个人简历

李方园，博士生导师，浙江省杰出青年科学基金获得者，主要从事多功能纳米材料的制备及其生物医药应用的研究。迄今，发表论文84篇，总引＞3000次，其中IF>10的论文48篇，以通讯作者或第一作者（含并列）在Nature Nanotechnology (IF=39.213), Advanced Materials (IF=30.849), Advanced Drug Delivery Reviews (IF=15.47), Journal of the American Chemical Society (IF=15.419), ACS Nano (IF=15.881), ACS Central Science (IF=14.553), Nano Letters (IF=11.189)等国际著名刊物上发表论文53篇，授权专利共27项。担任中国生物物理学会材料生物学与智能诊疗技术分会委员兼秘书长、浙江省药学会药剂专业委员会青年委员。作为项目负责人承担国家级和省级自然科学基金项目多项。

研究领域

"""""主要从事多功能纳米材料的制备及其生物医药应用的研究"

近期论文

Lingxiao Zhang#, Jing Zhao#, Xi Hu#, Chenhan Wang#, Yingbo Jia, Chaojie Zhu, Shangzhi Xie, Jiyoung Lee, Fangyuan Li*, and Daishun Ling*. A Peritumorally Injected Immunomodulating Adjuvant Elicits Robust and Safe Metalloimmunotherapy Against Solid Tumors, Advanced Materials, 2022, in press.\r
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Xi Hu#, Nan Wang#, Xia Guo#, Zeyu Liang#, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling*, Fangyuan Li*. A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy, Nano-Micro Letters, 2022, 14, 101.\r
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Qiyue Wang#, Fangyuan Li#*, Zeyu Liang, Hongwei Liao, Bo Zhang, Peihua Lin, Xun Liu, Shen Hu, Jiyoung Lee, Daishun Ling*. A K+-sensitive AND-gate dual-mode imaging probe for simultaneous tumor imaging and malignancy identification, National Science Review, 2022, 9: nwac080. \r
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Haibin Wu#, Fan Xia#, Lingxiao Zhang#, Chunyan Fang, Jiyoung Lee, Linji Gong, Jianqing Gao*, Daishun Ling*, Fangyuan Li*, A ROS-Sensitive Nanozyme-Augmented Photoacoustic Nanoprobe for Early Diagnosis and Therapy of Acute Liver Failure, Advanced Materials, 2022, 34, 2108348.\r
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Fan Xia,# Xi Hu,# Bo Zhang,# Xun Wang,# Yunan Guan, Peihua Lin, Zhiyuan Ma, Jianpeng Sheng, Daishun Ling*, Fangyuan Li*, Ultrasmall Ruthenium Nanoparticles with Boosted Antioxidant Activity Upregulate Regulatory T Cells for Highly Efficient Liver Injury Therapy, Small, 2022, 18, 2201558.\r
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Youkun Zheng#，Min Wei#，Haibin Wu，Fangyuan Li*，Daishun Ling*，Antibacterial metal nanocluster. Journal of Nanobiotechnology, 2022, 20, 328.\r
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Jiyoung Lee#, Hongwei Liao#, Qiyue Wang, Jieun Han, Jun-Hyeok Han, Ha Eun Shin, Minghua Ge, Wooram Park*, Fangyuan Li*, Exploration of nanozymes in viral diagnosis and therapy, Exploration, 2022, 2, 20210086.\r
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Yamin Liu#, Qiyue Wang#, Fangyuan Li, Daishun Ling*, Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy, Acta Pharmaceutica Sinica B, 2022, in press.\r
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Lingxiao Zhang#, Heng Sun#, Jing Zhao, Jiyoung Lee , Liang Ee Low, Linji Gong, Ying Chen, Nan Wang, Chaojie Zhu, Peihua Lin, Zeyu Liang, Min Wei, Daishun Ling, Fangyuan Li*, Dynamic nanoassemblies for imaging and therapy of neurological disorders, Advanced Drug Delivery Reviews, 2021, 175, 113832.\r
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Xi Hu#, Fangyuan Li#, Fan Xia, Qiyue Wang, Peihua Lin, Min Wei, Linji Gong, Liang Ee Low, Ji Young Lee, Daishun Ling*. Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature, Advanced Drug Delivery Reviews, 2021, 175, 113830.\r
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Lingxiao Zhang#, Heng Sun, Ying Chen, Min Wei, Jiyoung Lee, Fangyuan Li*, Daishun Ling*, Functional nano-assemblies for the diagnosis and therapy of Alzheimer’s diseases. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2021, 1696.\r
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Peihua Lin#, Mengda Cao#, Fan Xia, Hongwei Liao, Heng Sun, Qiyue Wang, Jiyoung Lee, Yan Zhou, Yunan Guan, Cheng Zhang, Zhiqiang Xu, Fangyuan Li*, Ji-Fu Wei*, Daishun Ling*. A Phosphatase-Mimetic Nano-Stabilizer of Mast Cells for Long-Term Prevention of Allergic Disease, Advanced Science, 2021, 2004115\r
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Xia Guo#, Hongwei Liao#, Jiaming Tian#, Chuang Yang, Fan Xia, Wenshi Liang, Nan Wang, Pin Li, Bo Zhang, Linji Gong, Xi Hu, Liang Zhang, Fangyuan Li*, Daishun Ling*. A Bimetallic Nanocatalyst for Light-free Oxygen Sensitization Therapy, Cell Reports Physical Science, 2021, 2, 100538.\r
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Qiyue Wang#, Zeyu Liang#, Fangyuan Li*, Jiyoung Lee, Liang Ee Low, Daishun Ling*, Dynamically Switchable Magnetic Resonance Imaging Contrast Agents, Exploration, 2021, 1, 20210009.\r
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Anran Yuan#, Fan Xia#, Qiong Bian, Haibin Wu, Yueting Gu, Tao Wang, Ruxuan Wang, Lingling Huang, Qiaoling Huang, Yuefeng Rao, Daishun Ling, Fangyuan Li*, Jianqing Gao*. Ceria Nanozymes-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment, ACS Nano, 2021, 15, 13759-13769.\r
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Sadia Nadeem#, Chuang Yang#, Yang Du#, Fangyuan Li*, Zheng Chen, Yan Zhou, Ji Young Lee, Qiang Ding*, Daishun Ling*. A Virus-Spike Tumor-Activatable Pyroptotic Agent, Small, 2021, 17, 2006599.\r
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Liang Ee Low#, Qiyue Wang#, Ying Chen, Peihua Lin, Shengfei Yang, Linji Gong, Jiyoung Lee, Sangeetaprivya P. Siva, Bey-Hing Goh, Fangyuan Li*, Daishun Ling*, Microenvironment-tailored nanoassemblies for the diagnosis and therapy of neurodegenerative diseases, Nanoscale, 2021, 13, 10197-10238.\r
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Ying Chen#, Min Wei, Jiyoung Lee, Jing Zhao, Peihua Lin, Qiyue Wang, Fangyuan Li*, Daishun Ling*, Neurodegenerative Disease Diagnosis via Ion Level Detection in the Brain, Advanced NanoBiomed Research, 2021, 2100007.\r
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Min Wei#, Jiyoung Lee#, Fan Xia, Peihua Lin, Xi Hu, Fangyuan Li*, Daishun Ling*, Chemical Design of Nanozymes for Biomedical Applications, Acta Biomaterialia, 2021, 126,15-30.