个人简历

1994年，获药物分析专业学士学位，1997年获药物分析学硕士学位，研究方向为光谱分析，2004年获药物分析学博士学位，研究方向为色谱分析。2014年9月-2015年9月至美国University of Maryland School of Medicine, Institute of Human Virology访问，从事多肽、蛋白质药物研究。1997年任中国药科大学药物分析教研室助教，2000年任中国药科大学药物分析教研室讲师，2007年任中国药科大学药物分析学副教授，2013年任中国药科大学药物分析学教授。江苏省高校“青蓝工程”中青年学术带头人，江苏省 “333工程”第三层次培养对象。中国药学会药物分析专业委员会委员，中国药科大学学术委员会委员。药物分析杂志编委，中国药科大学学报编委，中国现代应用药学杂志编委。近5年，主持国家自然基金面上项目2项，国家十二五新药创制重大专项，科技支疆项目，江苏省自然科学基金面上项目和新疆维吾尔自治区自然科学基金面上项目，参与其他纵向研究6项，与企业签订合同20余项。获上海市科技进步二等奖，上海药学科技三等奖，中华中医药学会科学技术奖三等奖，2014年江苏省优秀硕士论文指导教师。2011-2015年，累计发表论文50余篇，授权中国发明专利4篇。药物分析江苏省优秀教学团队主要成员，主编药物分析实验双语十一五规划教材，参编人卫版《药物分析》国家十二五规划教材，参编其他药物分析相关教材及专著8本。药物分析国家精品课程、国家双语示范课程、国家网络资源课程核心成员。获国家教学成果二等奖1项，江苏省教学成果特等奖1项，江苏省教学成果二等奖1项。

研究领域

""药物分析新材料与新技术""""

近期论文

Cuicui Li,Ni Zhao,Luyan An,Zhen Dai,Xiaoyi Chen,Fan Yang,Qidong You,Bin Di*,Chi Hu*,Lili Xu*.Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRAS(G12C)[J]. Acta Pharmaceutica Sinica B,2021,(09):2670-2684.\r
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Zhen Dai, Xiao-yi Chen, Lu-yan An, Cui-cui Li, Ni Zhao, Fan Yang, Song-tao You, Chen-zhi Hou, Kan Li, Cheng Jiang,* Qi-dong You,* Bin Di,* and Li-li Xu*. Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis. J. Med. Chem. 2021, 64, 871−889.\r
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Advances in Cryochemistry: Mechanisms, Reactions and Applications. Lu-Yan An, Zhen Dai, Bin Di* and Li-Li Xu*. Molecules 2021, 26, 750.\r
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Chenzhi Hou , Tingting Chu , Mengyi Chen , Zhendong Hua, Peng Xu, Hui Xu, Youmei Wang, Jun Liao, Bin Di⁎. Application of multi-parameter population model based on endogenous population biomarkers and flow volume in wastewater epidemiology Science of the Total Environment 759 (2021) 143480\r
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Chenzhi Hou,Zhendong Hua,Peng Xu,Hui Xu,Youmei Wang,Jun Liao,Bin Di*.Estimating the prevalence of hepatitis B by wastewater-based epidemiology in 19 cities in China [J]. Science of the Total Environment, 2020, 740 :139696.\r
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Kan Li,Jing-jing Li,Ni Zhao,Bin Di,Ying Ma,Li-li Xu.Synthesis, crystal structures and properties of five novel coordination polymers and application in removing heavy metals from water[J]. Inorganica Chimica Acta, 2020, 507:119598.\r
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Kan Li,Jing-jing Li,Ni Zhao,Ying Ma,Bin Di.Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF[J]. Molecules,2020,25(6):1312.\r
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Ni Zhao,Cui-cui Li,Bin Di,Li-li Xu.Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors[J]. Journal of Autoimmunity,2020,113(113): 102515.\r
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Li-Li Xu,Yu-Feng Wu,Fang Yan,Cui-Cui Li,Zhen Dai,Qi-Dong You,Zheng-Yu Jiang,Bin Di.5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress[J]. Free Radical Biology and Medicine,2019,134(134): 288-303.\r
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Da-Song Yang; Yin-He Yang; Yunjiang Zhou; Li-Li Yu; Rui-Han Wang; Bin Di(*); Miao-Miao Niu*; A Redox-Triggered Bispecific Supramolecular Nanomedicine Based on Peptide Self-Assembly for High-Efficacy and Low-Toxic Cancer Therapy. Advanced Functional Materials, 2019-10-30 , 1904969.\r
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Li-li Xu;Cui-cui Li; Lu-yan An; Zhen Dai; Xiao-yi Chen; Qi-dong You*; Chi Hu*; Bin Di(*); Selective apoptosis-inducing activity of synthetic hydrocarbon-stapled SOS1 helix with D-amino acids in H358 cancer cells expressing KRASG12C, European Journal of Medicinal Chemistry, 2019-11-2 , 185.\r
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Jing Jia; Huilin Wen; Sibo Zhao; Lancheng Wang; Haishi Qiao; Haowen Shen; Ziyi Yu; Bin Di(*); Lili Xu*; Chi Hu*; Displacement Induced Off−On Fluorescent Biosensor Targeting IDO1 Activity in Live Cells, Analytical Chemistry, 2019-11-12 , 91：14943-14950.\r
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Haishi Qiao; Jing Jia; Haowen Shen;Sibo Zhao;Enping Chen;Wei Chen*; Bin Di(*); Chi Hu*; Capping Silica Nanoparticles with Tryptophan-Mediated Cucurbit[8]uril Complex for Targeted Intracellular Drug Delivery Triggered by Tumor-Overexpressed IDO1 Enzyme, Advanced Healthcare Materials, 2019-4-16 , 1900174.\r
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Kan Li; Da-Song Yang; Xiao-Fei Gu*; Bin Di(*); Absolute configuration determination of asarinin by synchrotron radiation with crystalline sponge method, Fitoterapia, 2019-2-13 , 134 ：135- 140.\r
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Kan Li; Jing-jing Li; Ni Zhao; Ting-ting Xie; Bin Di(*); Li-li Xu*; Thioether-based recyclable metal–organic frameworks for selective and efficient removal of Hg2+ from water, Dalton Transactions, 2019-11- 19 , 48：17800-17809.\r
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Yin-He Yang; Bin Di(*); Da-Song Yang*; The discovery of a freezinginduced peptide ligation during the total chemical synthesis of human interferon-ε, Organic & Biomolecular Chemistry, 2018-6-25 , 16：5097- 5101..\r
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Luan Jiaqi; Feng Rui; Yu Chen; Wu Xuri; Shen Wenbin; Chen Yijun; Di Bin(*); Su Mengxiang*; Quantitative assessment of the absolute purity of thiopeptcin reference standard by 1H-NMR, ANALYTICAL SCIENCES, 2018-9-10 , 34(9)：1093-1098.\r
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Tong-yuan Lin, Hong-ping Min, Cheng Jiang, Miao-miao Niu, Fang Yan, Li-li Xu*, Bin Di*. Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-Box Domain inhibitors. Bioorganic & Medicinal Chemistry, 2018, DOI: 10.1016/j.bmc.2018.05.014.\r
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Chen Yu, Qian Zhang, Peng‐yao Xu, Yin Bai, Wen‐bin Shen, Bin Di*, Meng‐xiang Su*. Quantitative determination and validation of octreotide acetate using 1H‐NMR spectroscopy with internal standard method. Magnetic Resonance in Chemistry, 2018, 56(1):37-45.\r
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Lucas Phil, Muhammad Naveed, Imran Shair Mohammad, Li Bo*, Di Bin*. Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products. Biomedicine & Pharmacotherapy, 2018, 102, 438-451.