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王亮春
2023-05-18 15:24
  • 王亮春
  • 王亮春 - 研究员 博导-中山大学-孙逸仙纪念医院-个人资料

近期热点

资料介绍

个人简历


教育经历: 2003/7-2008/10,美国明尼苏达大学, 博士后 2000/9 - 2003/7,北京大学,皮肤病学, 博士 1997/9 - 2000/7,山东省医学科学院,皮肤病学,硕士 1992/9 - 1997/7,山东大学,医学,学士 工作经历: 2016/1 - 至今,中山大学,孙逸仙纪念医院,副主任医师 2015/1 - 至今,中山大学,孙逸仙纪念医院,研究员 2008/10 - 2014/12,中山大学,孙逸仙纪念医院,副研究员

研究领域


(1) 伴发Castleman瘤的副肿瘤性天疱疮皮肤损伤发病机制研究:该病是一种以体液免疫为主的自身免疫性大疱性皮肤病,以伴发隐匿的良/恶性肿瘤和反复发作的皮肤黏膜损害为特点。 (2) 经皮肤免疫过程中抗原递呈细胞和效应性CD8 T细胞的特点:通过皮肤划痕、皮下/皮内注射等方法,机体能够获得对水痘,乙肝等病原体的免疫力。我们研究发现,真皮中Langerin+细胞是经皮肤免疫的主要抗原递呈细胞;利用灭活霍乱毒素作为免疫佐剂,改进疫苗接种方案,能显著提高效应性CD8 T细胞的数量和功能,获得更强免疫力。(3) 红斑狼疮、银屑病皮肤损伤发生机制研究: 系统性红斑狼疮(SLE)是一种以体液免疫为主的自身免疫性疾病,全身组织器官均可受累。

近期论文


(1) Liangchun Wang(#),Dingfang Bu,Yong Yang,Xixue Chen,Xuejun Zhu,Castleman's tumours and production of autoantibody in paraneoplastic pemphigus,Lancet,2004,363(9408):525-531。(SCI, 44) (2) Liangchun Wang(#) ,Stephen C. Jameson,Kristin A.Hogquist ,Epidermal Langerhans cells are not required for UV-induced immunosuppression,The Journal of Immunology,2009,183(9):5548-5553。(SCI, 4.98) (3) Liangchun Wang(#),Laura S. Bursch,Adrien Kissenpfennig,Bernard Malissen,Stephen C.Jameson,Kristin A.Hogquist(*),Langerin expressing cells promote skin immune responses under defined conditions,The Journal of Immunology,2008,180(7):4722-4727。(SCI, 4.98) (4) Irlanda Olvera-Gomez,Sara E.Hamilton,Zhengguo Xiao,Carla P.Guimaraes,Hidde L.Ploegh,Kristin A.Hogquist,Liangchun Wang(*),Stephen C.Jameson(*),Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination.,Proceedings of the National Academy of Sciences of the United States of America,2012,109(6):2072-2077。(SCI, 9.42) (5) Shi, Zhen-Rui,Tan, Guo-Zhen,Meng, Zhen,Yu, Min,Li, Kai-Wen,Yin, Jing,Wei, Kai-Hua,Luo, Yi-Jin,Jia, Shu-Qing,Zhang, Shu-Juan,Wu, Jian,Mi, Xiang-Bin,Wang, Liangchun(*),A crucial role of anti-RPLP0 and anti-galectin-3 antibodies in the development of skin lesions in systemic lupus erythematosus.,Arthritis Rheumatol,2015,67(1):193-203。(SCI,8.95) (6) Luo Yin-jin,Tan Guo-zhen,Yu Min,Li Kai-wen,Liu Yue-yang,Guo Qing,Zeng Fan-qin,Wang Liangchun(*),Correlation of cutaneous immunoreactants in lesional skin with the serological disorders and disease activity of systemic lupus erythematosus,PLos One,2013,8(8)。(SCI, 3.05) (7) Yu Min,Kai-wen Li,Tan-guo Zhen,Yi-jin Luo,De-qing Xu,Liangchun Wang(*),The gender disparity of immunoreactants in lesional skin of lupus erythematosus patients,Clinical and Experimental Rheumatology,2012,30(1):103-105。(SCI, 2.49) (8) Tan, G,Zhu, N,Shi, Z,Meng, Z,Yu, M,Li, K,Yin, J,Wei, K,Mi, X,Wang, L(*),Anti-high mobility group box 1 (anti-HMGB1) antibodies are not related to the occurrence of cutaneous lesions in systemic lupus erythematosus.,Scandinavian Journal of Rheumatology,2015,44(2):150-156。(SCI, 2.30) (9) Shi, Z-R,Cao, C-X,Tan, G-Z,Wang, L(*),The association of serum anti-ribosomal P antibody with clinical and serological disorders in systemic lupus erythematosus: a systematic review and meta-analysis.,Lupus,2015,24(6):588-596。(SCI, 2.11) (10) Meng Zhen,Shi Zhen-rui,Tan Guo-zen,Yin Jing,Wu Jian,Mi Xiangbin,Wang liangchun(*),The association of anti-annexin1 antibodies with the occurence of skin lesions in systemic lupus erythematosus,Lupus,2014,23(2):183-187。(SCI, 2.11) (11) Bursch LS, Wang L, Igyarto B, Kissenpfennig A, Malissen B, Kaplan DH, Hogquist KA. Identification of a novel population of Langerin+ dendritic cells. J Exp Med. 2007 Dec 24;204(13):3147-56. (SCI, 11.24) (12) Mayerova D, Wang L, Bursch LS, Hogquist KA. Conditioning of Langerhans cells induced by a primary CD8 T cell response to self-antigen in vivo. J Immunol. 2006 Apr 15;176(8):4658-65. (SCI, 4.98)

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