研究领域

抗帕金森病创新药物研制及作用机制的研究。

近期论文

1. Yang Heng, Qiu-Shuang Zhang, Zheng Mu, Jin-Feng Hu, Yu-He Yuan*, Nai-Hong Chen* Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra, Toxicol Lett, 2016; 243:7-21
2. Yuan YH, Yan WF, Sun JD, Huang JY, Mu Z, Chen NH*.The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway. Toxicol Lett, 2015; 233: 163-171.
3. Yuan YH, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH*.Rotenone could activate microglia through NFκB associated pathway. Neurochem Res. 2013;38:1553-60
4. Yan WF, Shao QH, Zhang DM, Yuan YH*, Chen NH*. The molecular mechanism of polygalasaponin F-mediated decreases in TNF α: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res, 2015; 17: 662-670.
5. Wu MM, Yuan YH, Chen J, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J Asian Nat Prod Res 2014; 16:59-69. (共同第一）
6. Wei W, Yuan YH, Gao YN, Yan WF, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-kappaB pathway regulation. J Asian Nat Prod Res 2014; 16:865-875.(共同第一）
7. Yuan Y, Sun J, Zhao M, Hu J, Wang X, Du G, Chen NH*. Overexpression of alpha-synuclein down-regulates BDNF expression. Cell Mol Neurobiol. 2010;30:939-46.
8. 闫文芬, 衡洋，邵千航，陈乃宏，苑玉和*. 建立以α-突触核蛋白损伤为靶点的细胞筛选模型. 中国药理学通报, 2015; 31: 586 -590.
9. 闫文芬, 陈乃宏，苑玉和*.α-突触核蛋白与Cu2+ 相互作用的研究进展.中国药理学通报, 2015; 31: 7-10.
10.苑玉和，吴苗苗，刘岩，胡金凤，王宏旭，陈乃宏*，建立NF-kB核转位的转基因细胞模型，药理学通报，2012;28: 726-728