个人简历

2018-至今，获聘“青年珠江学者” 2017-至今，中山大学生命科学学院，教授 2013-2017，芝加哥大学，生物分子动态研究所，博士后（合作导师：何川） 2010-2013，中科院遗传发育所，分子系统中心，助理研究员 2005-2010，中科院遗传发育所，生物信息学，博士 （导师：王秀杰） 2001-2005，东南大学，生物医学工程，本科

研究领域

1. 核酸修饰如DNA、RNA甲基化的测序及功能研究 2. 新测序方法及生物信息算法的开发 3. 干细胞重编程中的表观遗传调控机理 4. 表观遗传对基因表达的调控

近期论文

Wang X#, Li Y#, Chen W, Shi H, Eren AM, Morozov A, He C, Luo GZ*, Pan T*. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Research. (In press) Chen Z, Qi M, Shen B, Luo G, Wu Y, Li J, Lu Z, Zheng Z, Dai Q, Wang H. Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs. Nucleic Acids Research. (In press) Luo GZ*#, Hao Z#, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP and He C*. N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA. Genome Biology. 19:200 (2018) Yue Y, Liu J, Cui X, Cao J, Luo G, Zhang Z, Cheng T, Gao M, Shu X, Ma H, Wang F, Wang X, Shen B, Wang Y, Feng X, He C, Liu J. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discovery. 4:10 (2018) Zhu S, Beaulaurier J, Deikus G, Wu TP, Strahl M, Hao Z, Luo G, Gregory JA, Chess A, He C, Xiao A, Sebra R, Schadt EE, Fang G. Mapping and characterizing N6-methyladenine in eukaryotic genomes using single-molecule real-time sequencing. Genome Research. 28(7):1067-1078 (2018) Luo GZ & He C. DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander? Nature Structural & Molecular Biology. 24(6):503-506 (2017) Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang X, Guerrero L, Xie P, He E, Shen B, He C. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. Elife. pii: e31311 (2017) Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Research. 27(9):1115-1127 (2017) Liu J#, Zhu Y#, Luo GZ#, Wang X#, Yue Y, Wang X, Zong X, Chen K, Yin H, Fu Y, Han D, Wang Y, Chen D, He C. Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig. Nature Communications.7:13052 (2016) Luo GZ#, Wang F#, Weng X, Chen K, Hao Z, Yu M, Deng X, Liu J, He C. Characterization of eukaryotic DNA N6-methyladenine by a highly sensitive restriction enzyme-assisted sequencing. Nature Communications. 7:11301 (2016) Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C. ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. 167(3): 816-828 (2016) Feng G, Tong M, Xia B, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. EMBO Reports. 17(9):1304-13 (2016) Luo GZ, Blanco MA, Greer EL, He C, Shi Y. DNA N6-methyladenine: a new epigenetic mark in eukaryotes? Nature Reviews Molecular Cell Biology. 16(12):705-10 (2015) Fu Y#, Luo GZ#, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Doré LC, Weng X, Ji Q, Mets L, He C. N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas. Cell. 161(4):879-92 (2015) (# co-first author). Chen K, Luo GZ, He C. High-Resolution Mapping of N⁶-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy. Methods Enzymol. 560:161-85 (2015) Shuai L, Wang Y, Dong M, Wang X, Sang L, Wang M, Wan H, Luo G, Gu T, Yuan Y, Feng C, Teng F, Li W, Liu X, Li T, Wang L, Wang XJ, Zhao XY, Zhou Q. Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro. J Mol Cell Biol. 7(4):326-37 (2015) Deng X, Chen K, Luo GZ, Weng X, Ji Q, Zhou T, He C. Widespread occurrence of N6-methyladenosine in bacterial mRNA. Nucleic Acids Research. 43(13):6557-67 (2015) Chen K, Lu Z, Wang X, Fu Y, Luo GZ, Liu N, Han D, Dominissini D, Dai Q, Pan T and He C. High-Resolution N6-Methyladenosine (m6A) Map Using Photo-Crosslinking-Assisted m6A Sequencing. Angew Chem Int Ed Engl. 54(5):1587-90 (2015)