个人简历

1992年中国药科大学药物代谢动力学专业硕士毕业后留校任教，历任助教，讲师和副教授，2001年获药动学与生物药剂学专业博士学位，2002年至2003年作为访问学者于日本近畿大学生物药剂学实验室从事药代动力学领域的合作研究，2007年被评为教授，2008年晋升为博士生导师。

研究领域

1、药物代谢动力学研究
2、生物大分子药物的药动学与生物药剂学研究

近期论文

1.Yang S, Talbi A, Wang X, Song H, Chen X*.Pharmacokinetics study of calf thymus DNA in rats and beagle dogs with 3H-labeling and tracing method.J Pharm Biomed Anal. 2014;88(1):60-65.
2.Qiu Z, Li N, Song L, Lu Y, Jing J, Parekha HS, Gao W, Tian F, Wang X, Ren S, Chen X*. Contributions of Intestine and Plasma to the Presystemic Bioconversion of Vicagrel, an Acetate of Clopidogrel.. Pharm Res. 2014 Jan;31(1):238-51
3.Zhao D, Zhang Y, Wang Y, Xu C, Dong C, Li C, Ren S, Zhang W, Lu Y, Dai Y, Chen X*.Pharmacokinetics study of hemin in rats by applying 58Fe-extrinsically labeling techniques in combination with ICP-MS method. J Pharm Biomed Anal,2014 Jan;88:331-6
4.Li N, Qiu Z, Wang X, Li T, Ji H, Zhang Y, Lu Y, Zhao D, Chen X*. Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor. Xenobiotica. 2014 Jan;44(1):59-69.
5.Yang SY, Zheng Y, Chen JY, Zhang QY, Zhao D, Han DE, Chen XJ*. Comprehensive study of cationic liposomes composed of DC-Chol and cholesterol with different mole ratios for genetransfection. Colloids Surf B Biointerfaces. 2013,101(1):6-13.
6.Qiu Z, Li N, Wang X, Tian F, Liu Q, Song L, Fan Z, Lu Y, Chen X*. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs. J Pharm Sci. 2013, 102(2):741-9.
7.Zhang Y, Zhao D, Xu J, Xu C, Dong C, Liu Q, Deng S, Zhao J, Zhang W, Chen X*. Effects of Dietary Factors on the Pharmacokinetics of (58)Fe-labeled Hemin After Oral Administration in Normal Rats and the Iron-deficient Rats. Biol Trace Elem Res. 2013,153(1-3):243-50.
8.Wang X, Song L, Li N, Qiu Z, Zhou S, Li C, Zhao J, Song H, Chen X*. Pharmacokinetics and biodistribution study of Paclitaxel liposome in sprague-dawley rats and beagle dogs by liquid chromatography-tandem mass spectrometry. Drug Res (Stuttg). 2013,63(11):603-6.
9.Zhao D, Zhang Y, Xu C, Dong C, Lin H, Zhang L, Li C, Ren S, Wang X, Yang S, Han D, Chen X. Pharmacokinetics, tissue distribution, and plasma protein binding study of platinum originating from dicycloplatin, a novel antitumor supramolecule, in rats and dogs by ICP-MS.Biol Trace Elem Res. 2012 Aug;148(2):203-8
10.Zhao D, Gao ZD, Han DE, Li N, Zhang YJ, Lu Y, Li TT, Chen XJ. Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx.Phytother Res. (2012) Phytother Res. 2012 Jan;26(1):118-21
11.Shuoye Yang, Qiuyang Zhang, Jiayin Chen, Deen Han, Di Zhao, Xijing Chen. Pharmacokinetics and disposition study of calf thymus DNA in rats by applying 3H-labelling method.Journal of Pharmaceutical and Biomedical Analysis. 2012, 64-65: 35-39.
12.Yang S, Chen J, Zhao D, Han D, Chen X. Comparative study on preparative methods of DC-Chol/DOPE liposomes and formulation optimization by determinating encapsulation efficiency.Int J Pharm. 2012 Sep 15;434 (1-2) :155-60
13.Han DE, Zheng Y, Chen X, He J, Zhao D, Yang S, Zhang C, Yang Z. Identification and Characterization of Human UDP-Glucuronosyltransferases Responsible for the In Vitro Glucuronidation of Salvianolic acid A.Drug Metab Pharmacokinet. 2012 Dec 25;27(6):579-85.
14.Zhang L, Li N, Lai Y, Zhang Y, Chen X, Chen L, Ji H, Li C. Pharmacokinetic, distribution, metabolism, and excretion of (Z)-2-amino-1,5 -dihydro-1-methyl-5- [4-(mesyl)benzylidene]-4H- imidazol-4-one mesilate (ZLJ-601) in Sprague-Dawley rats.Phytother Res. 2012 Jan;26(1):118-21
15.Fang F, Lu Y, Liang Y, Zhu J, He J, Zheng J, Li N, Tang Y, Zhu J, Chen X. Evaluation of insulin lispro and biosynthetic human insulin in pulmonary absorption: in vivo and in vitro studies.Pharmazie. 2012 Aug;67(8):706-11.
16.Zheng J, Zheng Y, Chen J, Fang F, He J, Li N, Tang Y, Zhu J, Chen X. Enhanced pulmonary absorption of recombinant human insulin by pulmonary surfactant and phospholipid hexadecanol tyloxapol through Calu-3 monolayers. Pharmazie. 2012 May;67(5):448-51.
17.Bing Yang, Yang Lu, Jianheng Zheng, Jing Zhu, Jiake He, Di Zhao, Pengfei Song and Xijing Chen. Pharmacokinetics of the prodrug thiamphenicol glycinate and its active parent compound thiamphenicol in beagle dogs following intravenous administration. Xenobiotica. 2011, 41(3): 226-31
18.Jiake He, Zhixia Qiu, Ning Li, Yang Yu, Yang Lu, Deen Han, Tingting Li, Di Zhao, Wei Sun, Fang Fang, Jianheng Zheng, Hongwei Fan and Xijing Chen. Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. European Journal of Clinical Pharmacology. 2011, 67(7): 701-707
19.Tingting Li, Yi Zheng, Feifei Fu, Hui Ji, Xijing Chen, Ying Zhao, Di Zhao, Ning Li, Lingli Zhang. Assessment of UDP-glucuronosyltransferase catalyzed formation of picroside II glucuronide in microsomes of different species and recombinant UGTs. Xenobiotica. 2011, 47:530-537
20.Tingting Li, Qiaoling Yu, Deen Han, Ying Zhao, Di Zhao, Hui Ji, Xijing Chen，Ning Li, Zhixia Qiu, Yi Zheng. Structure elucidation of metabolites of picroside II in rat bile by LC-ESI-IT-MS. Chromatographia. 2011, 73:1111–1120