研究领域

药物制剂
功能化高分子与药物递送

近期论文

Loading docetaxel in beta-cyclodextrin-based micelles for enhanced oral chemotherapy through inhibition of P-glycoprotein mediated efflux transport, Lu Zhang, Yurun Shen, Liyan Qiu*, RSC Advances, 2017, 7(42): 26161-26169
In Situ-Generated Gold Nanoparticle Hybrid Polymersomes for Water-Soluble Chemotherapeutics: Inhibited Leakage and pH-Responsive Intracellular Release, Jun Fu, Lina Liang, and Liyan Qiu*, Advanced Functional Materials, 2017, 27(18): 1604981
Sensitization of Multidrug-Resistant Malignant Cells by Liposomes Co-encapsulating Doxorubicin and Chloroquine through Autophagic Inhibition, Menghua Gao, Yuzhen Xu, Liyan Qiu*, Journal of Liposome Research, 2017, 27(2):151-160
Drug-resistance reversal by combretastatin-A4 phosphate loaded with doxorubicin in polymersomes independent of angiogenesis effect, Jinfang Zhu, Mengying Hu, LI YAN QIU*, Journal of Pharmacy and Pharmacology, 2017, 69(7):844-855
Water-Soluble Combretastatin A4 Phosphate Orally Delivered via Composite Nanoparticles with Improved Inhibition Effect towards S180 Tumors, Yurun Shen, Liping Wu, and Liyan Qiu*, Journal of Pharmaceutical Sciences, 2017, 106: 3076-3083
Reverse micelle-in-microspheres with sustained release of water- soluble combretastatin A4 phosphate for S180 tumor treatment, Liping Wu, Liyan Qiu*, Journal of Materials Chemistry B, 2016, 4:760-767
Synergistic effects of A-B-C type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma, Lu Zhang, Jiafei Lu, Liyan Qiu*, International Journal of Nanomedicine, 2016, 11, 5205-5220
Polyphosphazene vesicles for co-delivery of doxorubicin and chloroquine with enhanced anticancer efficacy by drug resistance reversal, Jing Xu, Xiumei Zhu, and Liyan Qiu*, International Journal of Pharmaceutics, 2016, 498(1-2):70-81
Polymersomes via Self-Assembly of Amphiphilic -Cyclodextrin-Centered Tri-Arm Star Polymers for Enhanced Oral Bioavailability of Water-Soluble Chemotherapeutics，Mengying Hu,Yurun Shen, Lu Zhang, and Liyan Qiu*, Biomacromolecules，2016, 17(3), 1026-1039
Constructing aptamer anchored nanovesicles for enhanced tumor penetration and cellular uptake of water soluble chemotherapeutics, Xin Li, Xiumei Zhu, Liyan Qiu*, Acta Biomaterialia, 2016, 35: 269-279
Cationic Polyphosphazene Vesicles for Cancer Immunotherapy by Efficient in Vivo Cytokine IL-12 Plasmid DNA Delivery, Menghua Gao, Xiumei Zhu, Liping Wu, Liyan Qiu*, Biomacromolecules, 2016, 17(6), 2199-2209
Mechanism study of PEGylated polyester and β-cyclodextrin integrated micelles on drug resistance reversal in MRP1-overexpressed HL60/ADR cells, Qian Ji, Liyan Qiu*, Colloids and Surfaces B: Biointerfaces, 2016, 144: 203-213
Optimizing particle size of docetaxel-loaded micelles for enhanced treatment of oral epidermoid carcinoma, Yang Yu, Liyan Qiu*, Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 12(7): 1941-1949
Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cancer, Biomaterials, Yan Peng, Xiumei Zhu, Liyan Qiu*, Biomaterials, 2016, 106: 1-12
Sequentially dual-targeting vectors with nano-in-micro structure for improved docetaxel oral delivery in vivo, Yurun Shen, Mengying Hu, Liyan Qiu*, Nanomedicine, 2016, 11(23): 3071-3086
Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic 127/cyclodextrin-linked polymer composite micelles，Nanomedicine: Nanotechnology, Biology, and Medicine，Xin Li, Yang Yu, Qian Ji, Liyan Qiu*, 2015, 11(1): 175-184
Indocyanine green targeted micelles with improved stability for near infrared image-guided photothermal tumor therapy, Lu Yan, Liyan Qiu*, Nanomedicine, 2015, 10(3): 361-373
Thermo-responsive triblock copolymer micelles containing PEG6000 for either water-soluble or water-insoluble drug sustained release and treatment, Jun Fu, Xinyi Lv, Liyan Qiu*, RSC Adv., 2015, 5: 37451-37461
Nonspecifically enhanced therapeutic effects of vincristine on multidrug resistant cancers when co-encapsulated with quinine in liposomes, Yuzhen Xu, Liyan Qiu*, International Journal of Nanomedicine, 2015:10: 4225–4237
Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroquine co-delivery via liposomes, International Journal of Nanomedicine, Menghua Gao, Yuzhen Xu, Liyan Qiu*, 2015:10: 6615-6632
Co-encapsulation of combretastatin-A4 phosphate and doxorubicin in polymersomes for synergistic therapy of nasopharyngeal epidermal carcinoma, Jinfang Zhu, Xiaoping Xu, Mengying Hu, and Liyan Qiu*, Journal of Biomedical Nanotechnology, 2015 11(6), 997-1006