个人简历

中南大学肿瘤研究所 研究员
湖南省杰出青年基金获得者、湖南省青年骨干教师
中南大学“升华育英”人才
British Journal of Cancer杂志编委
教育经历
[1] 2003.9-2005.12
中南大学 | 病理学与病理生理学 | 博士学位 | 博士研究生毕业
[2] 1999.9-2002.6
中南大学 | 病理学与病理生理学 | 硕士学位 | 硕士研究生毕业
[3] 1993.9-1997.6
湖南师范大学 | 生物系 | 学士学位 | 大学本科毕业
工作经历
[1] 2008.8-2009.7
美国犹他大学 | 医学院 | 博士后
[2] 2006.6-2008.7
美国阿肯色医科大学 | 博士后
[3] 1997.7-至今
中南大学 | 肿瘤研究所
科研项目
[1]国家自然科学基金面上项目：一个新的LncRNA分子通过编码小肽NBDY选择性调控mRNA脱帽促进鼻咽癌侵袭转移
[2]国家自然科学基金面上项目：长链非编码RNA LOC284454作为ceRNA促进鼻咽癌侵袭转移
[3]国家自然科学基金海外及港澳合作: 小分子药物调控miR-33/c-Myc的表达在髓母细胞瘤治疗中的作用和机制研究
[4]国家自然科学基金面上项目： BPIFB1基因通过CXCL12/CXCR4调节轴参与鼻咽癌发生发展的分子机制
[5]湖南省杰出青年基金：LPLUNC1在鼻咽癌中的抑瘤机制研究
[6]国家自然科学基金国际交流与合作：长链非编码RNA与肿瘤
[7]国家自然科学基金面上项目：罕见肿瘤家系中克隆的候选瘤基因TILZ4a致瘤机制研究
[8]国家自然科学基金面上项目：一个罕见多癌家系的分子遗传学研究
[9]国家自然科学基金面上项目：湖南鼻咽癌易感基因的进一步定位与克隆,国家自然科学基金
[10]国家自然科学基金青年基金：鼻咽癌相关单核苷酸多态性数据库的建立
专利成果
[1]促进环状RNA circRNF13表达的试剂在制备治疗舌鳞癌药物上的应用
[2]长链非编码RNA LOC284454的应用方法
[3]原位杂交检测口腔肿瘤组织中长链非编码RNA LINC00472试剂的应用
[4]原位杂交检测鼻咽癌组织中长链非编码RNA LOC284454试剂的应用
[5]长链非编码RNA LINC01420的原位杂交检测试剂及其应用
[6]一种鼻咽癌辅助诊断或者疗效预测用的生物标记物及其应用
[7]EB病毒编码的microRNA BART6-3p的应用
[8]长链非编码RNA LINC00673的siRNA的应用及抑制制剂
[9]一种长链非编码RNA LINC00152的应用
[10]检测鼻咽癌患者血清中长链非编码RNA LOC284454表达量的试剂的应用
[11]检测鼻咽癌组织中长链非编码RNA LOC284454表达量的试剂的应用
[12]EB病毒编码的microRNA BART6-3p在制备鼻咽癌细胞抑制剂上的应用
[13]BTRC基因的过表达试剂及其制备和应用方法
[14]长链非编码RNA AFAP1-AS1在制备乳腺癌辅助诊断及预后判断制剂上的应用
[15]长链非编码RNA基因LOC553103在制备鼻咽癌预后制剂上的应用
[16]长链非编码RNA LOC401317引物的应用方法
[17]长链非编码RNA LOC401317原位杂交探针的应用方法
[18]一个长链非编码RNA基因及其应用方法
著作成果
[1]非编码RNA与肿瘤,科学出版社,2020
[2]Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects[编著],2020
[3]癌症-基础卷（译著）,科学出版社,2020
[4]现代肿瘤学基础,科学出版社,2020
[5]基于WWW的生物信息学应用指南,中南大学出版社,2020
教学成果
[1]湖南省优秀硕士学位论文奖（2018年，硕士生孛昊）
[2]第五届全国大学生基础医学创新论坛暨实验设计大赛一等奖
[3]第四届全国大学生基础医学创新论坛暨实验设计大赛一等奖
获奖信息
[1]湖南省自然科学奖二等奖：长链非编码RNA在头颈肿瘤中的作用机制研究
[2]湖南省优秀博士学位论文奖(2007)：3p21区域鼻咽癌候选易感基因的筛选及全基因组表达谱对鼻咽癌候选分子标志物的鉴定,曾朝阳

研究领域

"EBV与鼻咽癌
非编码RNA与肿瘤
恶性肿瘤的免疫逃逸机制"

近期论文

[1].Wei F, Wang D, Wei J, Tang N, Tang L, Xiong F, Guo C, Zhou M, Li X, Li G, Xiong W, Zhang S*, Zeng Z*. Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance:Cell Mol Life Sci,2020
[2].Zhu K, Li P, Mo Y, Wang J, Jiang X, Ge J, Huang W, Liu Y, Tang Y, Gong Z, Liao Q, Li X, Li G, Xiong W, Zeng Z*, Yu J*. Neutrophils: Accomplices in metastasis:Cancer Lett,2020,492:11-20
[3].Tang T, Yang L, Cao Y, Wang M, Zhang S, Gong Z, Xiong F, He Y, Zhou Y, Liao Q, Xiang B, Zhou M, Guo C, Li X, Li Y, Xiong W, Li G, Zeng Z*. LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma:Mol Oncol.
[4]Zhao J, Guo C, Xiong F, Yu J, Ge J, Wang H, Liao Q, Zhou Y, Gong Q, Xiang B, Zhou M, Li X, Li G.Xiong W*, Fang J*, Zeng Z*. Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma:Cancer Lett. 2020 May 1,477:131-143
[5]Zhou B, Yuan Y, Zhang S, Guo C, Li X, Li G, Xiong W, Zeng Z*.Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract:Front Immunol, 2020 Apr 3,11:575
[6]Ge J, Wang J, Wang H, Jiang X, Liao Q, Gong Q, Mo Y, Li X, Li G, Xiong W, Zhao J*, Zeng Z*.The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancer:J Cancer. 2020 Jan 1,11(4):932-939
[7]Peng M, Mo Y, Wang Y, Wu P, Zhang Y, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Xiong W, Zeng Z*.Neoantigen vaccine: an emerging tumor immunotherapy:Mol Cancer. 2019 Aug 23,18(1):128
[8]Xiao L, Wei F, Liang F, Li Q, Deng H, Tan S, Chen S, Xiong F, Guo C, Liao Q, Li X, Zhang W, Wu M.Zhou Y, Xiang B, Zhou M, Li X, Xiong W, Zeng Z*, Li G*. TSC22D2 identified as a candidate susceptibility gene of multi-cancer pedigree using genome-wide linkage analysis and whole-exome sequencing:Carcinogenesis. 2019 Jul 20,40(7):819-827
[9]Wang W, Zhou R, Wu Y, Liu Y, Su W, Xiong W*, Zeng Z*.PVT1 Promotes Cancer Progression via MicroRNAs:Front Oncol. 2019 Jul 15,9:609
[10]Fan CM, Wang JP, Tang YY, Zhao J, He SY, Xiong F, Guo C, Xiang B, Zhou M, Li XL, Li Y, Li GY.Xiong W*, Zeng ZY*. circMAN1A2 could serve as a novel serum biomarker for malignant tumors:Cancer Sci. 2019 Jul,110(7):2180-2188
[11]Fan C, Tu C, Qi P, Guo C, Xiang B, Zhou M, Li X, Wu X, Li X, Li G, Xiong W, Zeng Z*.GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma:J Cancer. 2019 Jun 24,10(17):3926-3932
[12]Mo Y, Wang Y, Xiong F, Ge X, Li Z, Li X, Li Y, Li X, Xiong W, Li G, Zeng Z*, Guo C*.Proteomic Analysis of the Molecular Mechanism of Lovastatin Inhibiting the Growth of Nasopharyngeal Carcinoma Cells:J Cancer. 2019 May 26,10(10):2342-2349
[13]Fan C, Tang Y, Wang J, Wang Y, Xiong F, Zhang S, Li X, Xiang B, Wu X, Guo C, Ma J, Zhou M, Li X.Xiong W, Li Y, Li G, Zeng Z*. Long non-coding RNA LOC284454 promotes migration and invasion of nasopharyngeal carcinoma via modulating the Rho/Rac signaling pathway:Carcinogenesis. 2019 Apr 29,40(2):380-391
[14]Xia M, Zhang Y, Jin K, Lu Z, Zeng Z*, Xiong W*.Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer:Cell Biosci. 2019 Mar 19,9(27)
[15]Wei F, Jing YZ, He Y, Tang YY, Yang LT, Wu YF, Tang L, Shi L, Gong ZJ, Guo C, Zhou M, Xiang B, Li XL.Li Y, Li GY, Xiong W, Zeng ZY*, Xiong F*. Cloning and characterization of the putative AFAP1-AS1 promoter region:J Cancer. 2019 Jan 29,10(5):1145-1153
[16]Jiang X, Wang J, Deng X, Xiong F, Ge J, Xiang B, Wu X, Ma J, Zhou M, Li X, Li Y, Li G, Xiong W.Guo C*, Zeng Z*. Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape:Mol Cancer. 2019 Jan 15,18(1):10
[17]Deng X, Xiong F, Li X, Xiang B, Li Z, Wu X, Guo C, Li X, Li Y, Li G, Xiong W*, Zeng Z*.Application of atomic force microscopy in cancer research:J Nanobiotechnology. 2018 Dec 11,16(1):102
[18]Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, Guo C, Xiang B, Zhou M, Ma J, Huang X, Wu X, Li Y.Li GY, Zeng ZY*, Xiong W*. Effects of tumor metabolic microenvironment on regulatory T cells:Mol Cancer. 2018 Nov 26,17(1):168
[19]Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Xiang B, Zhou M, Li X, Wu X, Li Y, Li X, Li G.Xiong W*, Zeng Z*. The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma:J Cancer. 2018 Jul 30,9(16):2852-2864
[20]Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y, Fan C, Li X, Li G, Li Y, Xiong W*, Zeng Z*.Circular RNAs (circRNAs) in cancer:Cancer Lett. 2018 Jul 1,425:134-142
[21]Tang L, Wei F, Wu Y, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Deng H, Cao K, Zhou M, Xiang B, Li X.Li Y, Li G, Xiong W*, Zeng Z*. Role of metabolism in cancer cell radioresistance and radiosensitization methods:J Exp Clin Cancer Res. 2018 Apr 23,37(1):87
[22]Zhong Y, Du Y, Yang X, Mo Y, Fan C, Xiong F, Ren D, Ye X, Li C, Wang Y, Wei F, Guo C, Wu X, Li X.Li Y, Li G, Zeng Z*, Xiong W*. Circular RNAs function as ceRNAs to regulate and control human cancer progression:Mol Cancer. 2018 Apr 7,17(1):79
[23]Wei F, Tang L, He Y, Wu Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Ni Q, Luo J, Li X.Li Y, Peng C, Chen X, Li G, Xiong W*, Zeng Z*. BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression:Cell Death Dis. 2018 Apr 1,9(4):432
[24]Zhang Y, Xia M, Jin K, Wang S, Wei H, Fan C, Wu Y, Li X, Li X, Li G, Zeng Z*, Xiong W*.Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities:Mol Cancer. 2018 Feb 19,17(1):45
[25]He Y, Jing Y, Wei F, Tang Y, Yang L, Luo J, Yang P, Ni Q, Pang J, Liao Q, Xiong F, Guo C, Xiang B.Li X, Zhou M, Li Y, Xiong W, Zeng Z*, Li G*. Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma:Cell Death Dis. 2018 Feb 14,9(2):235
[26]Wei F, Wu Y, Tang L, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Zhou M, Xiang B.Li X, Li Y, Li G, Xiong W*, Zeng Z*. BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM:Br J Cancer. 2018 Jan,118(2):233-247
[27]Wei F, Wu Y, Tang L, Xiong F, Guo C, Li X, Zhou M, Xiang B, Li X, Li G, Xiong W*, Zeng Z*.Trend analysis of cancer incidence and mortality in China:Sci China Life Sci. 2017 Nov,60(11):1271-1275
[28]He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z*, Tang H*..circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a:J Exp Clin Cancer Res. 2017 Oct 16,36(1):145
[29]Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Zhang S, Gong Z, Wei F, Yang L, He Y, Zhou M, Li X.Li G, Xiong W*, Zeng Z*. Role of long non-coding RNAs in glucose metabolism in cancer:Mol Cancer. 2017 Jul 24,16(1):130
[30]Tang Y, He Y, Shi L*, Yang L, Wang J, Lian Y, Fan C, Zhang P, Guo C, Zhang S, Gong Z, Li X, Xiong F.Li X, Li Y, Li G, Xiong W, Zeng Z*. Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma:Oncotarget. 2017 Jun 13,8(24):39001-39011
[31]Yu J, Liu Y, Gong Z, Zhang S, Guo C, Li X, Tang Y, Yang L, He Y, Wei F, Wang Y, Liao Q, Zhang W.Li X, Li Y, Li G, Xiong W*, Zeng Z*. Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma:Oncotarget. 2017 Mar 7,8(10):16621-16632
[32]Wang M, Zhao J, Zhang L, Wei F, Lian Y, Wu Y, Gong Z, Zhang S, Zhou J, Cao K, Li X, Xiong W, Li G.Zeng Z*, Guo C*. Role of tumor microenvironment in tumorigenesis:J Cancer. 2017 Feb 25,8(5):761-773
[33]Tang Y, Wang J, Lian Y, Fan C, Zhang P, Wu Y, Li X, Xiong F, Li X, Li G, Xiong W*, Zeng Z*.Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer:Mol Cancer. 2017 Feb 17,16(1):42
[34]Wang Y, Mo Y, Gong Z, Yang X, Yang M, Zhang S, Xiong F, Xiang B, Zhou M, Liao Q, Zhang W, Li X, Li X.Li Y, Li G, Zeng Z*, Xiong W*. Circular RNAs in human cancer:Mol Cancer. 2017 Jan 31,16(1):25
[35]Yang L, Tang Y, He Y, Wang Y, Lian Y, Xiong F, Shi L, Zhang S, Gong Z, Zhou Y, Liao Q, Zhou M, Li X.Xiong W, Li Y, Li G, Zeng Z*, Guo C*. High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma:J Cancer. 2017 Jan 1,8(1):97-103
[36]He B, Li W, Wu Y, Wei F, Gong Z, Bo H, Wang Y, Li X, Xiang B, Guo C, Liao Q, Chen P, Zu X, Zhou M.Ma J, Li X, Li Y, Li G, Xiong W*, Zeng Z*. Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103:Cell Death Dis. 2016 Sep 1,7(9):e2353
[37]Liang F, Li Q, Li X, Li Z, Gong Z, Deng H, Xiang B, Zhou M, Li X, Li G, Zeng Z*, Xiong W*.TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer:Int J Oncol. 2016 Sep,49(3):1046-56
[38]Wang Y, Xue D, Li Y, Pan X, Zhang X, Kuang B, Zhou M, Li X, Xiong W, Li G, Zeng Z*, Yang T*.The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various Cancers: A Meta-analysis Based on the GEO Database and Literature:J Cancer. 2016 May 20,7(8):991-1001
[39]Gong Z, Yang Q, Zeng Z*, Zhang W, Li X, Zu X, Deng H, Chen P, Liao Q, Xiang B, Zhou M, Li X, Li Y.Xiong W, Li G. An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma:Tumour Biol. 2016 Mar,37(3):3683-95
[40]Zhou Y, Liao Q, Li X, Wang H, Wei F, Chen J, Yang J, Zeng Z*, Guo X, Chen P, Zhang W, Tang K, Li X.Xiong W, Li G*. HYOU1, Regulated by LPLUNC1, Is Up-Regulated in Nasopharyngeal Carcinoma and Associated with Poor Prognosis:J Cancer. 2016 Jan 12,7(4):367-76
[41]Xu K, Xiong W, Zhou M, Wang H, Yang J, Li X, Chen P, Liao Q, Deng H, Li X, Li G, Zeng Z*.Integrating ChIP-sequencing and digital gene expression profiling to identify BRD7 downstream genes and construct their regulating network:Mol Cell Biochem. 2016 Jan,411(1-2):57-71
[42]Yan Q, Zeng Z*, Gong Z, Zhang W, Li X, He B, Song Y, Li Q, Zeng Y, Liao Q, Chen P, Shi L, Fan S.Xiang B, Ma J, Zhou M, Li X, Yang J, Xiong W, Li G*. EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC:Oncotarget. 2015 Dec 8,6(39):41766-82
[43]Bo H, Gong Z, Zhang W, Li X, Zeng Y, Liao Q, Chen P, Shi L, Lian Y, Jing Y, Tang K, Li Z, Zhou Y.Zhou M, Xiang B, Li X, Yang J, Xiong W, Li G, Zeng Z*. Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma:Oncotarget. 2015 Aug 21,6(24):20404-18
[44]Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, Fan S, Shi L, Li X, Zhang P, Zhou Y, Huang D.Liang F, Zhang X, Wu M, Cao L, Wang J, Li Y, Xiong W, Zeng Z*, Li G*. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma:J Mol Histol. 2013 Oct,44(5):545-54
[45]Yang Y, Liao Q, Wei F, Li X, Zhang W, Fan S, Shi L, Li X, Gong Z, Ma J, Zhou M, Xiang J, Peng S.Xiang B, Deng H, Yang Y, Li Y, Xiong W, Zeng Z*, Li G*. LPLUNC1 inhibits nasopharyngeal carcinoma cell growth via down-regulation of the MAP kinase and cyclin D1/E2F pathways:PLoS One. 2013 May 1,8(5):e62869
[46]Gong Z, Zhang S, Zhang W, Huang H, Li Q, Deng H, Ma J, Zhou M, Xiang J, Wu M, Li X, Xiong W, Li X.Li Y, Zeng Z*, Li G*. Long non-coding RNAs in cancer:Sci China Life Sci. 2012 Dec,55(12):1120-4
[47]Zeng Z, Huang H, Zhang W, Xiang B, Zhou M, Zhou Y, Ma J, Yi M, Li X, Li X, Xiong W*, Li G*.Nasopharyngeal carcinoma: advances in genomics and molecular genetics:Sci China Life Sci. 2011 Oct,54(10):966-75
[48]Zeng Z, Velarde MC, Simmen FA, Simmen RC.Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9:Biol Reprod. 2008 Jun,78(6):1029-37
[49]Zeng Z, Zhou Y, Xiong W, Luo X, Zhang W, Li X, Fan S, Cao L, Tang K, Wu M, Li G*.Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray:J Cancer Res Clin Oncol. 2007 Feb,133(2):71-81
[50]Zeng ZY, Zhou YH, Zhang WL, Xiong W, Fan SQ, Li XL, Luo XM, Wu MH, Yang YX, Huang C, Cao L, Tang K.Qian J, Shen SR, Li GY. Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated Wnt signaling pathway:Hum Pathol. 2007 Jan,38(1):120-33
[1]   British Journal of Cancer 杂志编委