赖小敏
近期热点
资料介绍
个人简历
1990年微生物学与免疫学硕士毕业,教授。现任中山大学中山医学院微生物学教研室副主任,中国医药生物技术协会实验室生物安全专业委员会委员、中国微生物学会微生物生物安全专业委员会委员、中国畜牧医学会兽医公共卫生学分会实验室生物安全专业委员会委员、中国微生物学会会员、广东省病毒学会理事、美国微生物学会会员。 2000年2月至2003年2月在美国哈佛医学院Beth Israel医学中心病毒致病系结核病研究室从事访问研究期间,从免疫生物学、分子与细胞免疫学等角度研究了结核与艾滋病相关结核的猿猴各种免疫细胞的转归。2003年至2012年参与了中山大学生物安全三级实验室的建设与管理工作。研究领域
目前研究方向为结核分枝杆菌的致病与免疫分子机制、细胞免疫学方法及抗结核菌海洋微生物功能分子开发研究。近期论文
1. Anti-mycobacterial activity of marine Fungus-derived 4-deoxybostrycin and nigrosporin 所有作者:Cong Wang, Juan Wang, Yuhong Huang, Hong Chen, Yan Li, Lili Zhong, Yi Chen, Shengping Chen, Jun Wang, Juling Kang, Yi Peng, Bin Yang, Yongcheng Lin, Zhigang She*, Xiaomin Lai*. 发表杂志:Molecules 2013; 18(2):1728-1740. (IF:2.386) 发表年份:2013 2. Relatively low level of antigen-specific monocytes detected in blood from untreated tuberculosis patients using CD4+ T-cell receptor tetramers 所有作者:Huang Y, Huang Y, Fang Y, Wang J, Li Y, Wang N, Zhang J, Gao M, Huang L, Yang F, Wang C, Lin S, Yao Y, Ren L, Chen Y, Du X, Xie D, Wu R, Zhang K, Jiang L*, Yu X*, Lai X*. 发表杂志:PLoS Pathog 2012; 8(11):e1003036. (IF:9.127) 发表年份:2012 3. Monitoring of peptide-specific and gamma interferon-productive T cells in patients with active and convalescent tuberculosis using an enzyme-linked immunosorbent spot assay 所有作者:Fangfang Yang, Zhiquan Tu, Yimin Fang, Yan Li, Yi Peng, Tao Dong, Cong Wang, Shuxian Lin, Nengyong Zhan, Zhiming Ma, Yongzhong Feng, Shouyong Tan*, Xiaomin Lai*. 发表杂志:Clin Vaccine Immunol 2012; 19(3):401-410. (IF:2.546) 发表年份:2012 4. Interferon-gamma ELISPOT for the screening and diagnosis of latent tuberculosis infection in chinese healthy population 所有作者:Yi Peng, Fangfang Yang, Lin Zhou, Meigui Zhao, Yan Li, Yuhong Huang, Juan Wang, Lirong Huang, Dan Xie,Zhiquan Tu, Weiling Lin, Jinhong Liu*, Qiu Zhong*, Xiaomin Lai*. 发表杂志:Adv Biosci Biotechnol 2012; 3:259-268. 发表年份:2012 5. Use of HLA-DR*08032/E7 and HLA-DR*0818/E7 tetramers in tracking of epitope-specific CD4+ T cells in active and convalescent tuberculosis patients compared with control donors 所有作者:Yan Li, Yan Zhu, Lin Zhou, Yimin Fang, Lirong Huang, Liangliang Ren, Yi Peng, Yifen Li, Fangfang Yang, Dan Xie, Wenzheng Tang, Na Zhang, Qiu Zhong*, Xiaomin Lai*. 发表杂志:Immunobiology 2011; 216(8):947-960. (IF:4.114) 发表年份:2011 6. Antimycobacterial activity of fusaric acid from a mangrove endophyte and its metal complexes 所有作者:Jiahui Pan, Yi Chen, Yuhong Huang, Yiwen Tao, Jun Wang, Yan Li, Yi Peng, Tao Dong, Xiaomin Lai*, Yongcheng Lin*. (带*的为通讯作者) 发表杂志:Arch Pharm Res 2011; 34(7):1177-1181.(IF:1.592) 发表年份:2011 7. Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vγ2Vδ2+ TCR 所有作者:Huiyong Wei, Dan Huang, Xiaomin Lai, Meiling Chen, Weihua Zhong, Richard Wang, Zheng W Chen. 发表杂志:J Immunol 2008; 181 (7): 4798-4806. 发表年份:2008 8. Immune gene networks of mycobacterial vaccine-elicited cellular responses and immunity 所有作者:Dan Huang, Liyou Qiu, Richard Wang, Xiaomin Lai, George Du, Probhat Seghal, Yun Shen, Lingyun Shao, Lisa Halliday, Jeff Fortman, Ling Shen, Norman L Letvin, Zheng W Chen. 发表杂志:J Infect Dis 2007; 195 (1) : 55-69. 发表年份:2007 9. Immune biology of macaque lymphocyte populations during mycobacterial infection 所有作者:Xiaomin Lai, Yun Shen, Dejiang Zhou, Prabhat K. Sehgal, Ling Shen, Meredith Simon, Liyou Qiu, Norman L. Letvin, Zheng W. Chen. 发表杂志:Clin Exp Immunol 2003; 133(2):182–192. 发表年份:2003 10. Adaptive immune response of Vγ2Vδ2+ T cells during mycobacterial infections 所有作者:Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW. 发表杂志:Science 2002; 295(22):2255-2258. 发表年份:2002 11. Inhibition of adaptive Vγ2Vδ2+ T-cell responses during active mycobacterial coinfection of Simian immunodeficiency virus SIVmac-infected Monkeys 所有作者:Dejiang Zhou, Xiaomin Lai, Yun Shen, Prabhat Sehgal, Ling Shen, Meredith Simon, Liyou Qiu, Dan Huang, George Z. Du, Qifan Wang, Norman L. Letvin, Zheng W. Chen. 发表杂志:J Virol 2003; 77(5):2998-3006. 发表年份:2003 12. Induction of an AIDS virus-related tuberculosis-like disease in macaques:a model of simian immunodeficiency virus-mycobacterium coinfection 所有作者:Yun Shen, Dejiang Zhou, Laura Chalifoux, Ling Shen, Meredith Simon, Xuejun Zeng, Xiaomin Lai, Yunyuan Li, Prabhat Sehgal, Norman L. Letvin, Zheng W. Chen. 发表杂志:Infect Immun 2002; 70(2):869-877 发表年份:2002 13. The TCR repertoire of an immunodominant CD8+ T lymphocyte population 所有作者:Zheng W. Chen, Yunyuan Li, Xuejun Zeng, Marcelo J. Kuroda, Jöern E. Schmitz, Yun Shen, Xiaomin Lai, Ling Shen, Norman L. Letvin. 发表杂志:J Immunol 2001; 166(7):4525-4533 发表年份:2001 相关热点
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