个人简历

魏彩虹， 1966年2月生，甘肃省庄浪人，博士，研究员，博士生导师。1989年获甘肃农业大学学士学位；2004年获甘肃农业大学硕士学位；2012年获甘肃农业大学博士学位。2004年至今在中国农业科学院北京畜牧兽医研究所工作。主要从事动物遗传资源评价、动物遗传育种与生物技术方面的研究。现任肉羊遗传育种创新团队骨干专家；国家肉羊产业技术体系岗位科学家；农业部肉羊标准化建设专家，贵州农业委员会养羊特聘专家，北京市自然基金评定委员会评审专家; 中国畜牧兽医学会养羊学分会理事。\r
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研究方向与成果\r
1990年以来，主要从事动物遗传育种与生物技术方面的研究。研究制定了《标准化养殖场 肉羊》标准（NY/T2665-2014）\r
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研究成果先后荣获\r
2001年甘肃省科技进步二等奖：“猪脂肪细胞抗体和代谢酶特性及其与生产性能关系的应用研究”（第2完成人）\r
2003年甘肃省科技进步二等奖：“甘肃黑猪合成系培育及利用的研究”（第6完成人）\r
2013年天津市科技进步三等奖：“杜泊羊的引进、选育与示范”（第2完成人）\r
2014年中国农业科学院科技成果二等奖：“中国肉羊优异基因发掘利用与群体遗传改良关键技术的研究应用”（第2完成人）\r
2014年内蒙古自治区科技进步二等奖：“巴美肉羊高繁新品系”（第4完成人）\r
2015年中华农业科技二等奖：《畜禽标准化养殖技术图册》系列丛书：（第9完成人）\r
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三、在研项目\r
1. “十三五”国家肉羊产业技术体系岗位科学家（编号：CARS-39）\r
2. 国家自然科学基金面上项目“LncRNA-OAR分子对绵羊骨骼肌发育调控机制研究”（编号：31672380）\r
3. 农科院“绿色养殖协同创新课题”骨干

研究领域

""主要从事动物遗传资源评价、动物遗传育种与生物技术方面的研究。""""

近期论文

Lu Z, Chu M, Li Q, Jin M, Fei X, Ma L, Zhang L, Wei C.Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep. Animals (Basel). 2019 Jun 24;9(6). pii: E387. doi: 10.3390/ani9060387.\r
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Lu ZK, Ma YJ, Li Q, Liu EM, Jin ML, Zhang LP, Wei CH. The role of N(6)-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries). Cell Stress Chaperones, 2019. 24(2): 333-342.\r
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Wei C, Wu M, Wang C, Liu R, Zhao H, Yang L, Liu J, Wang Y, Zhang S, Yuan Z, Liu Z, Hu S, Chu M, Wang X, Du L. Long non-coding RNA lnc-SEMT modulates IGF2 expression by sponging miR-125b1 to promote sheep muscle differention. Cell Physiol Biochem. 2018;49(2):447-462. doi: 10.1159/000492979. Epub 2018 Aug 28.\r
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Mingming WU, Lixin DU, Yuqin WANG, Ran DI, Zengkui LU, Enmin LIU, Huijing ZHAO, Qing LI, Xiaogang WANG, Caihong WEI. Double-muscled phenotype in mutant sheep directed by the CRISPR-Cas9 system. Clon Transgen 2018, 6:2 DOI: 10.4172/2168-9849.1000161 \r
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Qing Li, Ruizao Liu, Huijing Zhao, Ran Di, Zengkui Lu, Enmin Liu, Yuqing Wang, Mingxing Chu, and Caihong Wei, Identification and Characterization of Long Noncoding RNAs in Ovine Skeletal Muscle, Animals, 2018, 8(7):127-142.\r
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Lu ZK, Du LX, Liu RZ, Di R, Zhang LP, Ma YJ, Li Q, Liu EM, Chu MX, Wei CH. MiR-378 and BMP-Smad can influence the proliferation of sheep myoblast. Gene, 2018. 674: 143-150.\r
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Wei CH, Wang HH, Liu G, Zhao FP, Kijas JW, Ma YJ, Lu J, Zhang L, Cao JX, Wu MM, Wang GK, Liu RZ, Liu Z, Zhang SZ, Liu CS, Du LX. Genome-wide analysis reveals adaptation to high-altitude in Tibetan sheep. Scientific Reports, 2016, 6:26770. \r
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Cao JX, Wei CH#, Liu DM, Wang HH, Wu MM, Xie ZY, Capellini TD, Zhang L, Zhao FP, Li L, Zhong T, Wang LJ, Lu J, Liu RZ, Zhang SF, Du YF, Zhang HP, Du LX. DNA methylation Landscape of body size variation in sheep. Scientific Reports, 2015, 5:13950.\r
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Wu MM, Wei CH#, Lian ZX, Liu RZ, Zhu CY, Wang HH, Cao JX, Shen YL, Zhao FP, Zhang L, Mu Z, Wang YY, Wang XG, Du LX, Wang CD. Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system. Scientific Reports, 2016, 6:24360.\r
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Xu LY, Zhao FP, Ren HX, Li L, Lu J, Liu JS, Zhang SF, Liu GE, Song JZ, Zhang L, Wei CH*, Du LX. Co-expression analysis of fetal weight-related genes in ovine skeletal muscle during mid and late fetal development stages. International Journal of Biological Sciences, 2014, 10(9):1039-1050. \r
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Wei CH, Wang HH, Liu G, Wu MM, Cao JX, Liu Z, Liu RZ, Zhao FP, Zhang L, Lu J, Liu CS, Du LX. Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds. BMC Genomics, 2015, 16(1):194.\r
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Wei CH, Lu J, Xu LY, Liu G, Wang ZG, Zhao FP, Zhang L, Han X, Du LX, Liu CS. Genetic structure of Chinese indigenous goats and the special geographical structure in the Southwest China as a geographic barrier driving the fragmentation of a large population. PLoS One, 2014, 9(4):e94435. \r
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Wei CH, Ren HX, Xu LY, Li L, Liu RZ, Zhang L, Zhao FP, Lu J, Zhang XN, Du LX. Signals of Ezh2, Src, and Akt involve in myostatin-Pax7 pathways regulating the myogenic fate determination during the sheep myoblast proliferation and differentiation. PLoS One, 2015, 10(3):e0120956.\r
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Wang HH, Zhang L, Cao JX, Wu MM, Ma XM, Liu Z, Liu RZ, Zhao FP, Wei CH*, Du LX. Genome-wide specific selection in three domestic sheep breeds. PLoS One, 2015, 10(6):e0128688.\r
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Wei CH, Li L, Su HW, Xu LY, Lu J, Zhang L, Liu WZ, Ren HX, Du LX. Identification of the crucial molecular events during the large-scale myoblast fusion in sheep. Physiol Genomics, 2014, 46(12):429-440. \r
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Lu J, Wei CH#, Zhang XN, Xu LY, Zhang SF, Liu JS, Cao JX, Zhao FP, Zhang L, Li BC, Du LX. The effect of myostatin silencing by lentiviral-mediated RNA interference on goat fetal fibroblasts. Molecular Biology Reports, 2013, 40(6):4101-4108.\r
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Cao JX, Wei CH#, Zhang SZ, Capellini TD, Zhang L, Zhao FP, Li L, Zhong T, Wang LJ, Du LX, Zhang HP. Screening of reproduction-related single-nucleotide variations from MeDIP-seq data in sheep. Molecular Reproduction & Development, 2016, 83(11):958-967. \r
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Yuan ZH, Liu EM, Liu Z, Kijas JW Zhu CY, Hu SJ, Ma XM, Zhang L, Du LX, Wang HH, Wei CH*. Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep. Animal Genetics, 2017, 48(1):55-66. \r
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Zhao FP, Wei CH#, Zhang L, Liu JS, Wang GK, Zeng T, Du LX. A genome scan of recent positive selection signatures in three sheep populations. Journal of Integrative Agriculture, 2016, 15(1):162-174.\r
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1.专利： \r
一种优质肉羊新品系的培育方法（ZL 2014 I 0396414. 0）\r
畜体分选装置（ZL 2014 2 0353375.0）\r
动物引导装置（ZL 2014 2 0354264.2）\r
一种努伏山羊品系的培育方法(ZL 2010 I0212554.X)\r
优质肉羊品系的培育方法（ZL 2012 I 0055954.3）\r
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2.专著：\r
《肉羊标准化养殖图册》（21.9万字）\r
《现代肉羊生产技术大全》（51万字）