皮静波
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皮静波,教授、博士研究生导师,环境毒理学研究室主任、公共卫生学院院长,辽宁省高等学校攀登学者。教育经历1985-1990年:中国医科大学 预防医学 学士1992-1995年:中国医科大学 劳动卫生与职业病 硕士1998-2002年:日本筑波大学 医科学-环境生态系 博士工作经历(包括博士后及出国进修经历)1990-1992年:辽宁省食品卫生监督检验所 医师1995-1997年:中国医科大学 劳动卫生与职业病教研室 助教、讲师2002-2004年:美国国立环境健康科学研究院 (NIEHS) 博士后2004-2006年:美国哈姆纳健康科学研究院 (The Hamner Institutes) 博士后2006-2008年:美国哈姆纳健康科学研究院 Research Investigator2008-2010年:美国哈姆纳健康科学研究院 助理研究员2010-2013年:美国哈姆纳健康科学研究院 副研究员2013-2015年:中国医科大学 公共卫生学院 教授、常务副院长2015-至今:中国医科大学 公共卫生学院 教授、院长主持课题情况1.辽宁省重点研发指导计划项目:以氧化-还原稳态调控为基础建立糖尿病及其并发症防治策略及方法。项目编号:2019JH8/10300012;2020.01-2021.12;直接经费30万元。2.国家自然科学基金重点项目:慢性饮水型砷暴露对2型糖尿病的促发机制以及评价和防治方法研究。项目编号:81830099;2019.01-2023.12;直接经费294万元。3.国家自然科学基金面上项目:CNC-bZIP转录因子NRF1在砷致白色脂肪细胞新生及功能障碍中的作用机制研究。项目编号:81573106;2016.01-2019.12;直接经费65万元。4.美国国立环境健康科学研究院“杰出青年基金” (NIEHS-ONES Award): Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction. 2008-2014年;250万美元。5.英国联合利华-安全与环境评价中心研究基金(子课题):Nrf2 pathway mapping in human keratinocytes. 2013年;10万美元。6.“亨丁顿舞蹈症”基金会-杜克大学-哈姆纳合作课题(子课题):Characterization of the effects of “CHDI-compounds” on Nrf2/Nrf1-ARE activity. 2013年;3.9万美元7.美国化学工业协会基金 (子课题): Determination and computational modeling of Nrf2 pathway. 2009-2011 年;30万美元8.美国国立糖尿病消化系及肾疾病研究所青年基金 (NIDDK-K01 Award): Paradoxical roles of reactive oxygen species in pancreatic beta-cell function。2007-2010年;41万美元。9.美国化学工业协会基金 (子课题):Activation of Nrf2-mediated oxidative stress response by hypochlorous acid. 2007-2009年;30万美元10.国家自然科学基金青年基金: 慢性砷暴露对内源性一氧化氮代谢和功能的影响。2001-2003年;15万元。专利申请情况1. 富景奇,皮静波,王惠惠,陈承杰,包思萌,徐子晋。一种判断肿瘤易感小鼠模型的方法。申请号:2017107253601,申请公布号:CN107550932A,中国,申请公布日期:2018.01.092. Pi J, Andersen ME, Xue P, Peng H, Zhang Q. Compositions for modulating NRF2-ARE activity and their methods of use. International Application Number: PCT/US2014/046933, International Publication Number: WO2015/009879A1, USA; International Filing Date: 07/17/2014; International Publication Date: 01/22/2015.3. Nelson B, Pi J, Andersen ME. NRF2 inhibitors and compositions for treating mycobacterial infections. International Application Number: PCT/US2014/046936; International Publication Number: WO2015/009881A1, USA; International Filing Date: 07/17/2014; International Publication Date: 01/22/2015.研究生培养情况硕士生培养:2014年始,共招收26人,毕业4人(获硕士研究生国家奖学金3人次;获得校优秀硕士毕业研究生1人次),转博8人。 博士生培养:2008年始,联合培养11人,均已取得学位(获得美国毒理学会-机制毒理学分会 博士生一等奖1人;美国毒理学会-干细胞分会 博士生一等奖1人);2014年始,在中国医科大学招收博士生6人(毕业1人,获国家留学基金委资助去美国芝加哥大学联合培养1人) 博士后及访问学者培养:2007年始,共培养博士后3人,均已出站;2009年始,共培养访问学者2人, 均已按期回国。 获得奖励及荣誉称号情况2018年:辽宁省外专百人计划人选2015年:辽宁省第二批“十百千工程” “百人”层次人选2014年:辽宁省人民政府 辽宁友谊奖2013年:辽宁省高等学校攀登学者2006年:美国毒理学会-机制毒理学分会 Travel Award (博士后)2005年:美国毒理学会-分子生物学分会 博士后一等奖2004年:美国毒理学会-北卡来罗纳州分会 研究竞赛主席奖 博士后一等奖2004年:美国国立癌症研究所-第四届年度青年研究者大会 最佳大会报告奖2004年:美国毒理学会-致癌学分会 博士后一等奖2003年:美国国立卫生研究院-2003年度青年研究者突出成果奖2003年:美国毒理学会-金属毒理学分会 博士后一等奖1995年:辽宁省第二届青年科技工作者大会 一等奖其它皮静波简介:中国医科大学公共卫生学院教授、博士生导师。于1990和1995年在中国医科大学分别获得预防医学学士和劳动卫生/职业病专业硕士学位;2002年在日本筑波大学获得医科学-环境生态系博士学位;2002-2006年分别在美国国立环境健康科学研究院(NIEHS)和美国哈姆那健康科学研究院进行博士后研究工作;2006年始在美国哈姆那健康科学研究院先后任Research Investigator、助理研究员和副研究员。2013年9月以团队方式引进中国医科大学,担任公共卫生学院院长至今。长期致力于环境氧化应激的健康效应机制研究,近年重点关注转录因子Nrf2和Nrf1介导的适应性抗氧化反应在糖尿病、肥胖和癌症等慢性病发生和防治中的作用。发表SCI论文/英文论著110余篇,论文它引5500余次。曾获得美国NIEHS“杰出青年”研究基金(NIEHS-ONES Award)等2项NIH科研项目资助,并任美国毒理学会干细胞分会主席、以及多家SCI学术期刊编委或专刊的客座主编。目前受聘担任《Toxicology and Applied Pharmacology》杂志副主编、专刊主编及《Toxicology Reports》杂志副主编,并任中国毒理学会生化与分子毒理专业委员会和工业毒理专业委员会副主任委员。曾获评辽宁省高等学校攀登学者、辽宁省第二批“十百千工程”百人层次人选和辽宁省人民政府辽宁友谊奖。主持国家自然科学基金面上和重点项目研究领域
长期致力于环境氧化应激的健康效应及机制研究,主要方向包括:(1)糖尿病、肥胖、骨质疏松、恶性肿瘤等慢性病发病机制及防治策略研究;(2)环境氧化应激与慢性病发病发生发展的关系及机制研究;(3)适应性抗氧化反应调控机制及应用研究;(4)抗氧化反应调节剂的筛选及应用研究。""近期论文
1.Lyu H, Wang H, Li L, Zhu J, Chen F, Chen Y, Liu C1, Fu J, Yang B, Zhang Q, Xu Y*, Pi J* Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses. Free Radic Biol Med. 2020; 150:136-147. IF=5.6572.Li L, Fu J, Liu D, Sun J, Hou Y, Chen C, Shao J, Wang L, Wang X, Zhao R, Wang H, Andersen ME, Zhang Q, Xu Y, Pi J* Hepatocyte-specific Nrf2 Deficiency Mitigates High-Fat Diet-Induced Hepatic Steatosis: Involvement of Reduced PPARγ Expression. Redox Biol.2020; 30:101412. IF=7.7933.Xue P, Hou Y, Zuo Z, Wang Z, Ren S, Dong J, Fu J, Wang H, Andersen ME, Zhang Q, Xu Y∗, Pi J∗ Long Isoforms of NRF1 Negatively Regulate Adipogenesis via Suppression of PPARγ Expression. Redox Biol. 2020; 30:1014 IF=7.7934.Luan J, Fu J, Chen C, Jiao C, Kong W, Zhang Y, Chang Q, Wang Y, Li D, Illei GG, Kopp JB, Pi J*, Zhou H*, LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration. Arthritis Res Ther. 2019; 2019; 21:276. IF=4.1485.Qi H, Fu J, Luan J, Jiao C, Cui X, Cao X, Zhang Y, Wang Y, Kopp JB, Pi J*, Zhou H*. miR-150 inhibitor ameliorates adriamycin-induced focal segmental glomerulosclerosis. Biochem Biophys Res Commun. 2020; 522:618-625. IF=2.7056.Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y*, Fu J, Liu S, Wang H, Xu Y, Pi J*. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019; 668:310-317. IF =5.5897.Liu Z, Hou Y, Li L, Yang Y, Jia J, Hong Z, Li T, Xu Y, Fu J, Sun Y, Yamamoto M, Wang H*, Pi J*. Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic. Toxicol Appl Pharmacol. 2019; 367:62-70. IF=3.6168.Li L, Fu J*, Sun J, Liu D, Chen C, Wang H, Hou Y, Xu Y, Pi J*. Is Nrf2-ARE a potential target in mitigation of non-alcoholic fatty liver disease? Current Opinion in Toxicology. 2019; 13:35–44. 9.Pi J, Hayes JD, Yamamoto M. New Insights into Nuclear factor erythroid 2-related factors in Toxicology and Pharmacology. (Editorial) Toxicol Appl Pharmacol. 2019; 367:33-35 IF= 3.61610.Zhu J, Wang H*, Chen F, Lv H, Xu Z, Fu J, Hou Y, Xu Y, Pi J*. Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity. Toxicol Appl Pharmacol. 2018; 58:1-9. IF= 3.61611.Xu Y., Fu J., Wang H., Hou Y., Pi J. (2019) Arsenic Exposure and Lifestyle-Related Diseases. In: Yamauchi H., Sun G. (eds) Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-13-2565-6_612.Sun J, Fu J*, Li L, Chen C, Wang H, Hou Y, Xu Y, Pi J*. Nrf2 in alcoholic liver disease. Toxicol Appl Pharmacol. 2018; 57:62-69. IF= 3.61613.Sun J, Fu J*, Zhong Y, Li L, Chen C, Wang X, Wang L, Hou Y, Wang H, Zhao R, Zhang X, Yamamoto M, Xu Y, Pi J*. NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice. Food Chem Toxicol. 2018; 21:495-503. IF= 3.97714.Hou Y, Liu Z, Zuo Z, Gao T, Fu J, Wang H, Xu Y, Liu D, Yamamoto M, Zhu B, Zhang Y, Andersen ME, Zhang Q, Pi J*. Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice. Biochem Biophys Res Commun. 2018; 3:264-270. IF= 2.55915.Wang H, Zhu J, Liu Z, Lv H, Lv P, Chen F, Fu J, Hou Y, Zhao R, Xu Y, Zhang Q, Pi J*. Silencing of long isoforms of Nuclear factor erythroid 2-related factor 1 primes macrophages towards M1 polarization. Free Radic Biol Med. 2018;117:37-44. IF=5.606.16.Fu J, Zheng H, Cui Q, Chen C, Bao S, Sun J, Li L, Yang B, Wang H, Hou Y, Xu Y, Xu Y, Zhang Q, Pi J*. Nfe2l1 silenced insulinoma cells acquire aggressiveness and chemo-resistance. Endocr Relat Cancer. 2017;pii: ERC-17-0458. doi: 10.1530/ERC-17-0458. IF=5.267.17.Wang H, Zhu J, Li L, Li Y, Lv H, Xu Y, Sun G, Pi J*. Effects of Nrf2 deficiency on arsenic metabolism in mice. Toxicol Appl Pharmacol. 2017; 37:111-119. IF=3.79118.Kong W, Fu J, Liu N, Jiao C, Guo G, Luan J, Wang H, Yao Y, Wang L, Yamamoto M, Pi J*, Zhou H*. Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. Nephrol Dial Transpl.2018; 33:771-783. IF=4.4719.Chen F, Wang H, Zhu J, Zhao R, Xue P, Zhang Q, Nelson MB, Qu W, Feng B*, Pi J*. Camptothecin suppresses NRF2-ARE activity and sensitizes hepatocellular carcinoma cells to anticancer drugs. Br J Cancer. 2017; 117:1495-1506. IF=6.17620.Cui Q, Fu J*, Hu Y, Li Y, Yang B, Li L, Sun J, Chen C, Sun G, Xu Y, Zhang Q, Pi J*. Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic β cells to arsenite-induced cytotoxicity. Toxicol Appl Pharmacol. 2017; 329:67-74. IF=3.79121.Fu J, Cui Q, Yang B, Hou Y, Wang H, Xu Y, Wang D, Zhang Q, Pi J*. The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response. Food Chem Toxicol. 2017; 100:161-167. IF=3.77822.Wu R, Wu X, Wang H, Fang X, Li Y, Gao L, Sun G, Pi J*, Xu Y*. Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice. Sci Rep. 2017 Mar 17;7:44424. doi: 10.1038/srep44424.23.Zhu J, Wang H, Chen F, Fu J, Xu Y*, Hou Y, Kou HH, Zhai C, Zhang Q, Andersen ME , Pi J*. An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and potential applications in cancer therapy. Free Radic Biol Med. 2016; 99: 544-556. IF=5.60624.Fu J, Hou Y, Xue P, Wang H, Xu Y, Qu W, Zhang Q, Pi J*. Nrf2 in Type 2 diabetes and diabetic complications: Yin and Yang. Current Opinion in Toxicology. 2016; 1:9-19.25.Chen Y, Xu Y*, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J*. The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study. Biochem Biophys Res Commun. 2016; 478:87-92.26.Peng H, Wang H, Xue P, Hou Y, Dong J, Zhou T, Qu W, Peng S, Li J, Carmichael PL, Nelson B, Clewell R, Zhang Q, Andersen ME, Pi J*. Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. Toxicol Appl Pharmacol. 2016; 292:1-7.27.Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W*, Qu W, Zhang Q, Andersen ME, Pi J*. CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion. Antioxid Redox Signal. 2015; 22:819-31.28.Fu J, Zheng H, Wang H, Yang B, Zhao R, Lu C, Liu Y, Hou Y, Xu Y, Zhang Q, Qu W, Pi J*. Protective role of nuclear factor E2-related factor 2 against acute oxidative stress-induced pancreatic β-cell damage. Oxidative Med and Cellular Longevity. 2015; Article ID 639191.29.Pi J*, Zhang Q, Andersen ME. ROS and antioxidants in pancreatic β-cell function: Yin and Yang. (Book chapter). Systems biology of free radicals and anti-oxidants. Springer-Verlag Berlin Heidelberg. 2014; DOI 10.1007/978-3-642-30018-9_159.30.Chen Y, Xue P, Hou Y, Zhang H, Zheng H, Zhou T, Qu Q, Teng W*, Zhang Q, Andersen ME, Pi J*. Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013; 273: 435-441.31.Lv P, Xue P, Dong J, Peng H, Clewell R, Wang A, Wang Y, Peng Q, Qu W, Zhang Q, Andersen ME, Pi J*. Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages. Toxicol Appl Pharmacol. 2013; 272:697-702.32.Fu J, Zhang Q, Woods CG, Zheng H, Yang B, Qu W, Andersen ME, Pi J*. Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidants. Pharmaceutical Res. 2013; 30:2248–2259.33.Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Collins S, Yamamoto M, Zhang Q, Andersen ME, Pi J*. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes. 2013; 62:845-854.34.Hou Y, Xue P, Woods CG, Wang X, Fu J, Yarborough K, Qu W, Zhang Q, Andersen ME, Pi J*. Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response. Environ. Health Perspect. 2013; 121:237-243.35.Yang B, Fu J, Zheng H, Xue P, Yarborough K, Woods CG, Hou Y, Zhang Q, Andersen ME, Pi J*. Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage. Toxicol Appl Pharmacol. 2012; 264:315-323.36.Zhan L, Zhang H, Zhang Q*, Woods CG, Chen Y, Xue P, Dong J, Tokar EJ, Xu Y, Hou Y, Fu J, Yarborough K, Wang A, Qu W, Waalkes MP, Andersen ME, Pi J*. Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small cell lung carcinoma cells. Free Radic Biol Med. 2012; 53:758-768.37.Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J*. Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes. Environ. Health Perspect. 2012; 4:583-589.38.Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J*. Involvement of nuclear factor E2-related factor 2 in transcriptional regulation of CCAAT/enhancer-binding protein β expression in the early stage of adipogenesis. Free Radic Biol Med. 2012; 52:462-472.39.Xue P, Hou Y, Zhang Q, Woods CG, Yarborough K, Liu H, Sun G, Andersen ME, Pi J*. Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: Involvement of the adaptive antioxidant response. Biochem Biophys Res Commun. 2011; 407: 360-365.40.Zhao R, Hou Y, Xue P, Woods CG, Fu J, Feng B, Guan D, Sun G, Chan JY, Waalkes WP, Andersen ME, Pi J*. Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. Environ. Health Perspect. 2011; 119: 56-62.41.Pi J#,*, Leung L#, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E., Lee C, Lau J, Kurtz TW, Chan JY*. Deficiency in the nuclear factor E2-related factor 2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem. 2010; 285:9292-300.42.Fu J, Woods CG, Yehuda-Shnaidman E., Zhang Q, Wong V, Collins S, Sun G, Andersen ME, Pi J*. Arsenic impairs glucose-stimulated insulin secretion in pancreatic beta-cells: involvement of Nrf2-mediated antioxidant response. Environ. Health Perspect. 2010; 118:864-870.43.Pi J* and Collins S*. ROS and UCP2 in pancreatic β-cell function. Diabetes Obes. Metab. 2010; 12S2:141-148.44.Pi J*, Freeman ML, Yamamoto M. Nrf2 in toxicology and pharmacology: the good, the bad and the ugly? (Editorial) Toxicol Appl Pharmacol. 2010; 244: 1-3.45.Pi J*, Zhang Q, Fu J, Woods CG, Collins S, Andersen ME. ROS signaling and oxidative stress in pancreatic beta-cell function. Toxicol Appl Pharmacol. 2010; 244:77-83.46.Woods CG, Fu J, Pluta L, Yang L, Zhang Q, Thomas RS, Mckee RH, Andersen ME, Pi J*. Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages. Toxicol Appl Pharmacol. 2009; 238:27-29.47.Pi J*, Bai Y, Daniel K, Dianxin Liu, Edelstein D, Brownlee M, Corkey BE, Collins S*. Persistent oxidative stress due to absence of UCP2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009; 150:3040-3048.48.Pi J*, Diwan BA, Qu W, Liu J, Sun Y, Miroslav Styblo, Waalkes MP*. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med. 2008; 45:651-658.49.Pi J*, Zhang Q, Wong V, Woods C, Collins S, Andersen ME. Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid. Toxicol Appl Pharmacol. 2008; 226:236-43.50.Pi J*, Bai Y, Zhang Q, Floering LM, Wong V, Daniel K, Reece JM, Deeney JT, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007; 56:1783-1791.51.Pi J*, Bai Y, Reece JM, William J, Liu D, Freeman ML, Fahl WE, Shugar D, Liu J, Qu W, Collins S, Waalkes MP. Molecular mechanism of Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. Free Radic Biol Med. 2007; 42:1797-806.52.Pi J, Yamauchi H, Sun G, Yoshida T, Aikawa H, Fujimoto W, Iso H, Cui R, Waalkes MP, Kumagai Y. Vascular dysfunction in patients with chronic arsenosis can be reversed by reduction of arsenic exposure. Environ. Health Perspect. 2005; 113:339-341.53.Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP. Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential roles in skin co-carcinogenesis. Int J Cancer. 2005; 116:20-26.54.Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: Involvement of hydrogen peroxide. Exp Cell Biol. 2003; 290:234-245.55.Pi J, Horikuchi S, Sun Y, Nikaido M, Shimojo N, Hayashi T, Yamauchi H, Itoh K, Yamamoto M, Sun G, Waalkes MP, Kumagai Y. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits. Free Radic Biol Med. 2003; 35:102-13.56.Pi J, Yamauchi H, Kumagai Y, Sun G, Yoshida T, Aikawa H, Hopenhayn-Rich C, Shimojo N. Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ. Health Perspect. 2002; 110:331-336.57.Pi J, Kumagai Y, Shimojo N. Improved method for simultaneous determination of L-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography. J Chromatogr B. 2000; 742:199-203.58.Pi J, Kumagai Y, Sun G, Yamauchi H, Yoshida T, Iso H, Endo A, Yu L, Yuki K, Miyauchi T, Shimojo N. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in Inner Mongolia. Free Radic Biol Med. 2000; 28:1137-42.教材:2013年 全国高等教育医学数字化规划教材(国家医学电子书包) 《预防医学》副主编。2015-2019年 国家医师资格考试模拟试卷(公共卫生职业医师),人民卫生出版,主编 2015-2019年 国家医师资格考试模拟试卷(公共卫生职业助理医师),人民卫生出版社,主编期刊:2019-至今:Toxicology and Applied Pharmacology 专刊客座主编2017-2018:Toxicology and Applied Pharmacology 专刊客座主编2013-至今:Toxicology and Applied Pharmacology 副主编2016-至今:Toxicology Reports 副主编2012-2013年:Oxidative Medicine and Cellular Longevity 专刊客座主编2011-2013年:Chemical Research in Toxicology 编委2009-2010年:Toxicology and Applied Pharmacology 专刊客座主编2008-2012年:Toxicology and Applied Pharmacology 编委2019-现在:中华预防医学会卫生毒理分会第6届委员会 顾问2018-现在: 辽宁省预防医学会/辽宁省核与辐射安全防护协会/辽宁省环境科学学会环境与健康分会会长2018-现在: 中国医防整合联盟副理事长2017-现在: 中国毒理学会生化与分子毒理专业委员会副主任委员2017-现在: 中国毒理学会工业毒理专业委员会副主任委员2017-现在: 中国环境诱变剂学会常务委员2015-现在: 辽宁省预防医学会卫生毒理学专业委员会主任委员2014-现在: 中华预防医学会卫生毒理分会第五届委员会常务委员2014-现在: 中华预防医学会公共卫生教育分会第四届委员会委员2014-现在: 中国环境诱变剂学会毒性测试与替代方法专业委员会第一届委员会常务委员2014-2015: 美国毒理学会-干细胞分会 主席2012-2013: 美国毒理学会-干细胞分会 副主席2010-2011: 美国自由基生物学和医学学会 学术奖励委员会 委员2010-2011: 美国国立环境健康研究所 环境污染物与糖尿病和肥胖关系评价组 砷镉分组成员2010-2013: 美国 East Carolina University 毒理药理学系 博士学位指导及答辩委员会成员2009-2012: 美国国立环境健康研究院 学术奖励委员会评审2006-2013年:美国糖尿病学会科技会员1998-2002年:日本卫生学会会员 相关热点
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