个人简历

关新元教授于1993年获得美国亚利桑那大学（University of Arizona）遗传学博士， 在美国密西根大学（University of Michigan）肿瘤学系完成博士后工作，于1993年9月加入美国国家健康研究院（NIH）国家人类基因组研究所（National Human Genome Research Institute），任研究员（Senior Staff)。1994-1999年，任NHGRI显微切割研究小组组长。1999年加入香港大学，任临床肿瘤系副教授、教授

研究领域

""集中于寻找与肝癌、食道癌及鼻咽癌发生相关的基因、肿瘤干细胞和肿瘤微环境""""

近期论文

Ming XY, Fu L, Zhang LY, Qin YR, Cao TT, Chan KW, Ma S, Xie D, Guan XY*. Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma. Nat Commun. 2016 Dec 7;7:13568. doi: 10.1038/ncomms13568.\r
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Liu M, Chen L, Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY*. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 2016 May;63(5):1544-59. doi: 10.1002/hep.28437.\r
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Song Y, Pan G, Chen L, Ma S, Zeng T, Man Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY*. Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.Gastroenterology. 2015 Oct;149(4):1068-81.e5. doi: 10.1053/j.gastro.2015.06.010.\r
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Li Y*, Fu L, Li JB, Qin Y, Zeng TT, Zhou J, Zeng ZL, Chen J, Cao TT, Ban X, Qian C, Cai Z, Xie D, Huang P, Guan XY*. Increased Expression of EIF5A2, via Hypoxia or Gene Amplification, Contributes to Metastasis and Angiogenesis of Esophageal Squamous Cell Carcinoma. Gastroenterology. 2014 Jun;146(7):1701-1713.\r
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Liu L, Dai Y, Chen J, Zeng T, Li Y, Chen L, Zhu Y, Li J, Li Y, Xie D, Yuan YF, Guan XY*. Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling. Hepatology 2014;59(2):531-43.\r
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Chen L, Li Y, Lin CH, Chan TH, Chow RK, Song Y, Liu M, Yuan YF, Fu L, Kong KL, Qi L, Li Y, Zhang N, Tong AH, Kwong DL, Man K, Lo CM, Lok S, Tenen DG*, Guan XY*. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nature Medicine 2013;19(2):209-16.\r
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Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Yuan YF, Guan XY*. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology 2013;144(1):179-191.\r
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Ma S, Bao YJ, Kwan PS, Chan YP, Tong CM, Fu L, Zhang N, Tong AH Qin YR, Tsao SW, Chan KW, Lok S, Guan XY*. Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma. Gastroenterology 2012;143(3):675-86.\r
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Liu M, Chen L, Chan TH, Wang J, LiY, Li Y, Zeng TT, Yuan YF, Guan XY*. Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma. Hepatology 2012;55(6):1754-65.\r
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Chan TH, Chen L, Liu M, Hu L, Zheng BJ, Poon VK, Huang P, Yuan YF, Huang JD, Yang J, Tsao GS, Guan XY*. Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology 2012;55(2):491-505.\r
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Kong KL, Kwong DL, Chan TH, Law SY, Chen L, Li Y, Qin YR, Guan XY*. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut 2012;61(1):33-42.\r
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Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL Guan XY*. Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut 2011;60(12):1635-43.\r
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Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J, Guan XY*. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut 2011;60(4):534-43.\r
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Ma S*, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng I, Man K, Wong N, To KF, Zheng BJ, Lai PB, Lo CM, Chan KW*, Guan XY*. miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010;7(6):694-707.