个人简历

1996年获上海医科大学病理专业硕士学位；1998年-2001年师从中国科学院上海药物研究所丁健院士，获肿瘤药理博士学位，攻读博士学位期间主要研究沙尔威辛体内抗肿瘤作用和抗转移作用；2002年赴芬兰赫尔辛基大学做访问学者，研究植物来源的化合物对间质基质金属蛋白酶的抑制作用。

研究领域

一是针对肿瘤的发生发展及转移进行相关机制研究，着眼于肿瘤微环境在肿瘤转移中的作用研究，并在此基础上开展高通量药物筛选工作，发现可用于进一步开发的先导化合物或药物候选物，为新药发现提供物质基础；二是抗肿瘤药物评价，与国内外多家知名企业合作，进行抗肿瘤药物研发

近期论文

(1) Gao M, Li X, Dong W, Jin R, Ma H, Yang P, Hu M, Li Y, Hao Y, Yuan S, Huang J, Song L.Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation.Nucleic Acids Res. 2013 Apr 5. [Epub ahead of print]
(2)Sun L, Liu Y, Lin S, Shang J, Liu J, Li J, Yuan S, Zhang L.Early growth response gene-1 and hypoxia-inducible factor-1α affect tumor metastasis via regulation of tissue factor. Acta Oncol. 2013 May;52(4):842-51.
(3)Zhao R, Sun L, Lin S, Bai X, Yu B, Yuan S, Zhang L.The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi-targeting activity.Oncol Rep. 2013 Apr;29(4):1379-86.
(4)Dong W, Li Y, Li X, Hu M, Aodengqimuge, Sun L, Guo N, Yuan S, Song L.p85α mediates NFAT3-dependent VEGF induction in the cellular UVB response.J Cell Sci. 2013 Mar 15;126(Pt 6):1317-22.
(5) Fang D, Sun L, Lin S, Zhou L, Su N, Yuan S, Yu B.Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion. Exp Biol Med (Maywood). 2012 Sep 1;237(9):1045-55.
(6). Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, Chen L, Liu J, Shi W, Zhang L, Yuan S.BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012 Mar 31;31:313.
(7)Lin S, Wan S, Sun L, Hu J, Fang D, Zhao R, Yuan S, Zhang L.Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci. 2012 May;103(5):904-12.
(8). Koumtebarye E, Su N, Hu WF, Lin SS, Sun L,Yuan ST. Antitumor activity of Xiaoaiping injection on human gastric cancer SGC-7901 cells Chinese Journal of Natural Medicines 2012, 10(5): 339-346
(9) Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J, Liu J, Chen L, Shi W, Yuan S*, Zhu D Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitro by topotecan. Medical Oncology. DOI: 10.1007/s12032-010-9710-1. (2011).
(10) Li Sun, Sensen Lin, Renping Zhao, Boyang Yu, Shengtao Yuan*, and Luyong Zhang. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol. Pharm. Bull. 33(7) 1192-1198 (2010).
(11) SUN Li, LIN Sen-Sen, Yu Bo-Yang, YUAN Sheng-Tao*, ZHANG Lu-Yong.High-throughput screening model for tissue factor inhibitor and effect of DT-13 on anti-tumor metastasis. Chin J Nat Med. Nov. 2010 Vol. 8 No. 6 466-470.
(12) Sensen Lin, Li Sun, Jialiang Hu, Shuying Wan, Renping Zhao, Shengtao Yuan*, Luyong Zhang. Chemokine CXC motif receptor 6 contributes to cell migration during hypoxia ，Cancer Lett. 2009 Jun 28; 279(1):108-17.
(13) Sen-sen LIN, Li SUN, Yan-kai ZHANG, Ren-ping ZHAO, Wen-lu LIANG, Sheng-tao YUAN*, Lu-yong ZHANG. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases, Acta Pharmacologica Sinica. 2009 May; 30(5):628-36.