个人简历
1984年毕业于河南中医学院（现河南中医药大学），医学学士。1999年毕业于郑州大学化学系有机化学专业，有机化学博士。1984年－1999年在河南化学研究所从事天然药物化学及有机合成化学研究，任研究实习员、助理研究员。1999年－2001年在中国药科大学从事博士后研究，任助理研究员。2001年9月至今在中国医学科学院/北京协和医学院药物研究所天然药物化学研究室工作，先后任副研究员、研究员、博士生导师。
研究领域
(1) 靶向x-盒结合蛋白-1(XBP1)激动剂及抑制剂的合成和构效关系研究；(2) 以XBP1为靶点的创新药物研究。"药物化学研究：活性天然产物的合成和成药性导向的结构多样性修饰研究。"
近期论文
1. Meng Xie, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hui Zhang, Zhi-Hong Li, Wen-Jie Wang, and Hai-Lin Qin*. Synthesis and structure-sctivity relationships of N-dihydrocoptisine-8-ylidene aromatic amines and N-dihydrocoptisine-8-ylidene aliphatic amides as anti-ulcerative colitis agents targeting XBP1. Journal of Natural Products. 2016, 79, 775-783. DOI: 10.1021/acs.jnatprod.5b00807.2. Zhi-Hui Zhang, Jing Li, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hong Li, Hong-Rui Song, Wen-Jie Wang, Hai-Lin Qin*. Versatile methods for synthesizing organic acid salts of quaternary berberine-type alkaloids as anti-ulcerative colitis agents, J. Asian Nat. Prod. Res, 2016, 18, DOI: 10.1080/10286020.2016.1171760.3. Dan Zhang, An-Jun Deng, Lin Ma, Xue-Fu You, Zhi-Hui Zhang, Zhi-Hong Li, Jian-Dong Jiang, Hai-Lin Qin. N-Substituted acetamide glycosides from the stems of Ephedra sinica, Phytochemistry Letters, 2015, 12, 320-327.4. Zhi-Hui Zhang, Hai-Jing Zhang, An-Jun Deng, Bo Wang, Zhi-Hong Li, Yang Liu, Lian-Qiu Wu, Wen-Jie Wang, and Hai-Lin Qin. Synthesis and structure-activity relationships of quaternary coptisine derivatives as potential anti-ulcerative colitis agents. Journal of Medicinal Chemistry. 2015, 58, 7557-7571.5. Jin Ren, Yan-Gai Wang, Ai-Guo Wang, Lian-Qiu Wu, Hai-Jing Zhang, Wen-Jie Wang, Ya-Lun Su, and Hai-Lin Qin. Cembranoids from the gum resin of Boswellia carterii as potential anti-ulcerative colitis agents. Journal of Natural Products. 2015, 78, 2322-2331.6. Zhi-Hui Zhang, An-Jun Deng, Lian-Qiu Wu, Lian-Hua Fang, Jin-Qian Yu, Zhi-Hong Li, Tian-Yi Yuan, Wen-Jie Wang, Guan-Hua Du, Hai-Lin Qin*. Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives, European Journal of Medicinal Chemistry, 2014, 86, 542-549.7. Zhi-Hui Zhang, Lian-Qiu Wu, An-Jun Deng, Jin-Qian Yu, Zhi-Hong Li, Hai-Jing Zhang, Weng-Jie Wang, Hai-Lin Qin*. New synthetic method of 8-oxocoptisine starting from natural quaternary coptisine as anti-ulcerative colitis agent, J. Asian Nat. Prod. Res, 2014, 16(8), 841-846.8. Yong Yu, An-Jun Deng, Zhi-Hong Li, Ai-Lin Liu, Lin Ma, Zhi-Hui Zhang, Xiu-Li Wang, Gu-Hua Du, Hai-Lin Qin*. New Stemona alkaloids from the roots of Stemona tuberose, Magn. Reson. Chem. 2014, 52, 719-728.9. Jin-Qian Yu, An-Jun Deng, Hai-Lin Qin*. Distinctive features of chemical composition from Bupleurum chinense applicable to original authentication, Anal. Methods, 2014,6, 1067-1075.10. Hai-Yan Zhang, Tian-Zeng Zhao*, Jian-Jun Dong, Rong-Feng Chen, Zhi-Hong Li, Hailin Qin*. Four new sesquiterpene polyol esters from Celastrus angulatus, Phytochemistry Letters, 2014, 7, 101-106.11. Jin-Qian Yu, An-Jun Deng, Lian-Qiu Wu, Zhi-Hui Zhang, Yang Liu, Wen-Jie Wang, Hai-Lin Qin*. Osteoclast-inhibiting saikosaponin Dderivertives from Bupleurum chinense, Fitoterapia, 2013,85, 101-108.12. Jin-Qian Yu, An-Jun Deng, Hai-Lin Qin*. Nine new steroidal glycosides from the roots of Cynanchum stauntonii, Steroids, 2013,78(1):79-90.13. Qiong Zhou, An-Jun Deng, Hai-Lin Qin*. Two new quaternary protoberberine alkaloids from Corydalis yanhusuo, J. Asian Nat. Prod. Res., 2012，14（5）：476-481.14. Bo Liu, An-Jun Deng, Jin-Qian Yu, Ai-Lin Liu, Guan-Hua Du, Hai-Lin Qin*. Chemical constituents of the whole plants of Elsholtzia rugulosa, J. Asian Nat. Prod. Res.,2012，14（2）：89-96.15. Shi-Hui Shu, An-Jun Deng, Zhi-Hong Li, Hai-Lin Qin*. Bioactive biphenyl dimers from the heartwood of Caesalpinia sappan, Fitoterapia, 2011, 82, 762-766.16. Anjun Deng, Hailin Qin*. Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa. Phytochemistry，2010, 71(7) : 815-821.17. Jian-Long Sun, An-Jun Deng, Yan Li, Zhi-Hong Li, Hui Chen, and Hai-Lin Qin.* First example of diterpenoids from 14,15-cyclopimarane in the roots of Linum usitatissimum Helvitica Chimica Acta, 2009, 92 (12): 2746-2753.18. Dongmin Su, Jinglan Han, Shishan Yu, Hailin Qin*. Assessment of 1HNMR spectroscopy for specific metabolite fingerprinting of Angelica sinensis. Natural Product Communications，2008，3(5):727-730.19. Peng Wang, Ai-Lin Liu, Zheng An, Zhi-Hong Li, Guan-Hua Du, Hai-Lin Qin*. Novel alkaloids from the roots of Stemona sessilifolia, Chemistry & Biodiversity, 2007, 4(3): 523-530.20. Jun-Rong Yang, Zheng An, Zhi-Hong Li, Song Jing, Hai-Lin Qin*. Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima, Chem. Pharm. Bull., 2006,56(11): 1595-1598.
