个人简历

1. 学习经历: 09/1988–06/1992 杭州大学生物系生物工程专业, 获理学学士学位 09/1992–06/1995 杭州大学生物科学与技术系遗传学专业, 获理学硕士学位 06/1997–09/2001 澳大利亚弗林德斯大学医学生化系(Department of Medical Biochemistry, Flinders University),获博士学位(Ph.D.) \r
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2. 工作经历: 07/1995–04/1997 杭州高乐生化制品有限公司, 高级技术员 10/2001–10/2004 美国德州大学西南医学中心生理学系(Department of Physiology, University of Texas Southwestern Medical Center at Dallas),博士后 11/2004–05/2009 美国默克制药公司默克研究所抗病毒研究系(Department of Antiviral Research, Merck Research Laboratories, Merck & Co., Inc.), 资深科学家（Senior Research Biochemist） 06/2009–现在 浙江大学医学院研究员；传染病诊治国家重点实验室PI 05/2012–现在 感染性疾病诊治协同创新中心PI

研究领域

胞内外信号调控干细胞增殖与分化 核心干性转录因子在肿瘤干细胞中的作用 艾滋病宿主因子作用机理与新药研发""

近期论文

Pan X, Cang X, Dan S, Li J, Cheng J, Kang B, Duan X, Shen B, Wang YJ. Site-specific disruption of the Oct4-Sox2 interaction reveals coordinated mesendodermal differentiation and the epithelial to mesenchymal transition. Under revision at Stem Cell Reports. \r
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Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ. (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nature Communications, in press. \r
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Zhao QW, Zhou YW, Li WX, Yang Y, Cheng J, Zhang XQ, Yin SY, Tong Y, He JQ, Kang B, Yao HP, Zheng M, Wang YJ. (2015) Akt-mediated phosphorylation of Oct4 is associated with the proliferation of stem-like cancer cells. Oncology Reports, 33(4): 1621-1629. \r
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Dan S, Kang B, Duan X, Wang YJ. (2015) A cell-free system toward deciphering the post-translational modification barcodes of Oct4 in different cellular contexts. Biochemical and Biophysical Research Communications, 456(3):714-720. \r
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Lin Y, Yang Y, Li W, Chen Q, Li J, Pan X, Zhou L, Liu C, Chen C, He J, Cao H, Yao H, Zheng L, Xu X, Xia Z, Ren J, Xiao L, Li L, Shen B, Zhou H, Wang YJ. (2012) Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Molecular Cell, 48(4):627-640. \r
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Wang YJ, Li WH, Wang J, Xu K, Dong P, Luo X, Yin HL (2004) Critical role of PIP5KIg87 in InsP3-mediated Ca2+ signaling. Journal of Cell Biology, 167(6): 1005-1010. \r
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Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL (2003) Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell, 114(3): 299-310. \r
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Padron D, Wang YJ, Yamamoto M, Yin H, Roth MG (2003) Phosphatidylinositol phosphate 5-kinase Ib recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. Journal of Cell Biology, 162(4): 693-701. \r
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Wang YJ, Gregory RB, Barritt GJ (2002) Maintenance of the filamentous actin cytoskeleton is necessary for the activation of store-operated Ca2+ channels, but not other types of plasma-membrane Ca2+ channels, in rat hepatocytes. Biochemical Journal, 363(Pt1): 117-126. \r
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Wang J, Zhou L, Li Z, Zhang T, Liu W, Liu Z, Yuan YC, Su F, Xu L, Wang Y, Zhou X, Xu H, Hua Y, Wang YJ, Zheng L, Teng YE, Shen B. (2015) YY1 suppresses FEN1 over-expression and drug resistance in breast cancer. BMC Cancer, 15:50. \r
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Su T, Dan S, Wang Y. (2014) Akt–Oct4 regulatory circuit in pluripotent stem cells. Chinese Science Bulletin, 59(10):936-943. \r
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Cao H, Ma J, Yang J, Su X, Chen D, Yu J, Pan Q, Shao L, Zhou P, Li J, Wang Y, Li L. (2014) A metabonomics study of Chinese miniature pigs with acute liver failure treated with transplantation of placental mesenchymal stem cells. Metabolomics, 10(4):651-662. \r
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Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. (2013) Enhancement of Antiviral Activity of Human Alpha-defensin 5 against Herpes Simplex Virus Type 2 by Arginine Mutagenesis at Adaptive Evolution Sites. Journal of Virology, 87(5):2835-2845. \r
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Yang Y, Li J, Pan X, Zhou P, Yu X, Cao H, Wang Y, Li L. (2013) Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system. Biotechnology & Bioengineering, 110(3):958-968. \r
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Yang H, Liu C, Jamsen J, Wu Z, Wang Y, Chen J, Zheng L, Shen B. (2012) The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell Cycle, 11(24):4626-4632. \r
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Draz MS, Fang BA, Li L, Chen Z, Wang Y, Xu Y, Yang J, Killeen K, Chen FF. (2012) Hybrid nanocluster plasmonic resonator for immunological detection of hepatitis B virus. ACS Nano, 6(9):7634-7643. \r
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Guo Z, Kanjanapangka J, Liu N, Liu S, Liu C, Wu Z, Wang Y, Loh T, Kowolik C, Jamsen J, Zhou M, Truong K, Chen Y, Zheng L, Shen B. (2012) Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression. Molecular Cell, 47(3):444-456. \r
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Yu J, Cao H, Yang J, Pan Q, Ma J, Li J, Li Y, Li J, Wang Y, Li L. (2012) In vivo hepatic differentiation of mesenchymal stem cells from human umbilical cord blood after transplantation into mice with liver injury. Biochemical and Biophysical Research Communications, 422(4):539-545. \r
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Cao H, Yang J, Yu J, Pan Q, Li J, Zhou P, Li Y, Li J, Wang Y, Li L. (2012) Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure. BMC Medicine, 10:56.