个人简历

细菌耐药问题一直是困扰医院临床的一大难题，“超级细菌”的不断出现更是引起公众的极大恐慌，成为全球普遍关注的公共安全问题。2014年，世界卫生组织(WHO)发布全球细菌耐药监测报告显示：2013年全球直接死于耐药细菌感染的人数超过100万人，并预测照此趋势到2050年死亡人数将达1000万人/年，超过癌症死亡人数。鉴于细菌耐药问题的严重性，2015年-2016年美英和我国等多国政府相继发布《遏制细菌耐药国家行动计划》，2016年9月二十国集团领导人杭州峰会和联合国大会专门就细菌耐药问题发布联合公报和举行高级别会议，旨在透过全球的共同努力有效解决细菌耐药问题。

研究领域

1.临床病原细菌对β-内酰胺类药物、多粘菌素类药物和替加环素耐药机制研究 2.结核分枝杆菌耐药机制研究 3.耐药基因的分子生物学检测方法建立 4.细菌耐药阻断剂和新型抗生素复方制剂研发

近期论文

1.Lan-Lan Zhong，Nicole Stoesser，Yohei Doi，Cong Shen，Xi Huang，Guo-Bao Tian*（通讯作者），Carriageof β-lactamase-producing Enterobacteriaceae by Chinese travellers，Lancet Infectious Diseases，2017.2.1，17.影响因子22.433 2.Yang Wang*, Guo-Bao Tian*（共同第一作者）, Rong Zhang, Yingbo Shen, Jonathan M. Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R. Walsh, Jianzhong Shen.Clinical associations and molecular epidemiology of mcr-1-positive Escherichia coli in patients and as normal human flora from China: an epidemiology and clinical study. Lancet Infectious Diseases.accepted. 影响因子22.433 3.Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong She, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian*（通讯作者）. Co-production of MCR-1 and NDM-1 by colistin-resistant Escherichia coli isolated from a healthy individual. Antimicrobial Agents and Chemotherapy. 2016 Nov 7. pii: AAC.01962-16. 影响因子4.451. 4.Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB（通讯作者）. Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human. Emerg Infect Dis. 2016 Sep 15;22(9). doi: 10.3201/eid2209.160464. 影响因子6.994. 5.Zeng KJ, Doi Y, Patil S, Huang X, Tian GB（通讯作者）. Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrob Agents Chemother. 2016 May 23;60(6):3862-3. doi: 10.1128/AAC.00345-16. 影响因子4.451. 6.Tian GB（第一作者）, Jiang YQ, Huang YM, Qin Y, Feng LQ, Zhang XF, Li HY, Zhong LL, Zeng KJ, Patil S, Xing Y, Huang X. Characterization of CTX-M-140, a Variant of CTX-M-14 Extended-Spectrum β-Lactamase (ESBL) with Decreased Cephalosporin Hydrolytic Activity, from Cephalosporin-Resistant Proteus mirabilis. Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00822-16. 影响因子4.451. 7.Huang YM, Zhong LL, Zhang XF, Hu HT, Li YQ, Yang XR, Feng LQ, Huang X, Tian GB（通讯作者）. NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter baumannii Identified from a Single Patient in China. Antimicrob Agents Chemother. 2015 Aug;59(8):5073-7. doi: 10.1128/AAC.04682-14. 8.Guo-Bao Tian, Ying-Min Huang, Zhi-Li Fang, Yun Qing, Xue-Fei Zhang, Xi Huang. CTX-M-137, a Hybrid of CTX-M-14-Like and CTX-M-15-Like β-Lactamases Identified in anEscherichia coli Clinical Isolate. J Antimicrob Chemother. 2014;69(8):2081-5. 9.Qing Y, Cao KY, Fang ZL, Huang YM, Zhang XF, Tian GB（共同通讯作者）, Huang X. Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime-Resistant Pseudomonas aeruginosa Clinical Isolates in China. J Med Microbiol. 2014 Jan 7. doi: 10.1099/jmm.0.069427-0.[Epub ahead of print]. 10.Fang ZL, Zhang LY, Huang YM, Qing Y, Cao KY, Tian GB（共同通讯作者）, Huang X. OprD mutations and inactivation in imipenem-resistantPseudomonas aeruginosa isolates from China. Infect Genet Evol. 2014; 21:124-8. 11.Guo-Bao Tian, Hong-Ning Wang, An-Yun Zhang, Yi Zhang, Wen-Qiao Fan, Chang-Wen Xu, Bo Zeng, Zhong-Bin Guan, Li-Kou Zou. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. Journal of Medical Microbiology (ISSN: 0022-2615). 2012; 61(Pt 2):233-8. 12.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong-Ning Wang, Yohei Doi. Identification of Diverse OXA-40-Group Carbapenemases Including a Novel Variant, OXA-160, from Acinetobacter baumannii in Pennsylvania. Antimicrob Agents Chemother.2010; 55:429-32. 13.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. PME-1, an Extended-Spectrum β-lactamase Identified inPseudomonas aeruginosa. Antimicrob Agents Chemother. 2011; 55: 2710-2713. 14.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Yohei Doi. Sequence Type ST405 Escherichia coli Isolate Producing QepA1, CTX-M-15, and RmtB from Detroit, Michigan. Antimicrob Agents Chemother. 2011; 55: 3966-3967. 15.Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. Extended-Spectrum AmpC in Acinetobacter baumannii ADC-56 Confers Resistance to cefepime. Antimicrob Agents Chemother. 2011; 55: 4922-4925. 16.Guo-Bao Tian, Wang Hong-ning, Li-Kou Zou, etc. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. J Med Microbiol. 2012 61(2):233-8. 17.Guo-Bao Tian, Jemelyn Garcia, Jennifer M. Adams-Haduch, Jennifer P. Evangelista, Raul V. Destura, Hong-Ning Wang, Yohei Doi. CTX-M as the predominant extended-spectrum b-Lactamase among Enterobacteriaceae in Manila, Philippines. J Antimicrob Chemother. 2010; 65: 584-6. 18.Guo-Bao Tian, Jennifer M. Adams-Haduch, Zubair A. Qureshi, Hong-Ning Wang, Yohei Doi. CTX-M-35 Extended-Spectrum b-Lactamase Conferring Ceftazidime Resistance in Citrobacter koserii. International Journal of Antimicrobial Agents. 2010; 35: 412-3. 19.Guo-Bao Tian, Wang Hong-ning, Li-Kou Zou, etc. Detection of CTX-M-15, CTX-M-22, and SHV-2 Extended-Spectrum bata-Lactamases (ESBLs) inEscherichia coli Fecal-Sample Isolates from Pig Farms in China. Foodborne Pathogens and Disease. 2009; 6:297-304.