个人简历

教育背景\r
201409-201904，伦敦大学学院，生物化工专业，博士学位\r
201109-201406，天津大学，生物化工专业，硕士学位\r
200709-201107，天津大学，生物工程专业，学士学位\r
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工作经历\r
202008-至今，浙江大学，化学工程与生物工程学院，“研究员，博导\r
201807-202007，伦敦大学学院，化学系，博士后研究员\r
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研究领域

"""""1. 酶分子的智能化设计方法开发。\r
2. 探索非天然氨基酸在酶工程领域的应用"

近期论文

Wenlong Zheng#, Zhongji Pu#, Lanxin Xiao,Gang Xu, Lirong Yang, Haoran Yu*, Jianping Wu*. Mutability-Landscape-Guided Engineering of l-Threonine Aldolase Revealing the Prelog Rule in Mediating Diastereoselectivity of C-C Bond Formation. Angewandte Chemie International Edition, 2022.11.11 https://doi.org/10.1002/ange.202213855 (IF 16.823 )\r
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Kudakwashe Nyandoro, Charles M. G. Lamb, Haoran Yu, Jian Shi and Derek Macmillan*. Investigation of acyl transfer auxiliary-assisted glycoconjugation for glycoprotein semi-synthesis. Organic & Biomolecular Chemistry, 2022. DOI: 10.1039/d2ob01633h\r
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Ziyuan Wang, Haisheng Zhou*, Haoran Yu, Zhongji Pu, Jinling Xu, Hongyu Zhang, Jianping Wu, and Lirong Yang*. Computational Redesign of the Substrate Binding Pocket of Glutamate Dehydrogenase for Efficient Synthesis of Noncanonical L‑Amino Acids. ACS Catalysis, 2022, 12, 13619-13629 (IF 13.7)\r
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Wenlong Zheng, Zhongji Pu, Lanxin Xiao, Gang Xu, Li-Rong Yang, Haoran Yu*, Jianping Wu*. Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity. Chemical Communications. 2022.06.24 https://doi.org/10.1039/D2CC02644A (IF 6.222)\r
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Xiumiao Yao, Tingting Kang, Zhongji Pu, Tao Zhang, Jianping Lin, Lirong Yang, Haoran Yu*, and Mianbin Wu*. Sequence and Structure-Guided Engineering of Urethanase from Agrobacterium tumefaciens d3 for Improved Catalytic Activity. Journal of Agricultural and Food Chemistry, 2022. https://doi.org/10.1021/acs.jafc.2c01406 (IF 5.279)\r
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Yun Feng, Zhongji Pub, Li Zhu, Mianbin Wu, Lirong Yang, HaoranYu*, Jianping Lin*. Enhancing the thermostability of D-allulose 3-epimerase from Clostridium cellulolyticum H10 via a dual-enzyme screening system. Enzyme and Microbial Technology, 2022. https://doi.org/10.1016/j.enzmictec.2022.110054 (IF 3.493)\r
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Zhonglang Yu#, Haoran Yu#, Jinling Xu, Zhe Wang, Ziyuan Wang, Tingting Kang, Kaitong Chen, Zhongji Pu, Jianping Wu, Li-Rong Yang, Gang Xu*. Enhancing Thermostability of Lipase from Pseudomonas alcaligenes for producing L-menthol by the CREATE Strategy. Catalysis Science & Technology, 2022. https://doi.org/10.1039/D2CY00082B (IF 6.119)\r
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Haoran Yu*, Shuang Ma, Yiwen Li, Paul A. Dalby*. Hot spots-making directed evolution easier. Biotechnology Advances, 2022. https://doi.org/10.1016/j.biotechadv.2022.107926 (IF 17.681)\r
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Ke Liu, Haoran Yu, Guoyun Sun, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv*, Long Liu*. Semi-rational design of L-amino acid deaminase for production of pyruvate and D-alanine by Escherichia coli whole-cell biocatalyst. Amino Acids, 2021. https://doi.org/10.1007/s00726-021-03067-8\r
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Cheng Zhang, Nuria Codina, Jiazhi Tang, Haoran Yu, Nesrine Chakroun, Frank Kozielski, Paul A. Dalby*. Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation. Computational and Structural Biotechnology Journal, 2021. DOI: 10.1016/j.csbj.2021.05.005.\r
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Zhonglang Yu, Haoran Yu, Haibin Tang, Zhe Wang, Jianping Wu, Lirong Yang, Gang Xu*. Site‐specifically Incorporate Non‐Canonical Amino Acids into Pseudomonas alcaligenes Lipase to Hydrolyze L‐ menthol propionate among the Eight Isomers. ChemCatChem, 2021.\r
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Wenlong Zheng, Haoran Yu, Sai Fang, Kaitong Chen, Zhe Wang, Xiuli Cheng, Gang Xu*, Lirong Yang, and Jianping Wu*. Directed Evolution of l-Threonine Aldolase for the Diastereoselective Synthesis of β-Hydroxy-α-amino Acids. ACS Catalysis, 2021, 11, XXX, 3198–3205\r
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Jinling Xu, Haisheng Zhou*, Haoran Yu, Tong Deng, Ziyuan Wang, Hongyu Zhang, Jianping Wu, Lirong Yang*. Computational design of highly stable and soluble alcohol dehydrogenase for NADPH regeneration. Bioresour. Bioprocess, 8, 12 (2021).\r
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Haoran Yu, Paul A Dalby*. A beginner's guide to molecular dynamics simulations and the identification of cross-correlation networks for enzyme engineering. Methods in Enzymology, 2020.\r
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Haoran Yu, Roberto Icken Hernandez Lopez, David Steadman, Daniel Mendez-Sanchez, Sally Higson, Armando Cazares-Korner, Tom D. Sheppard, John M Ward, Helen C Hailes, Paul A Dalby*. Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α-hydroxyketones. The FEBS Journal, 2020, 287 (9): 1758-1776. （IF:5.54）\r
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Haoran Yu, Paul A. Dalby*. Exploiting correlated molecular-dynamics networks to counteract enzyme activity-stability trade-off. Proceedings of the National Academy of Sciences, 2018, 115 (52): E12192- E12200. (IF 11.205)\r
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Haoran Yu, Paul A. Dalby*. Coupled molecular dynamics mediate long and short-range epistasis between mutations that affect stability and aggregation kinetics. Proceedings of the National Academy of Sciences, 2018, 115 (47) : E11043-E11052. (IF 11.205)\r
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Lin Liu, Haoran Yu, Kun Du, Zhiyan Wang, Yiru Gan, He Huang*. Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region. Microbial cell factories, 2018, 17 (1): 165-174.\r
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Cheng Zhang, Maariyah Samad, Haoran Yu, Nesrine Chakroun, David Hilton, and Paul A. Dalby*. Computational-design to reduce conformational flexibility and aggregation rates of an antibody Fab fragment. Molecular pharmaceutics, 2018, 15 (8): 3079-3092.\r
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Haoran Yu, Yihan Yan, Cheng Zhang, Paul A. Dalby*. Two strategies to engineer flexible loops for improved enzyme thermostability. Scientific Reports 7, Article number: 41212 (2017) doi:10.1038/srep41212.