个人简历

温小安，博士，副研究员，现任职于中国药科大学药物科学研究院新药研究中心（江苏省代谢性疾病药物重点实验室），主要从事代谢性疾病药物和抗肿瘤药物分子设计与合成相关研究。1998年、2007年分别获中国药科大学化学制药专业工学学士学位、药物化学专业理学博士学位。2010～2012年获法中科学及应用基金会（FFCSA）和国家留学基金委联合资助，在法国里尔第二大学生物结构与药物发现研究中心（INSERM U761）从事博士后研究工作。1998～2002年曾在江苏豪森药业股份有限公司从事新药研发工作，2007年进入中国药科大学新药研究中心工作至今。主持国家自然科学基金(面上项目：No.81473080，青年项目：No.21002125)、江苏省自然科学基金（面上项目：BK20141355）、教育部高等学校博士点专项基金（No.20090096120009）等资助课题，参与国家科技重大专项、高等学校科技创新工程重大项目培育资金等资助项目的研究工作

研究领域

代谢性疾病药物研究

近期论文

1.Zeng-Wei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin. European Journal of Medicinal Chemistry 2014, 83, 547–560.
2.Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen*, Hongbin Sun*. Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry 2014, 22, 1383–1393.
3.Xiaowei Sun, Chengzhe Gao, Fan Zhang, Zhuang Song, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Electronic and steric effects on the intramolecular Schmidt reaction of alkyl azides with secondary benzyl alcohols. Tetrahedron 2014,70, 643–649
4.Dongyin Chen, Chang Xu, Jie Deng, Chunhuan Jiang, Xiaoan Wen, Lingyi Kong, Ji Zhang*, Hongbin Sun*. Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers. Tetrahedron 2014, 70, 1975–1983.
5.Liying Zhang, Xiaojian Jia, Jizhe Dong, Dongyin Chen, Jun Liu*, Luyong Zhang, Xiaoan Wen*. Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents. Chemical Biology & Drug Design 2014, 83, 297–305.
6.Jiao Hao, Jun Liu, Xiaoan Wen.Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2074-2077.*, Hongbin Sun*.
7.Ben Niu, Xiaoan Wen, Zhijun Jia, Xiaoming Wu, Wanhua Guo*, Hongbin Sun*. Synthesis and preliminary evaluation of 1-[18F]fluoro-1-deoxy-2,5-anhydro-D-mannitol as a PET radiotracer for breast cancer imaging. Chinese Journal of Chemistry 2013, 31, 1159-1163.
8.宋洁梅, 温小安, 孙宏斌*. 抗肿瘤新靶点USP7 及其抑制剂的研究进展. 中 国 药 物 化 学 杂 志, 2013, 23 (6), 486–492.
9.宋洁梅, 温小安, 孙宏斌*. 肺动脉高压发生机制及治疗药物的研究进展. 中国药科大学学报2013, 44, 1-10.
10. Xiaoan Wen, Jamal El Bakali, Rebecca Deprez-Poulain, Benoit Deprez. Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles. Tetrahedron Letters 2012, 53, 2440-2443.
11. Zhongjie Liang, Liying Zhang, Lianchun Li, Jun Liu, Hongling Li, Luyong Zhang, Limin Chen, Keguang Cheng, Mingyue Zheng, Xiaoan Wen, Pu Zhang, Jia Hao, Yanchun Gong, Xia Zhang, Xiaoyun Zhu, Jun Chen, Hong Liu, Hualiang Jiang, Cheng Luo*, Hongbin Sun b*. Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies, European Journal of Medicinal Chemistry2011, 46, 2011-2021.
12.Xiaoan Wen, Jun Liu, Luyong Zhang, Peizhou Ni, Hongbin Sun*. Synthesis and biological evaluation of arjunolic acid, bayogenin, hederagonic acid and 4-epi-hederagonic acid as glycogen phosphorylase inhibitors. Chinese Journal of Natural Medicines 2010, 8, 441-448.
13.温小安, 张迎霞, 柳 军, 张陆勇, 倪沛洲, 孙宏斌*。杂环并五环三萜化合物的合成及糖原磷酸化酶抑制活性，中国药科大学学报 2009，40，491-496.
14.Xiaoan Wen, Hongbin Sun*, Jun Liu, Keguang Cheng, Pu Zhang, Liying Zhang, Jia Hao, Luyong Zhang, Peizhou Ni, Spyros E. Zographos, Demetres D. Leonidas, Kyra-Melinda Alexacou, Thanasis Gimisis, Joseph M. Hayes, Nikos G. Oikonomakos*. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Journal of Medicinal Chemistry2008, 51, 3540-3554.
15.Jia Hao, Pu Zhang, Xiaoan Wen, Hongbin Sun*. Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. Journal of Organic Chemistry 2008, 73, 7405-7408.
16.Xiaoan Wen, Jun Xia, Keguang Cheng, Liying Zhang, Pu Zhang, Jun Liu, Luyong Zhang, Peizhou Ni and Hongbin Sun*. Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Bioorganic & Medicinal Chemistry Letters 2007, 17, 5777-5782.
17.Xiaoan Wen, Pu Zhang, Jun Liu, Luyong Zhang, Xiaoming Wu, Peizhou Ni and Hongbin Sun*. Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors. Bioorganic & Medicinal Chemistry Letters 2006, 16, 722-726.
18.Xiaoan Wen, Hongbin Sun*, Jun Liu, Guanzhong Wu, Luyong Zhang, Xiaoming Wu, Peizhou Ni.Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorganic & Medicinal Chemistry Letters 2005, 15, 4944-4948.
19.孙宏斌, 温小安. 一种丁苯那嗪的制备方法, 中国专利（授权）: ZL201010017288.5.