个人简历

1990毕业于湖南医科大学，获学士学位；1995年及1999年先后于中山医科大学获医学硕士及医学博士学位。1995年至2001年在中山大学微生物学教研室历任助教及讲师；2001年至2003年在美国University of Pennsylvania做博士后研究工作；2003-2007在美国Thomas Jefferson University做研究助理

研究领域

主要研究方向为钙离子通道及其相关伴侣在神经元信号转导中作用机理的研究。原创性发现钙离子通道相关蛋白Endophilin在神经元递质回收过程中的作用机制；阐明了ENH蛋白在N-type钙离子通道与蛋白激酶ε相互作用中的调节机制。目前的研究兴趣主要集中在利用分子生物学、分子细胞生物学、电生理及分子发光影像技术等技术手段，研究神经元突触可塑性分子机理。

近期论文

1.Qi Tian, Ji-Feng Zhang, Jinjin Fan, Zhihong Song and Yuan Chen. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Neuroscience Bulletin. 2012, 28(5): 483-492 2. Jifeng Zhang, Jinjin Fan, Qi Tian, Zhihong Song, Ji-fang Zhang, Yuan Chen. Characterization of two distinct modes of endophilin in clathrin-mediated endocytosis. Cellular Signalling. 2012, 24(11): 2043–2050 3.Yuan Chen and Qi Tian. The role of Protein Kinase C epsilon in neural signal transduction and neurogenic diseases. Frontiers of Medicine. 2011. 5(1): 70-76 4.Yuan Chen, Lunbing Deng, Yuka Maeno-Hikichi, Meizan Lai, Shaohua Chang, Gong Chen and Ji-fang Zhang . Formation of an Endophilin- Ca2+ Channel Complex is Critical for Clathrin-Mediated Synaptic Vesicle Endocytosis. Cell. 2003, 115, 37-48 5.Yuan Chen, Meizan Lai, Yuka Maeno-Hikichi and Ji-fang Zhang. Essential role of the LIM domain in the formation of the PKCε–ENH–N- type Ca2+ channel complex. Cellular Signalling. 2006, 18(2): 215-224 6.Patrick J Loll; Evelyn Swain; Yuan Chen; Brain T Turner; Ji-fang Zhang. Structure of the SH3 domain of rat endophilin A2. Acta Crystallogr Sect F Struct Biol Cryst Commun.2008, 64(Pt 4):243-246 7.Meizan Lai, Fushun Wang, Joyce G Rohan, Yuka Maeno-Hikichi, Yuan Chen, Yi Zhou, Guangping Gao, William A Sather & Ji-fang Zhang. A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons. Nature Neuroscience. 2005, 8 (4): 435-442 8.Dongjun Li, Fushun Wang, Meizan Lai, Yuan Chen and Ji-fang Zhang. A Protein Phosphatase 2c -Ca2+ Channel Complex for Dephosphorylation of Neuronal Ca2+ Channels Phosphorylated by Protein Kinase C. J. Neurosci., 2005; 25: 1914 – 1923