个人简历

现任中山大学医学院教授，博士生导师。在中山大学生命科学学院，于2006本科毕业，2011年获得博士学位。2011年至2015年在美国密歇根大学张建之教授实验室，从事博士后研究工作。

研究领域

研究兴趣集中在运用高通量测序技术研究关键的生物学基础问题，主要包括影响各种错误率（DNA突变率，RNA转录错误率，蛋白质翻译错误率）的因素、分子层次和细胞层次的异质性的产生与演化规律、单细胞测序与精准医学的应用等等。

近期论文

17. Chen X, Zhang J. The X to autosome expression ratio in haploid and diploid human embryonic stem cells. Mol. Biol. Evol. 2016 Sep; 33:3104-3107. 16. Chen X, Zhang J. The genomic landscape of position effects on protein expression level and noise in yeast. Cell Syst. 2016 May; 2:347-354 15. Chen X, Yang JR, Zhang J. Nascent RNA folding mitigates transcription associated mutagenesis. Genome Res. 2015 Oct; 26:50-59 14. Chen X, Zhang J. No X-chromosome dosage compensation in human proteomes. Mol. Biol. Evol. 2015 Feb; 32: 1456-60 13. Chen X, Zhang J. Mutation accumulation experiment supports elevated mutation rates at highly transcribed sites. (Letter to Editor) PNAS. 2014 Sep; 111: E4062 12. Yang JR, Chen X, Zhang J. Codon-by-codon modulation of translational speed and accuracy via mRNA folding. PLoS Biol. 2014 Jul; 12: e1001910 11. Chen X, Zhang J. Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome? Genome Biol. Evol. 2013 Nov; 5:2436-9 10. Chen X, Zhang J. No Gene-Specific Optimization of Mutation Rate in Escherichia coli. Mol. Biol. Evol. 2013 Mar; 30:1559-62 9. Park C, Chen X, Yang JR, Zhang J. Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly. PNAS. 2013 Feb; 110 (8): 678-86 8. Chen X, Zhang J. The ortholog conjecture is untestable by the current Gene Ontology but is supported by RNA sequencing data. PLOS Comput Biol. 2012 Nov; 8 (11): e1002784 7. Chen X, Chen Z, Chen H, Su Z, Yang J, Shi S, He X. Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes. Science. 2012 Mar; 335(6073):1235-8. 6. He X, Chen X, Xiong Y, Chen Z, Wang X, Shi S, Wang X, Zhang J. He et al. reply. Nat Genet. 2011 Nov; 43(12): 1171-2 5. Yang G, Zhou R, Tang T, Chen X, Ouyang J, He L, Li W, Chen S, Guo M, Li X, Zhong C, Shi S. Gene expression profiles in response to salt stress in Hibiscus tiliaceus. Plant Mol Biol Rep. 2011 Sep; 29 (3):609-17 4. Yang G, Chen X, Tang T, Zhou R, Chen S, Li W, Ouyang J , He L, Shi S. Comparative genomics of two ecologically differential populations of Hibiscus tiliaceus under salt stress. Funct Plant Biol. 2011 Mar; 38(3) 199-208 3. Xiong Y*, Chen X*, Chen Z, Wang X, Shi S, Wang X, Zhang J, He X. RNA sequencing shows no dosage compensation of the active X-chromosome. Nat Genet. 2010 Dec; 42(12):1043-7 (*Co-first authors) 2. Chen X, Shi S, He X. Evidence for gene length as a determinant of gene coexpression in protein complexes. Genetics. 2009 Oct; 183(2):751-4 1. Zhou R, Zeng K, Wu W, Chen X, Yang Z, Shi S, Wu CI. Population genetics of speciation in nonmodel organisms: I. Ancestral polymorphism in mangroves. Mol. Biol. Evol. 2007 Dec; 24(12):2746-54