个人简历

1982年获中山大学化学学士学位；1988年获美国俄亥俄州迈阿密大学化学硕士学位；1993年获美国布朗大学的生物学博士学位，并获得Barry Rosen 分子生物学优异奖。博士毕业后于1993至1998年在世界著名的生物研究所美国冷泉港实验室做博士后研究员，并获得著名的Damon Runyon-Walter Winchell癌症基金会博士后基金。1998年加入香港科技大学，主持DNA复制与癌症实验室。现任香港科技大学生命科学部/癌症研究中心副主任。

研究领域

DNA复制

近期论文

　1. Huo L., R. Wu, Z. Yu, Y. Zhai, X. Yang, T. Chan, J. Yeung, J. Kan, and *Liang C. (2012) The Rix1 (Ipi1p-2p-3p) Complex Is a Critical Determinant of DNA Replication Licensing Independent of Their Roles in Ribosome Biogenesis. Cell Cycle 11, 1325-1339.　2. Liu, C., Wu, R., Wei, Z., Wang, J., Tye, B., *Liang, C., and *Zhu G. (2012) Structural Insights into the Cdt1-Mediated Mcm2-7 Chromatin Loading. Nucleic Acids Res. 40, 3208-3217 (*co-corresponding authors).　3. Wu, R., Wang, J., and Liang, C. (2012) Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex.J. Cell Sci.125, 209-219.　4. Geng, H., Law, P., Ng, M., Li, T., Liang, L., Ge, T., Wong, K.,Liang, C.,Ma, R., So, W., Chan, J., Ho, Y. (2011) APOE Genotype-Function Relationship: Evidence of 2491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk. PLoS ONE 6, e24669-e24669　5. Zhai, Y., Yung, P., and Liang. C. (2011) Cell cycle control of DNA replication by phosphorylation and dephosphorylation of replication-initiation proteins in budding yeast. Chapter 6 in “Fundamental Aspects of DNA Replication”. InTech Publisher; Ed. J. Kus?ic?-Tis?ma; pp87-106.　6. Lai, F.Q., Wu, R.T. Wang, J.F., Li, C.M., Zou, L., Lu Y.J., and Liang, C. (2011) Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. FEMS Yeast Res. 11, 72-79.　7. Zhang J., Yu, L., Wu., X., Zou., L. Sou, K.K.L, Wei, Z., Cheng X., Zhu, G.*. and Liang C.* (2010) The Interacting Domains of hCdt1 and hMcm6 Involved in the Chromatin Loading of the MCM Complex in Human Cells. CellCycle 9, 4848-4857 (*co-corresponding authors) 8. Ma, L.J., Zhai, Y.L., Feng, D.R., Chan, T.C., Lu, J.L., Fu, X.R., Wang, J.F., Chen, Y.H., Li, J.N., Xu, K. and Liang, C. (2010) Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen in Saccharomyces cerevisiae. Cell Cycle 9, 4399-4410.　9. Zhai, Y.L. Yung, P., Huo L. and Liang C. (2010) Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins. J. Cell Sci. 123, 3933-3943.　10. Cheng, X., Xu, Z., Wang, J.F., Zhai, Y.L, Lu, Y.J, and Liang, C. (2010) ATP-dependent Pre-replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast.. J. Biol. Chem. 285, 29974-29980.　11. Wei, Z., Liu, C.D., Xu, N.N., Wu, X. Zhou, B., Liang, C.*, and Zhu, G.*（2010）Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J. Boil. Chem. 285, 12469-12473 (accelerated publication)(*co-corresponding authors).　12. Wang, J.F., Wu, R.T., Lu, Y.J. and Liang, C. (2010) Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast.Biochem. Biophys. Res. Commun. 395, 336-341.