个人简历

现任中山大学中山医学院副院长、生物化学教研室主任。1997年获中山医科大学生物化学专业博士学位，1999.1-2002.5期间在美国进行博士后研究工作，2004年晋升教授、博士生导师。担任广东省基因操作和生物大分子产物工程技术研究中心主任，海洋微生物功能分子广东省高校重点实验室主任。入选教育部首届新世纪优秀人才计划、广东省高等学校千百十工程国家级培养对象、宝钢优秀教师、广东省特支计划领军人才，享受国务院政府津贴。 当选广东省生物化学和分子生物学学会理事长，中国生物化学和分子生物学学会理事，中国生物化学和分子生物学学会医学分会常务理事，中国生物化学和分子生物学学会脂质与脂蛋白专业委员会委员，中国生物化学和分子生物学学会代谢专业委员会委员。

研究领域

研究方向为肿瘤等病理性血管新生的发生机制和生物治疗，近年来开展的另一研究方向为肿瘤、糖尿病糖脂代谢异常关键分子的作用和调控。

近期论文

1. Qi W, Yang C, Dai Z, Che D, Feng J, Mao Y, Cheng R, Wang Z, He X, Zhou T, Gu X, Yan L*, Yang X*, Ma JX*, Gao G*. High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes. 2014 Nov 3. pii: DB_141111. [Epub ahead of print] (Impact factor 8.5) 2. Li L, Yao YC, Gu XQ, Che D, Ma CQ, Dai ZY, Li C, Zhou T, Cai WB, Yang ZH, Yang X*, Gao GQ*. Plasminogen kringle 5 induces endothelial cell apoptosis by triggering a voltage-dependent anion channel 1 (VDAC1) positive feedback loop. J Biol Chem. 2014 Oct 8. pii: jbc.M114.567792. [Epub ahead of print] (Impact factor 4.6) 3. Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X*, Gao G*. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014 Nov; 148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5. (Impact factor 4.2) 4. Huang L, Zhang T, Li S, Duan J, Ye F, Li H, She Z, Gao G*, Yang X*. Anthraquinone G503 Induces Apoptosis in Gastric Cancer Cells through the Mitochondrial Pathway. PLoS One. 2014 Sep 30; 9(9):e108286. doi: 10.1371/journal.pone.0108286. eCollection 2014. (Impact factor 3.6) 5. Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, Yang X, Gao G*, Yang Z*. Proapoptotic PEDF functional peptides inhibit prostate tumor growth-A mechanistic study. Biochem Pharmacol. 2014 Sep 28. pii: S0006-2952(14)00556-5. doi: 10.1016/j.bcp.2014.09.012. [Epub ahead of print] (Impact factor 4.7) 6. Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X*, Gao GQ*. Pigment Epithelial-derived Factor (PEDF)-triggered Lung Cancer Cell Apoptosis Relies on p53 Protein-driven Fas Ligand (Fas-L) Up-regulation and Fas Protein Cell Surface Translocation. J Biol Chem. 2014 Oct 31; 289(44):30785-99. doi: 10.1074/jbc.M114.590000. Epub 2014 Sep 15. (Impact factor 4.6) 7. Xia Y*, Lin LY, Liu ML, Wang Z, Hong HH, Guo XG, Gao GQ. Selective inhibition of CDK7 ameliorates experimental arthritis in mice. Clin Exp Med. 2014 Aug 23. [Epub ahead of print] (Impact factor 2.3) 8. Zhiyu Dai, Ti zhou, Cen Li, Weiwei Qi, Yuling Mao, Juling Lu, Yachao Yao, Lei Li, Ting Zhang, Honghai Hong, Shuai Li, Weibin Cai, Zhonghan Yang, Jianxing Ma, Xia Yang* and Guoquan Gao*. Intracellular Pigment Epithelium-Derived Factor Contributes to Triglyceride Degradation. Int J Biochem Cell Biol. 2013 Sep; 45(9):2076-86. doi: 10.1016/j.biocel.2013.07.008. Epub 2013 Jul 22. (Impact factor 4.2) 9. Zhiyu Dai, Weiwei Qi, Cen Li, Juling Lu, Yuling Mao,Yachao Yao, Lei Li, Ting Zhang, Honghai Hong, Shuai Li, Ti Zhou, Zhonghan Yang, Xia Yang, Guoquan Gao* and Weibin Cai*. Dual Regulation of Adipose Triglyceride Lipase by Pigment Epithelium-Derived Factor: A Novel Mechanistic Insight into Progressive Obesity. Mol Cell Endocrinol. 2013 Sep 5; 377(1-2):123-34. doi: 10.1016/j.mce.2013.07.001. Epub 2013 Jul 10. (Impact factor 4.1) 10. Yachao Yao, Lei Li, Xuan Huang, Xiaoqiong Gu, Zumin Xu, Yang Zhang, Lijun Huang, Shuai Li, Zhiyu Dai, Cen Li, Ti Zhou, Weibin Cai, ZhonghanYang, Guoquan Gao*, Xia Yang*. SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway. FEBS J. 2013 Jul; 280(14):3244-55. doi: 10.1111/febs.12303. [Epub ahead of print]. (Impact factor 4.25) 11. Rui Cheng, Cen Li, Chaoyang Li, Ling Wei, Lei Li, Yang Zhang, Yachao Yao, Xiaoqiong Gu, Weibin Cai, Zhonghan Yang, Xia Yang*, Guoquan Gao*. Artemisinin derivative inhibits corneal neovascularization via inducing ROS-dependent endothelial cell apoptosis. Invest Ophthalmol Vis Sci. 2013 May 15;54(5):3400-9. doi: 10.1167/iovs.12-11068. (Impact factor 3.5) 12. Weibin Cai, Yang Zhang, Rui Cheng, Zheng Wang, Shuhuan Fang, Zumin Xu, Xia Yang, Zhonghan Yang, Jian-xin Ma, Chunkui Shao*, Guoquan Gao* (Corresponding author). Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1a Pathway. PLoS ONE, December 2012；7(12): e53152. doi:10.1371/journal.pone.0053152. (Impact factor 4.1) 13. Zhiyu Dai, Lei Lu, ZhonghanYang, Yuling Mao, Juling Lu, Cen Li, Weiwei Qi, Yifei Chen, Yachao Yao, Lei Li, Shaobo Chen, Yang Zhang, Weibin Cai, Xia Yang* and Guoquan Gao* (Corresponding author). Kallikrein-binding Protein Inhibits LPS-induced TNF-α by Upregulating SOCS3 Expression. J Cell Biochem. 2013 May;114(5):1020-8. (Impact factor 2.87) 14. Cen Li, Lei Li, Rui Cheng, Zhiyu Dai, Chaoyang Li, Yachao Yao, Ti Zhou, Zhonghan Yang, Guoquan Gao* (Co-corresponding author), Xia Yang*. Acidic/neutral amino acid residues substitution in NH2 terminal of Plasminogen kringle5 exerts enhanced effects on corneal neovascularization. Cornea, 2013 May;32(5):680-8. (Impact factor 1.73) 15. Zhiyu Dai, Yifei Chen, Weiwei Qi, Lijun Huang, Yang Zhang, Ti Zhou, Xia Yang* and Guoquan Gao* (Corresponding author). Codon optimization increases human Kallistatin expression in Escherichia coli. Preparative Biochemistry & Biotechnology, 2013; 43(1):123-36. (Impact factor 0.5) 16. Li L, Yang J, Wang WW, Yao YC, Fang SH, Dai ZY, Hong HH, Yang X, Shuai XT*, Gao GQ* (Corresponding author). Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells. Int J Pharmaceut. 2012 Sep; 438:1-10. (Impact factor 3.5) 17. Jianfang Ma, Chaoyang Li, Chunkui Shao, Guoquan Gao, Xia Yang* (Corresponding author). Decreased K5 receptor expression in the retina, a potential pathogenic mechanism for diabetic retinopathy. Molecular Vision 2012; 18:330-336. (Impact factor 2.511) 18. Zhou T, He X, Cheng R, Zhang B, Zhang RR, Chen Y, Takahashi Y, Murray AR, Lee K, Gao G, Ma JX*. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012 Jan; 55(1):255-66. （IF:6.9） 19. Zumin Xu, Shuhuan Fang, Yufang Zuo, Yang Zhang, Rui Cheng, Qingsong Wang, Zhonghan Yang, Weibin Cai, Jianxing Ma, Xia Yang*, Guoquan Gao* (corresponding author). Combination of PEDF with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by down-regulating VEGF expression and angiogenesis. Cancer Sci, 2011 Oct; 102(10):1789-98. Epub 2011 Jul 29. [Epub ahead of print]. (Impact factor 3.8)