个人简历

陈家东，浙江大学基础医学院研究员，博士生导师。2004年于南京大学基础学科教学强化部（现匡亚明学院）获得学士学位，2010年于中国科学院上海神经科学研究所获得神经生物学博士学位。2011年起在美国加州大学旧金山分校从事神经环路发育和神经干细胞研究。研究成果以第一作者和通讯作者发表于Science, Cell Stem Cell, Glia 等神经科学和干细胞科学领域顶级杂志。获得美国CARE & CURE 儿童癫痫研究博士后奖学金和美国癫痫研究协会青年项目基金。

研究领域

结合单细胞测序、电生理、透明脑、在体光遗传学等手段研究大脑抑制性神经环路的细胞多样性、细胞特异性的脑连接图谱和环路功能。""

近期论文

1. Chen J†, KriegsteinAR†. (2015) A GABAergic projection from the zona incerta to cortex promotes cortical neuron development. Science. Oct 30;350(6260):554- 8. († Co-correspondence author) Subject of Previews “Neurotransmitter-tailored dendritic trees” \r
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2. Pollen AA, Nowakowski TJ, Chen J, Retallack H, Sandoval-Espinosa C, Nicholas CR, Shuga J, Liu J, Oldham MC, Diaz A, Leyrat AA, West JA, Kriegstein AR. (2015) Molecular Identity of Human Outer Radial Glia During Cortical Development. Cell. Sep 24;163(1):55-67. \r
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3. Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A. (2014) Axonal Control of the Adult Neural Stem Cell Niche. Cell Stem Cell. Apr 3;14(4):500-11. (Featured Article) \r
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4. Nicholas CR*, Chen J*, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. (2013). Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell stem cell. May 2;12(5):573-86. (* Co-first author) Subject of Previews “Human cortical interneurons take their time” \r
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5. Chen J*, Tan Z*, Zeng L, Zhang X, He Y, Gao W, Wu X, Li Y, Bu B, Wang W, Duan S. (2013). Heterosynaptic long-term depression mediated by ATP released from astrocytes. Glia. Feb;61(2):178-91. (* Co-first author)