个人简历

教育经历 2006年9月至2009年6月 博士 中国科学院广州生物医药与健康研究院 2007年8月至2007年10月 MERIT Student 香港中文大学 2002年9月至2005年6月 硕士 中山大学 1998年9月至2002年6月 学士 内蒙古大学 工作经历 2017年9月 至今 教授 中山大学药学院 2014年9月 至 2017年8月 助理科学家 美国加利福尼亚大学戴维斯分校 2010年5月 至 2014年8月 博士后 美国加利福尼亚大学戴维斯分校 2009年7月 至 2009年12月 助理研究员 中国科学院广州生物医药与健康研究院 2005年7月 至 2006年8月 研究助理 中国科学院广州生物医药与健康研究院

研究领域

""主要科研领域与方向: 采用高通量药物筛选平台，生物信息学、基因转录组学、表观遗传组学、CRISPR等技术手段，以细胞、动物及病人样本为材料，开展以表观遗传因子和核受体为靶标的癌症靶向治疗及转化医学研究。1）核受体及表观遗传因子在癌症中的作用机制及细胞信号转导调控；2）以核受体和表观遗传因子为靶点的抗肿瘤药物研究；3）针对耐药性肿瘤的协同药物治疗研究，4）核受体及表观遗传因子对能量代谢的重编程。""""

近期论文

Junjian Wang, June X. Zou, Xiaoqian Xue, Demin Cai1, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C. Yang, Maggie C. Louie, Alexander D. Borowsky, Allen C. Gao, Christopher P. Evans, Kit S. Lam, Jianzhen Xu, Hsing-Jien Kung, Ronald M. Evans, Yong Xu, and Hong-Wu Chen. 2016 ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature Medicine. 22(5):488-96 doi:10.1038/nm.4070. (This paper is highlighted in NATURE, 532, 9, 2016 and NATURE REVIEWS UROLOGY, 13, 237, 2016)\r
Junjian Wang, Haibin Wang, Lingyu Wang, Demin Cai, Zhijian Duan, Yanhong Zhang, Peng Chen, June X. Zou, Jianzhen Xu, Xinbin Chen, Hsing-Jien Kung, Hong-Wu Chen. 2016 Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death&Differentiation. doi: 10.1038/cdd.2016.92.\r
Junjian Wang, Zhijian Duan, Zoann Nugent, June X. Zou, Alexander D. Borowsky, Yanhong Zhang, Clifford G. Tepper, Jian Jian Li, Oliver Fienh, Jianzhen Xu, Leigh Murphy, Hsing-Jien Kung and Hong-Wu Chen. 2016 Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Letters. 378(2):69-79. doi: 10.1016/j.canlet.2016.05.004.\r
Jing Lu, Jingyan Li, Yuehuai Hu, Dayue Darrel Duan, Zhen Guo, Duanping Sun, Panxia Wang, Kaiteng Guo, Si Gao, Jianmin Jiang, Junjian Wang*, Peiqing Liu*, 2018, Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation, Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2018.10.008\r
Jing Yuan, Huiqi Hong, Yuhong Zhang, Jing Lu, Youhui Yu, Xueying Bi, Junjian Wang*, Jiantao Ye*, 2019, Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy through inhibiting JAK2/STAT3 signaling pathway. Cell Biology International, Accepted.\r
Yan Zhang, Xishan Wu, Xiaoqian Xue, Chenchang Li, Junjian Wang, Rui Wang, cheng Zhang, Chao Wang, Yudan Shi, Lingjiao Zou, Qiu Li, Zenghong Huang, Xiaojuan Hao, Kerry M. Loomes, Donghai Wu, Hongwu Chen, Jinxin Xu, and Yong Xu, 2019，Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer (CRPC). J Med Chem. 2019 Apr 9. doi: 10.1021/acs.jmedchem.9b00327.\r
Junjian Wang, June X. Zou, Hong Wang, Zhijian Duan, Haibin Wang, Peng Chen, Peiqing Liu, Jianzhen Xu, Hong-Wu Chen, 2019, Histone methyltransferase NSD2 mediates survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling, Acta Pharmacol Sin. 2019 Jan 22. doi: 10.1038/s41401-018-0199-z.\r
Zhang M, Zhang Y, Song M, Xue X, Wang J, Wang C, Zhang C, Li C, Xiang Q, Zou L, Wu X, Wu C, Dong B, Xue W, Zhou Y, Chen H, Wu D, Ding K, Xu Y. 2018 Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). J Med Chem; 61(7):3037-3058. doi: 10.1021/acs.jmedchem.8b00103.\r
Yuehuai Hu, Zhen Guo, Jing Lu*, Panxia Wang, Shuya Sun, Yiqiang Zhang, Jingyan Li, Qiyao Zheng, Kaiteng Guo, Junjian Wang, Jianmin Jiang*, Peiqing Liu*, 2018 sFRP1 has a biphasic effect on doxorubicin-induced cardiotoxicity in a cellular location-dependent manner in NRCMs and Rats, Archives of Toxicology, https://doi.org/10.1007/s00204-018-2342-5.\r
Xue X, Zhang Y, Wang C, Zhang M, Xiang Q, Wang J, Wang A, Li C, Zhang C, Zou L, Wang R, Wu S, Lu Y, Chen H, Ding K, Li G, Xu Y. 2018 Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur J Med Chem. 2018 May 25;152:542-559. doi: 10.1016/j.ejmech.2018.04.034.\r
Guo Z, Lu J, Li J, Wang P, Li Z, Zhong Y, Guo K, Wang J, Ye J, Liu P. 2018 JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expression. Mol Cell Endocrinol. 2018 May 10. pii: S0303-7207(18)30157-6. doi: 10.1016/j.mce.2018.05.009.\r
Peng Chen, Haibin Wang, Fan Yang, Lujue Dong, Wei He, Hongwu Chen, Junjian Wang*, 2017 Curcumin promotes osteosarcoma cell death by activating miR-125a suppression of ERRα signal pathway. Journal of Cellular Biochemistry. doi: 10.1002/jcb.25612.\r
Ling-Yu Wang, Chiu-Lien Hung, Yun-Ru Chen, Joy C Yang, Junjian Wang, Mel Campbell, Yoshihiro Izumiya, Hong-Wu Chen, Wen-Ching Wang, David K Ann, Hsing-Jien Kung,, 2016 KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Report. 16(11):3016-3027. doi: 10.1016/j.celrep.2016.08.018.\r
Cai D, Wang J, Jia Y, Liu H, Yuan M, Dong H, Zhao R. 2016 Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms. Biochim Biophys Acta- Molecular and Cell Biology of Lipids. 1861(1):41-50.\r