,catalyticmechanismandapplicability.ChineseBulletinofBotany20,469-475.
49.Luo,P.,Wang,Y,Wang,G.,Essenberg,M.,andChen,X.*(2001).Molecularcloningandfunctionalidentificationof(+)-delta-cadinene-8-hydroxylase,acytochromeP450mono-oxygenase(CYP706B1)ofcottonsesquiterpenebiosynthesis.PlantJ28,95-104.
50.Luo,P.,Wang,G.,andChen,X.*(2001).IsolationandexpressionanalysisoftwocDNAencodingC4HhomologuesfromGossypiumarboretum.ActaBotanicaSinica43,77-81.
中文论文：
张凤霞王国栋*(2019).现代代谢组学平台建设及相关技术应用.遗传41,883-892.
李好勋王国栋*(2015).植物腺毛次生代谢产物生物合成的研究进展.中国科学-生命科学45,557-568.
常玉玮*王国栋*(2015).LC-MS在植物代谢组学分析中的应用生命科学27,978-985.
张凤霞王国栋*(2013).植物代谢组学应用研究——现状与展望.中国农业科技导报15,28-32.
王国栋*漆小泉(2012).植物代谢组学(pp.390-403，陈晓亚薛红卫主编《植物生理与分子生物学》)，高等教育出版社.
王国栋*(2011).液相色谱-质谱联用技术(pp.47-62，漆小泉王玉兰陈晓亚主编《植物代谢组学—方法与应用》)，化学工业出版社
王国栋*(2011).LC-MS在植物代谢组学中的应用(pp.204-216，漆小泉王玉兰陈晓亚主编《植物代谢组学—方法与应用》)，化学工业出版社