个人简历

1. 2018-08-至今：中山大学，海洋科学学院，副教授，博士生导师； 2. 2015/08 – 2018-07：中山大学，海洋科学学院，特聘研究员； 3. 2013/06 – 2015/07：中山大学，生命科学学院，博士后（合作导师：林浩然院士）； 4. 2008/09 – 2013/06：中山大学，生命科学学院，海洋生物学专业，博士（硕博连读,导师：何建国教授）； 5. 2004/09 – 2008/06：中南林业科技大学，生命科学学院，生物技术专业，学士。

研究领域

课题组主要以对虾为材料，开展对虾基础免疫学及遗传育种相关研究。具体研究工作为对虾免疫系统的解析；对虾免疫系统与病原（细菌及病毒）之间的相互作用机制研究；对虾经济性状的分子标记开发、遗传育种模型建立、新品种及新品系的选育。在对虾基础免疫学研究方面，课题组在解析对虾Toll和IMD信号通路、对虾核酸诱导免疫激活通路（STING/IRF/Vago/JAK-STAT）调控机制方面以及对虾免疫系统与细菌和白斑综合症病毒互作机制方面取得了一些重要的研究进展

近期论文

RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides. PLoS Pathogens 2018. Haoyang Li, Bin Yin, Sheng Wang, Qihui Fu, Bang Xiao, Kai Lv, Jianguo He*, Chaozheng Li* (* Corresponding author). WSSV–host interaction: Host response and immune evasion (Review). Fish & Shellfish Immunology 2019. Chaozheng Li, Shaoping Weng, Jianguo He* (* Corresponding author). The c-Fos and c-Jun from Litopenaeus vannamei play opposite roles in Vibrio parahaemolyticus and white spot syndrome virus infection. Developmental and Comparative Immunology 2015 52:26–36. Chaozheng Li*, Haoyang Li, Sheng Wang, Xuan Song, Zijian Zhang, Zhe Qian, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He * (* Corresponding author) Shrimp with knockdown of LvSOCS2, a negative feedback loop regulator of JAK/STAT pathway in Litopenaeus vannamei, exhibit enhanced resistance against WSSV. Developmental and Comparative Immunology 2016 65:289-298. Sheng Wang, Xuan Song, Zijian Zhang, Haoyang Li, Kai Lǚ, Bin Yin, Jianguo He*, Chaozheng Li* (* Corresponding author) Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection. Molecular Immunology 2017 88:10-19. Sheng Wang, Mengqiao Li, Bin Yin, Haoyang Li, Bang Xiao, Kai Lǚ, Zhijian Huang, Sedong Li, Jianguo He⁎, Chaozheng Li⁎ (* Corresponding author) Presence of Tube isoforms in Litopenaeus vannamei suggests various regulatory patterns of signal transduction in invertebrate NF-kB pathway. Developmental and Comparative Immunology 2014 42: 174–185. Chaozheng Li, Yixiao Chen, Shaoping Weng, Sedong Li, Hongliang Zuo, Xiaoqiang Yu, Haoyang Li, Jianguo He *, Xiaopeng Xu * (* Corresponding author) Pellino protein from pacific white shrimp Litopenaeus vannamei positively regulates NF-kB activation. Developmental and Comparative Immunology 2014 44(2):341-50. Chaozheng Li, Jiaoting Chai, Haoyang Li, Hongliang Zuo, Sheng Wang, Wei Qiu, Shaoping Weng, Jianguo He*, Xiaopeng Xu* (* Corresponding author) Molecular cloning, expression, promoter analysis and functional characterization of a new Crustin from Litopenaeus vannamei. Fish & Shellfish Immunology 2018. Ming Lia, Chunxia Ma, Haoyang Li, Jinxia Peng, Digang Zeng, Xiaohan Chen∗, Chaozheng Li∗ (* Corresponding author) MKK6 from pacific white shrimp Litopenaeus vannamei is responsive to bacterial and WSSV infection. Molecular Immunology 2016 70: 72–83. Haoyang Li, Sheng Wang, Yonggui Chen, Kai Lǚ, BinYin, Sedong Li, Jianguo He *, Chaozheng Li * (* Corresponding author) MKK4 from Litopenaeus vannamei is a regulator of p38 MAPK kinase and involved in anti-bacterial response. Developmental and Comparative Immunology 2018 78:61-70. Sheng Wang, Bin Yin, Haoyang Li, Bang Xiao, Kai Lǚ, Chiguang Feng, Jianguo He*, Chaozheng Li* (* Corresponding author) Identification, Characterization, and Function Analysis of the Cactus Gene from Litopenaeus vannamei. Plos One 2012 7(11):e49711. Chaozheng Li, Yi-Xiao Chen, Shuang Zhang, Ling Lu, Yi-Hong Chen, Jiaoting Chai, Shaoping Weng, Yong-Gui Chen, Jianguo He*, Xiaopeng Xu* (* Corresponding author) Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei. Fish & Shellfish Immunology 2015. Muting Yan, Chaozheng Li, Ziqi Su, Qianhui Liang, Haoyang Li, Shizhong Liang, Shaoping Weng, Jianguo He, *, Xiaopeng Xu* (* Corresponding author)； Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei. Developmental and Comparative Immunology 2014. Ming Li, Chaozheng Li, Chunxia Ma, Haoyang Li, Hongliang Zuo, Shaoping Weng, Xiaohan Chen, Digang Zeng, Jianguo He∗, Xiaopeng Xu ∗ (* Corresponding author) Identification and functional characterization of the TAB2 gene from Litopenaeus vannamei. Fish & Shellfish Immunology 2015 46(2):206-16. Sheng Wang, Haoyang Li, Zhe Qian, Xuan Song, Zijian Zhang, Hongliang Zuo, Xiaopeng Xu, Shaoping Weng, Jianguo He*, Chaozheng Li* (* Corresponding author) Identification and functional analysis of a TEP gene from a crustacean reveals its transcriptional regulation mediated by NF-κB and JNK pathways and its broad protective roles against multiple pathogens. Developmental and Comparative Immunology 2017 70: 45-58. Chaozheng Li *, Haoyang Li, Bang Xiao, Yonggui Chen, Sheng Wang, Kai Lǚ, Bin Yin, Sedong Li, Jianguo He * (* Corresponding author) Identification and characterization of transforming growth factor β-activated kinase 1 from Litopenaeus vannamei involved in anti-bacterial host defense. Fish & Shellfish Immunology 2016 52: 278-288. Sheng Wang, Haoyang Li, Kai Lǚ, Zhe Qian, Shaoping Weng, Jianguo He *, Chaozheng Li * (* Corresponding author) Identification and characterization of MKK7 as an upstream activator of JNK in Litopenaeus vannamei. Fish & Shellfish Immunology 2016 48: 285-294. Sheng Wang, Zhe Qian, Haoyang Li, Kai Lǚ, Xiaopeng Xu, Shaoping Weng, Jianguo He *, Chaozheng Li * (* Corresponding author) Identifcation of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response. Scientific Reports 2017 7:45821. Haoyang Li, Sheng Wang, Yonggui Chen, Kai Lǚ, BinYin, Sedong Li, Jianguo He * & Chaozheng Li * (* Corresponding author) Cloning, identification and functional analysis of a b-catenin homologue from Pacific white shrimp, Litopenaeus vannamei. Fish & Shellfish Immunology 2016 54:411-8. Shuang Zhang, Lili Shi, Kai Lǚ, Haoyang Li, Sheng Wang, Jianguo He*, Chaozheng Li* (* Corresponding author) Analysis of Litopenaeus vannamei Transcriptome Using the Next-Generation DNA Sequencing Technique. PLoS ONE 2012 7,10: e47442. Chaozheng Li, Shaoping Weng, Yonggui Chen, Xiaoqiang Yu, Ling Lu, Haiqing Zhang, Jianguo He *, Xiaopeng Xu * (* Corresponding author)