个人简历

1973年6月出生，教授，博士生导师。1999年毕业于华西医科大学，获理学博士学位。1999年至2004年先后在中山医科大学和美国芝加哥大学从事博士后研究工作。现任干细胞与再生医学国家地方联合工程研究中心主任、干细胞与组织工程教育部重点实验室主任，国家干细胞临床研究专家委员会委员，广东省医学会细胞治疗学分会主任委员。2008年入选教育部“新世纪优秀人才”支持计划，2012年获第十四届“广东青年五四奖章”，2013年获聘广东省高等学校“珠江学者”特聘教授，2014年获国家杰出青年基金资助，2015年获广东省高层次人才特殊支持计划，2016年入选科技部中青年科技创新领军人才，2019年获得第十五届广东省丁颖科技奖

研究领域

""长期从事干细胞多能性与组织器官再生研究，在干细胞治疗的基础研究与临床转化方面取得突出成绩""""

近期论文

Wang J#, Lu Q#, Cai J#, Wang Y, Lai X, Qiu Y, Huang Y, Ke Q, Zhang Y, Guan Y, Wu H, Wang Y, Liu X, Shi Y, Zhang K, Wang M*, Peng Xiang A*. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop. Nat Commun. 2019 Nov 6;10(1):5043. (IF:12.121)\r
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Zhou Y#, Sharma J#, Ke Q#, Landman R#, Yuan J, Chen H, Hayden DS, Fisher JW 3rd, Jiang M, Menegas W, Aida T, Yan T, Zou Y, Xu D, Parmar S, Hyman JB, Fanucci-Kiss A, Meisner O, Wang D, Huang Y, Li Y, Bai Y, Ji W, Lai X, Li W, Huang L, Lu Z, Wang L, Anteraper SA, Sur M, Zhou H, Xiang AP*, Desimone R*, Feng G*, Yang S*. Atypical behaviour and connectivity in SHANK3-mutant macaques. Nature. 2019 Jun;570(7761):326-331. (IF:4778)\r
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Zhang Y#, Wang J#, Huang W#, Cai J, Ba J, Wang Y, Ke Q, Huang Y, Liu X, Qiu Y, Sui X, Shi Y, Wang T, Shen H, Guan Y, Zhou Y, Chen Y, Wang M*, Xiang AP*. Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nat Commun. 2018 Sep 6;9(1):361 (IF:12.121)\r
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Li W#, Huang L#, Zeng J#, Lin W, Li K, Sun J, Huang W, Chen J, Wang G, Ke Q, Duan J, Lai X, Chen R, Liu M, Liu Y, Wang T, Yang X, Chen Y, Xia H*, Xiang AP*. Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry. 2018 Mar;23(3):499-508. (IF:12.384)\r
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Wang J#, Liu X#, Qiu Y#, Shi Y, Cai J, Wang B, Wei X, Ke Q, Sui X, Wang Y, Huang Y, Li H, Wang T, Lin R, Liu Q, Xiang AP*. Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells. J Hematol Oncol. 2018 Jan 22;11(1):11. (IF:11.059)\r
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Lin BL, Chen JF, Qiu WH, Wang KW, Xie DY, Chen XY, Liu QL, Peng L, Li JG, Mei YY, Weng WZ, Peng YW, Cao HJ, Xie JQ, Xie SB, Xiang AP*, Gao ZL*. Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells for Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Randomized Controlled Trial. Hepatology. 2017 Jul;66(1):209-219. (IF:14.679)\r
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Qin A#, Lai DH#, Liu Q#, Huang W#, Wu YP, Chen X, Yan S, Xia H, Hide G, Lun ZR*, Ayala FJ*, Xiang AP*. Guanylate-binding Protein 1 (GBP1) Contributes to the Immunity of Human Mesenchymal Stromal Cells against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1365-1370. (IF:9.412)\r
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Ke Q#, Li W#, Lai X#, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016 Sep;26(9):1048-1061. (IF:20.507)\r
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Jiang MH#, Li G#, Liu J#, Liu L, Wu B, Huang W, He W, Deng C, Wang D, Li C, Lahn BT, Shi C*, Xiang AP*. Nestin+ kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury. Biomaterials. 2015 May;50: 56-66. (IF:10.317) \r
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Peng Y, Chen X, Liu Q, Zhang X, Huang K, Liu L, Li H, Zhou M, Huang F, Fan Z, Sun J, Liu Q, Ke M, Li X, Zhang Q, Xiang AP*. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin Leukemia. 2015 Mar; 29(3):636-646. (IF:8.665)\r
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Li WQ, Huang LH, Lin WY, Ke Q, Chen R, Lai XQ, Wang XY, Zhang JF, Jiang MH, Huang WJ, Wang T, Yang XS, Chen Y, Song W*, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015 Jan;39:75-84. (IF:10.317)\r
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Jiang MH, Cai B, Tuo Y, Wang J, Zang ZJ, Tu X, Gao Y, Su Z, Li W, Li G, Zhang M, Jiao J, Wan Z, Deng C, Lahn BT, Xiang AP*. Characterization of nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. Cell Res. 2014 Dec;24(12):1466-1485. (IF:20.507)\r
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Chen F, Cai B, Gao Y, Yuan XF, Cheng FY, Wang T, Jiang MH, Zhou YJ, Lahn BT, Li WQ, Xiang AP*. Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells. Biomaterials. 2013 Feb;34(6): 1701-1711. (IF:10.317)\r
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Cheng F, Ke Q, Chen F, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP*. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr;33(11):3195-204. (IF:10.317)\r
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Xu CX, Chen XF, Su PQ, Meng YC, Yu WH, Xiang AP*, Wang YJ*. Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering. Biomaterials. 2011 Feb;32(4):1051-8. (IF:10.317)