个人简历

现任药学院副院长、中国医科大学-贝尔法斯特女王大学联合学院副院长、药学院神经内分泌药理研究室主任。
湖北中医药大学讲座教授。
1991到2013年，在美国著名的梅奥医学中心（Mayo Clinic）任助理教授，高级研究员，从事胃肠动力学，胰腺分泌的神经调控机制与相关疾病及药物研究。获美国胃肠动力协会（The American Motility Sociaty）2002年卓越青年科学研究奖。主导和参与美国Rhythm药物研发基金，美国NIH基金DK17638，DK17632，DK52766, DK57061的科研工作，合作完成瑞典医学会与瑞典糖尿病协会项目72X-14NNN的科研工作。主持国家自然科学基金一项。

研究领域

胰腺神经系统对胰岛分泌调控，胃肠动力学及相关疾病的机理与药物治疗""

近期论文

1. Mingyan Liu, Fujun Chen, Lei Sha, Shuang Wang, Lin Tao, Lutian Yao, Miao He, Zhimin Yao, Hang Liu, Zheng Zhu, Zhenjie Zhang, Zhihong Zheng, Xianzheng Sha, Minjie Wei (-)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75(NTR) Signaling in APP/PS1 Transgenic Mice. Molecular Neurobiology. 12/2013 Pub-Med pre-publication。
2. Sha L, Linden DR, Farrugia G, Szurszewski JH. Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle. J Physiol. 2014 Mar 1;592(Pt 5):1077-89
3. Sha L, Linden DR, Farrugia G, Szurszewski JH. Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion. J Neurosci. 2013 Jul 31;33(31):12638-46.
4. Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G. Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5. Am J Physiol: GI, 2011 300(6):G1105-14.
5. Sha, L., Farrugia G, Linden DR, Szurszewski JH. The Transwall Gradient Across the Mouse Colonic Circular Muscle Layer is Carbon Monoxide-Dependent. FASEB J. 24(10):3840-9. 2010
6. Tharayil VS, Wouters MM, Stanich JE, Roeder JL, Sha L, Beyder A, Gomez-Pinilla PJ, Gershon MD, Maroteaux L, Gibbons SJ, Farrugia G. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. NeurogastroenterolMotil. 2010 Apr;22(4):462-9
7. Strege PR, Sha L, Beyder A, Bernard CE, Perez-Reyes E, Evangelista S, Gibbons SJ, Szurszewski JH, Farrugia G.. T-type Ca(2+) channel modulation by otilonium bromide. Am J PhysiolGastrointest Liver Physiol. 298(5):G706-13 2010
8. Gibbons SJ, Strege PR, Sha L, Roeder JL, Mazzone A, Ou Y, Rich A, Farrugia G. The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4422-31.
9. Wouters MM, Roeder JL, Tharayil VS, Stanich JE, Strege PR, Sha L, Bardsley MR, Ordog T, Gibbons SJ, Farrugia G. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009
10. Linden DR, Sha L, Mazzone A, Stoltz GJ, Bernard CE, Furne JK, Levitt MD, Farrugia G, Szurszewski JH.. Production of the gaseous signal molecule hydrogen sulfide in mouse tissues. J Neurochem. 106(4):1577-85 2008
11. Sha L, Farrugia G, Harmsen WS, Szurszewski JH. Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine. American Journal of Physiology: Gastrointestinal and Liver Physiology 293(2):G438-G445, 2007.
12. Strege PR, Mazzone A, Kraichely RE, Sha L., Holm AN, Ou Y, Lim I, Gibbons SJ, Sarr MG, Farrugia G. Species dependent expression of intestinal smooth muscle mechanosensitive sodium channels. NeurogastroenterolMotil. 2007 Feb;19(2):135-43
13. Sha, L., Image Compression. In Encyclopedia of GIS. ShashiShekhar (Author, Editor), HuiXiong (Editor). Springer 2007.
14. Matsuda, N. M., Miller, S. M., Sha, L., Farrugia G, Szurszewski JH. Mediators of non-adrenergic non-cholinergic inhibitory neurotransmission in porcine jejunum. Neurogastroenterology and Motility 16(5):605-612, 2004.
15. Vernino, S., Ermilov, L. G., Sha, L., Szurszewski JH, Low PA and Lennon VA. Passive transfer of autoimmune autonomic neuropathy to mice. Journal of Neuroscience 11:24(32):7037-42, 2004.
16. Sha, L., Miller SM, Szurszewski JH. Morphology and electrophysiology of neurons in dog paraventricular nucleus: in vitro study. Brain Research, 1010:95-107, 2004.
17. Strege, P. R., Ou, Y., Sha, L., Rich A, Gibbons SJ, Szurszewski JH, Sarr MG, Farrugia G. Sodium current in human intestinal interstitial cells of Cajal. American Journal of Physiology (Gastrointestinal and Liver Physiology) 285:G1111-G1128, 2003.
18. Gibbons SJ, Rich A, Distad MA, Miller SM, Schmalz PF, Szurszewski JH, Sha L, Blume-Jensen P, Farrugia G. Kit/stem cell factor receptor-induced phosphatidylinositol 3'-kinase signalling is not required for normal development and function of interstitial cells of Cajal in mouse gastrointestinal tract. NeurogastroenterolMotil. 2003 Dec;15(6):643-53
19. Farrugia, G., Sha, L., Lin X, Miller SM, Nath KA, Ferris CD, Levitt M, Szurszewski JH. A major role for carbon monoxide as an endogenous hyperpolarizing factor in the gastrointestinal tract. Proceedings of National Academy of Science 100:8567-8570, 2003.
20. Sha, L., Miller SM, Szurszewski JH. Electrophysiological effects of GABA on cat pancreatic neurons. American Journal of Physiology: Gastrointestinal and Liver Physiology 280:G324-G331, 2001.
21. Sha, L., Westerlund J, Szurszewski JH, Bergsten P. Amplitude modulation of pulsatile insulin secretion by intrapancreatic ganglion neurons. Diabetes 50 (1):51-55, 2001.
22. Sha, L., Miller SM, Szurszewski JH. Leptin modulates fast synaptic transmission in dog pancreatic ganglia. Neuroscience Letters 263:93-96, 1999.
23. Sha, L., Miller SM, Szurszewski JH. Cholinergic transmission in pancreatic ganglia of the cat. Pancreas 14:83-93, 1997.
24. Sha, L., Miller SM, Szurszewski JH. Cat pancreatic neurons: morphology, electrophysiological properties, and responses to 5 HT. Pancreas 13:111 124, 1996.
25. Sha, L., Miller SM, Szurszewski JH. Nitric oxide is a neuromodulator in cat pancreatic ganglia: histochemical and electrophysiological study. Neuroscience Letters 192:77-80, 1995.
26. Sha, L. et al：Inhibitory effects of stimulating AC, AL, BNST and AHL on visceral pain. Zhen Ci Yan Jiu 18(1):37-43, 1993.
27. Sha, L. et al：Responses of neurons in the S1 area to noxious electric stimulation of nervous peroneus communis. The study of intracellular potentials. Zhen Ci Yan Jiu 17(3):151-155, 1992.
在国际学术会议上做学术报告和论文交流：
1. Lei Sha and J. H. Szurszewski, “Effects of GABA on membrane potential of neurons in cat pancreatic ganglia,” Federation of American Societies for Experimental Biology, Experimental Biology, 1993, New Orleans, Louisiana, March 28, April 1, 1993 (论文交流).
2. Lei Sha, S. M. Miller and J. H. Szurszewski, “NADPH diaphorase activity in cat intrapancreatic ganglia,” Federation of American Societies for Experimental Biology, Experimental Biology 1993, New Orleans, Louisiana, March 28, April 1, 1993 (学术报告).
3. Lei Sha, S. M. Miller and J. H. Szurszewski, “Nitric oxide is a possible neurotransmitter in cat pancreatic ganglia,” 94th Annual Meeting of the American Gastroenterological Association, Boston, Massachusetts, May 15-21, 1993 (论文交流).
4. Lei Sha, L. L. Ou and J. H. Szurszewski, “Mediators of the S-EPSP in cat pancreatic ganglia,” Society for Neuroscience, 23rd Annual Meeting, Washington, D.C., November 7-12, 1993 (论文交流).
5. Lei Sha, S. Miller, and J. H. Szurszewski, “Nitric Oxide is a neuromodulator in cat pancreatic ganglia: Electrophysiologic study,” 95th Annual Meeting of the American Gastroenterological Association, New Orleans, Louisiana, May 15-18, 1994 (学术报告).
6. Lei Sha, S. M. Miller, S. Nitecki, and J. H. Szurszewski, “Morphology of neurons in dog paraventricular nucleus,” Federation of American Societies for Experimental Biology, Experimental Biology 95TM, Atlanta, Georgia, April 9-13, 1995 (论文交流).
7. Lei Sha, S. Nitecki, and J. H. Szurszewski, “Effects of S-CCK-OP on neurons of dog paraventricular nucleus,” 95th Annual Meeting of the American Gastroenterological Association, San Diego, California, May 14-17, 1995 (论文交流).
8. Lei Sha, S. M. Miller and J. H. Szurszewski, “Electrophysiological and morphological studies of dog paraventricular nucleus neurons,” Society for Neuroscience, 25th Annual Meeting, San Diego, California, November 11-16, 1995 (学术报告).
9. Lei Sha, S. M. Miller and J. H. Szurszewski, “Carbon monoxide synthesizing enzyme is present in pancreatic neurons of dog,” 97th Annual Meeting of the American Gastroenterological Association, Washington, D.C. May 11-14, 1997 (论文交流).
10. Lei Sha, J. Westerlund, S. M. Miller, P. Bergsten and J. H. Szurszewski, “Neural control of insulin secretion is mediated by intrapancreatic ganglia,” 97th Annual Meeting of the American Gastroenterological Association, Washington, D.C., May 11-14, 1997 (论文交流).
11. Lei Sha, S. M. Miller, and J. H. Szurszewski, “Leptin receptors are present in pancreatic ganglia,” 16th International Symposium on Gastrointestinal Motility, Lorne, Victoria, Australia, February 15-20, 1998 (论文交流).
12. Lei Sha, L. G. Ermilov, P. F. Schmalz, C-L. He, S. M. Miller and J. H. Szurszewski, “Leptin receptor-like immunoreactivity is present in rat pancreatic ganglia,” The Endocrine Society, 80th Annual Meeting, New Orleans, Louisiana, June 24-27, 1998 (论文交流).
13. Lei Sha, L. G. Ermilov, P. F. Schmalz and J. H. Szurszewski, “Localization of leptin receptor-like immunoreactivity in rat pancreatic ganglia,” 4th International Symposium on Brain-Gut Interactions, La Jolly, California, July 12-15, 1998 (论文交流).
14. Lei Sha, L. G. Ermilov, P. F. Schmalz, G. Farrugia and J. H. Szurszewski, “Leptin receptor-like immunoreactivity and NP like immunoreactivity in myenteric ganglia of the rat small intestine,” 9th European Symposium on Neurogastroenterology and Motility, Maastricht, the Netherlands, October 28-31, 1998 (学术报告).
15. Lei Sha, L. G. Ermilov, P. F. Schmalz and J. H. Szurszewski, “Distribution of leptin receptor-like immunoreactivity in rat intrapancreatic neurons,” Society for Neuroscience, 28th Annual Meeting, Los Angeles, California, November 7-12, 1998 (论文交流).
16. Lei Sha, L. G. Ermilov, P. F. Schmalz, G. Farrugia and J. H. Szurszewski, “Leptin receptor like immunoreactivity and NP like immunoreactivity in myenteric ganglia of the rat small intestine,” 9th European Symposium on Neurogastroenterology and Motility, Maastricht, The Netherlands, October 28-31, 1998 (论文交流).
17. Lei Sha, L. G. Ermilov, C.-L. He, P. F. Schmalz, G. Farrugia and J. H. Szurszewski, “Leptin receptor immunoreactivity (OB-R IR) is present in human pancreatic ganglia,” Digestive Disease Week, Orlando, FL, May 16-19, 1999 (论文交流).
18. Lei Sha, Lin, X., Miller, S. M., Ferris, C. D., Szurszewski, J. H. and Farrugia, G., “Carbon monoxide as a hyperpolarizing factor,” 12th Biennial Meeting of American Motility Society, Galveston, Texas, September 19-22, 2002 (学术报告).
19. Lei Sha, J. H. Szurszewski and G. Farrugia, “Contribution of sodium ions to the human jejunum circular smooth muscle slow wave,” Digestive Disease Week, Orlando, FL, May 17-22, 2003 (论文交流).
20. Lei Sha, G. Farrugia and J. H. Szurszewski, “NANC neuronal activity evokes slow wave like membrane depolarizations in human jejunum circular smooth muscle cells,” Digestive Disease Week, New Orleans, LA, May 15-20, 2004 (论文交流).
21. Lei Sha, A. Rich, S. Gibbons, J. Szurszewski and G. Farrugia, “Slow wave recordings from α1H T-type calcium channel knockout mice,” 13th Biennial Meeting of American Motility Society, Rochester, MN, September 9-12, 2004 (论文交流).
22. Lei Sha, Farrugia, G. and Szurszewski, J. H.: “Oxyhemoglobin abolishes the membrane potential gradient and decreases slow wave frequency in human small intestine circular muscle layer.” 14 Annual American Motility Society Scientific Meeting, San Monica, CA, September 22-25, 2005 (学术报告)
23. Lei Sha, Farrugia, G. and Szurszewski, J. H.: “Effect of NaHS on resting membrane potential of circular smooth muscle cells in mouse and human small intestine and colon.” 2006 Joint International Society Meeting in Neurogastroenterology and GI Motility, Boston, MA, September 14-17, 2006 (论文交流).
24. Lei Sha, Linden, D. R., Farrugia, G. and Szurszewski, J. H.: Effect of NaHS on circular muscle tone and spontaneous inhibitory junction potentials (IJPs) in the mouse colon. Digestive Disease Week 2009, May 30 - June 4, 2009 (论文交流).
25. Lei Sha, Linden, D. R., Farrugia, G., Szurszewski, J. H.: Inhaled Hydrogen Sulfide is Anti-Inflammatory in Models of Murine Colitis that Involve Adaptive Immunity. The first international conference of hydrogen sulfide in biology and medicine. Shanghai, 2009 (论文交流)
26. Lei Sha,Linden, D. R., Farrugia, G. and Szurszewski, J. H.: Inhalation of hydrogen sulfide limits the development of TNBS-induced colitis. The 3rd International Meeting of Neurogastroenterology and Motility, Chicago, Illinois, 27-30 August 2009 (论文交流).
27. Lei Sha, Linden, D. R., Harmsen, W. S., Farrugia, G and Szurszewski, J. H.: Endogenous production of hydrogen sulfide hyperpolarizes circular muscle cells in the mouse colon. Digestive Disease Week 2010, New Orleans, Louisiana May 1 - 5, 2010 (论文交流).
28. Lei Sha, Linden, D. R., Harmsen, W. S., Farrugia, G and Szurszewski, J. H.: Membrane potential gradient in mouse colon is dependent on CO released from submucosal ganglion neurons. Digestive Disease Week 2010, New Orleans, Louisiana May 1 - 5, 2010 (学术报告).
29. Lei Sha, Linden, D. R., Harmsen, W. S., Farrugia, G and Szurszewski, J. H.: NaHS facilitates fast cholinergic synaptic input from central preganglionic nerves in mouse superior mesenteric ganglion. Digestive Disease Week 2011, Chicago, Illinois, May 7 - 10, 2011 (学术报告).
30. Lei Sha, Linden, D. R., Harmsen, W. S., Farrugia, G and Szurszewski, J. H.: Endogenous H2S produced predominantly by CSE selectively modulates central cholinergic synaptic input in mouse superior mesenteric ganglion. Society for Neuroscience Meeting, Washington DC, Nov. 12-16, 2011 (论文交流).
31. Lei Sha, Linden, D. R., Farrugia, G. and Szurszewski, J. H.: Endogenous H2S produced in prevertebral sympathetic ganglia predominantly by CSE in neurons and glia cells modulates central cholinergic synaptic input. Digestive Disease Week 2012, San Diego, California, May 19 - 22, 2012 (学术报告).
32. Lei Sha, Linden DR, Farrugia G, Szurszewski JH. Endogenous H2S produced by CSE selectively modulates central cholinergic synaptic input in mouse superior mesenteric ganglion. Joint Neurogastroenterology and Motility Meeting 2012, Bologna, Italy, Sept. 6 – 8, 2012 (论文交流).
33. Lei Sha, Linden, D., Farrugia, G, Szurszewski, JH. Endogenous H2S produced by CSE selectively facilitates acetylcholine release from synaptic terminals of central origin in mouse superior mesenteric ganglion. 2nd International Conference of Hydrogen Sulfide in Biology and Medicine, Atlanta, Georgia, Sept. 20-22, 2012 (论文交流).
34. Lei Sha, Linden DR, Farrugia G, Szurszewski, JH. H2S Enhances the Inhibitory Effect of Splanchnic Nerve Activation on Colonic Motility. Digestive Disease Week 2013, Orlando,Florida, May 18 - 21, 2013 (学术报告).
35. Lei Sha, G. Farrugia, L.H.T. Van der Ploeg, and J.H. Szurszewski. Effect of RM-131 on circular smooth muscle cells in human and mouse colon and on colonic intraluminal pressure in conscious mice. Digestive Disease Week 2014, Chicago, Illinois, May 3 - 6, 2014 (论文交流).
36. Lei Sha, Linden DR, Farrugia G, Szurszewski JH. H2S Inhibits NO Generation and This Inhibition Contributes to H2S -induced Muscle Contraction in Mouse Colon Smooth Muscle. Third International Conference on Hydrogen Sulfide in Biology and Medicine, Kyoto, Japan. June 4-6, 2014 (论文交流).
37. Qian Shen, Nan Zhang, Gary Lu and Lei Sha. Intrapancreatic neurons are a possible source of substance P in pancreas. The First Federation of Neurogastroenterology and Motility Meeting, Guangzhou, China, September 5-7, 2014 （论文交流）。
中国生理学会消化与营养委员会委员；辽宁神经科学会常务理事。美国消化协会会员，美国内分泌协会会员。Neurogastroenterology & Motility；American Journal of Physiology-Gastrointestinal and Liver Physiology的评审。