个人简历

中山大学干细胞与组织工程教育部重点实验室教授、博士生导师。广东省医学会细胞治疗学分会委员兼秘书。主要研究方向为多能干细胞向神经嵴分化及其转化应用研究，在SCI杂志（Mol Psychiatry, Cell Res, Biomaterials, Theranostics, Stem Cells等）共发表论文30篇，其中通讯作者或第一作者16篇，影响因子5分以上论文7篇，10分以上4篇。主持国家自然科学基金项目3项，广东省重点领域研发计划、广东省科技厅前沿与关键技术创新专项、广州市健康医疗与协同创新重大专项项目各1项；作为研究骨干参与国家重点研发计划、国家重大科学研究计划、国家自然科学基金联合基金、广东省自然科学基金团队（核心成员）等项目近二十项，研究经费超过1500万元。曾获“中华医学科技奖青年科技奖”（排名第二），申请专利4项，获得授权专利1项。2014年广州市“珠江科技新星”等人才培养计划

研究领域

""主要研究方向为多能干细胞向神经嵴分化及其转化应用研究""""

近期论文

Wang H#, Li D#, Zhai Z#, Zhang X, Huang W, Chen X, Huang L, Liu H, Sun J, Zou Z, Fan Y, Ke Q, Lai X, Wang T, Li X, Shen H, Xiang AP*, Li WQ*. Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells. Theranostics. 2019; 9(6):1683-1697. doi:10.7150/thno.30487. (共同通讯作者)\r
\r
Xiang Q#, Liao Y#, Chao H#, Huang W, Liu J, Chen H, Hong D, Zou Z, Xiang AP, Li WQ*. ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model. Stem Cell Res Ther. 2018 Feb 26;9(1):51. (独立通讯作者)\r
\r
Shi L#, Huang L#, He R#, Huang W, Wang H, Lai X, Zou Z, Sun J, Ke Q, Zheng M, Lu X, Pei Z, Su H, Xiang AP, Li WQ*, Yao X. Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs. Stem Cell Reports. 2018 Jan 9; 10(1):1-14. （共同通讯作者）\r
\r
Ke Q#, Li L#, Yao X#, Lai X, Cai B, Chen H, Chen R, Zhai Z, Huang L, Li K, Hu A, Mao FF, Xiang AP, Tao L*, Li WQ*. Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Sci Rep. 2017 Mar 28;7(1):458. （共同通讯作者）\r
\r
Li WQ#, Huang L#, Zeng J#, Lin W, Li K, Sun J, Huang W, Chen J, Wang G, Ke Q, Duan J, Lai X, Chen R, Liu M, Liu Y, Wang T, Yang X, Chen Y, Xia H*, Xiang AP*. Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry. 2018 Mar;23(3):499-508. （共同第一作者）\r
\r
Ke Q#, Li WQ#, Lai X#, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016 Sep;26(9):1048-61. （共同第一作者）\r
\r
Hu X#, Xie P#, Li WQ#, Li Z, Shan H*. Direct induction of hepatocyte-like cells from immortalized human bone marrow mesenchymal stem cells by overexpression of HNF4α. Biochem Biophys Res Commun. 2016 Sep 16;478(2):791-7. （共同第一作者）\r
\r
Yan S#, Li P#, Wang Y#, Yu W, Qin A, Liu M, Xiang AP, Zhang W*, Li WQ*. Nestin regulates neural stem cell migration via controlling the cell contractility. Int J Biochem Cell Biol. 2016 Sep;78:349-60. （共同通讯作者）\r
\r
Li WQ#, Huang LH#, Lin WY#, Ke Q, Chen R, Lai XQ, Wang XY, Zhang JF, Jiang MH, Huang WJ, Wang T, Yang XS, Chen Y, Song W, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials, 2015 Jan;39:75-84. （共同第一作者）\r
\r
Liu J#, Li WQ#, Wang Y, Fan W, Li P, Lin W, Yang D, Fang R, Feng M, Hu C, Du Z, Wu G*, Xiang AP*. Islet-1 overexpression in human mesenchymal stem cells promotes vascularization through monocyte chemoattractant protein-3. Stem Cells. 2014 Jul;32(7):1843-54.（共同第一作者）\r
\r
Li WQ*, Xiang AP*. Safeguarding clinical translation of pluripotent stem cells with suicide genes. Organogenesis. 2013 Jan-Mar;9(1):34-9. （第一作者、共同通讯作者）\r
\r
Cheng F#, Ke Q#, Chen F#, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li WQ*, Xiang AP*. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr;33(11):3195-204. （共同通讯作者）\r
\r
Yao XL#*, Liu Q#, Ye CH, Li ZP, Lu XL, Li PL, Li XB, Li WQ*. Neuronal differentiation potential of mouse induced pluripotent stem cells. Neuroreport. 2011 Oct 5; 22(14):689-95. （共同通讯作者）\r
\r
Qin J#, Li WQ#, Zhang L, Chen F, Liang WH, Mao FF, Zhang XM, Lahn BT, Yu WH*, Xiang AP*. A stem cell-based tool for small molecule screening in adipogenesis. PLoS One. 2010 Sep27; 5 (9): e13014. （共同第一作者）\r
\r
Li WQ#, Liu C#, Qin J, Zhang L, Chen R, Chen J, Yu X, Wu G, Lahn BT, Fu Y, Xiang AP. Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors. Cell transplant. 2010; 19(9):1181-93. （共同第一作者）\r
\r
Li WQ#, Wang D#, Qin J, Liu C, Zhang Q, Zhang X, Yu X, Lahn BT, Mao FF, Xiang AP. Generation of functional hepatocytes from mouse induced pluripotent stem cells. J Cell Physiol. 2010 Mar; 222(3): 492-501. （共同第一作者）