个人简历
现任中山大学中山医学院教授，博士生导师，国家重点研发计划青年首席科学家。2007年于武汉大学生命科学学院获得学士学位；2012年于中科院上海生命科学研究院健康科学研究所获得细胞生物学博士学位，师从著名心脏疾病专家杨黄恬研究员；于2012年起在美国加州大学旧金山分校戴维•格拉斯通研究所（J. David Gladstone Institutes）从事博士后研究，导师为干细胞化学生物学奠基人丁胜教授。
研究领域
主要研究兴趣为利用化学生物学手段调控细胞命运和功能。研究工作主要集中在多能干细胞和体细胞向心血管前体细胞以及功能性心血管细胞重编程体系的建立、相关调控机制研究、以及其在治疗心脏疾病中的应用。
近期论文
1. Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int. 2017 Jun 5 doi: 10.1155/2017/1769298 (IF: 3.5) 2. Xu T, Stewart K, Wang X, Liu K, Xie Min, Ryu JK, Li K, Ma T, Wang H, Ni L, Zhu S, Cao N, Don W, Zhang Y, Akassoglou K, Dong C, Driggers EM and Ding S. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature 2017 Aug 2, doi:10.1038/nature23475 (IF: 40.1). 3. Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H, Ma T, Xu T, Shi G, Srivastava D, Ding S. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 2016 Jun 3;352(6290):1216-20 (IF: 37.2). 4. Zhang Y*, Cao N*, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S. Expandable cardiovascular progenitor cells reprogrammed from fibroblasts. Cell Stem Cell 2016 Mar 3;18(3):368-81 (IF: 23.4) (Featured article, highlighted by Yamashita JK. Expanding reprogramming to cardiovascular progenitors. Cell Stem Cell 2016 Mar 3;18(3):299-301. *equally contributing authors). 5. Zhang M, Lin YH, Sun YJ, Zhu S, Zheng J, Liu K, Cao N, Li K, Huang Y, Ding S. Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 2016 May 5;18(5):653-67 (IF: 23.4). 6. Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan KL, Ding S. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature Cell Biology 2015 Nov;17(11):1379-87 (IF: 20.1). 7. Cao N, Liang H, Yang HT. Generation, expansion, and differentiation of cardiovascular progenitor cells from human pluripotent stem cells.Methods in Molecular Biology 2015; 1212:113-25. 8. Wang H, Cao N, Spencer CI, Nie B, Ma T, Xu T, Zhang Y, Wang X, Srivastava D, Ding S. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Reports 2014 Mar 13;6(5):951-60 (IF: 8.3). 9. Cao N*, Liang H*, Huang J, Wang J, Chen Y, Chen Z, Yang HT. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Research 2013 Sep;23(9):1119-32 (IF: 15.6; *equally contributing authors). 10. Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Research 2012 Jan;22(1):219-36 (IF: 15.6). 11. Wang J, Cao N, Yuan M, Cui HJ, Tang Y, Qin LJ, Huang XF, Shen N, Yang HT. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-37 (IF: 3.6). 12. Cao N*, Liao J*, Liu ZM, Zhu WM, Wang J, Liu LJ, Yu LL, Xu P, Cui C, Xiao L, Yang HT. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Research 2011 Sep;21(9):1316-31 (IF: 15.6; *equally contributing authors). 13. Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death & Diff. 2010 Jul;17(7):1141-54 (IF: 8.3).
