个人简历

2019-至今：入选中国农业大学“人才培育发展支持计划”青年新星A类，校级“功能核酸”青年科学家创新团队，特聘研究员；
2013.04-2014.09：美国马里兰大学，访问学者；
2006.07-至今：：中国农业大学，任教讲师、副教授；
2001.09-2006.06：中国农业大学，工学博士；
1997.09-2001.06：中国农业大学，工学学士；
2019年：荣获 中国农业大学“优秀教师”荣誉称号；
2014年：荣获 第二届“师恩杯”我最喜爱的导师；
课题项目
1.国家自然基金重大仪器专项“单细胞代谢毒理学效应超灵敏精准质谱分析装置研制”（2020-2024） 子课题主持
2.国家自然基金面上项目“基于复合纳米材料的食源性致病微生物超灵敏等温核酸生物传感器及智能定量装备的研究”（2019-2022）主持
3.国家自然基金面上项目“基于“磁三核酸-肽核酸”的食源性致病微生物条形码纸基光学传感器的研究”（2016-2019）主持
4.转基因专项“基因组编辑新型转基因动物产品安全评价技术研究”（2018-2019）主持
5.转基因专项“复合性状转基因成分检测、溯源技术及标识阈值研究 转基因专项“ （2014-2016）主持
6.转基因专项“转基因产品现场快速检测仪器设备研发”（2018-2020）主持
7.863计划“食用农产品病原菌分子检测技术开发及生物安全控制”（2012-2015）子课题主持
8.北京市科技新星“食源性致病菌新型等温PCR现场快速检测及核酸试纸条关键技术研究”（2014-2017）主持
9. 北京市科技新星交叉项目“食源性致病菌现场快速检测核酸层析试纸条系列产品的研发”（2017-2018）主持
10.教育部新世纪人才项目“ASK1参与调控赭曲霉毒素A诱导的肾细胞毒性作用机制研究”（2014-2016）主持

研究领域

""1.功能核酸生物传感、纳米材料及靶向药物
2.精准毒理/营养检测与评价技术
3.合成生物学及生物技术食品安全""""

近期论文

1. Zhang, B.; Zhu, L.; Dai, Y.; Li, H.; Huang, K.*; Luo, Y.; Xu, W.*, An in vitro attempt at precision toxicology reveals the involvement of DNA methylation alteration in ochratoxin A-induced G0/G1 phase arrest. Epigenetics 2020, 15 (1-2), 199-214.
2. Shao, X.; Feng, Y.; Zhu, L.; Zhang, Y.; Luo, Y.; Mei, X.; Yuan, C.; Xu, W.*, Three dimensional DNA nanotracks: A novel method for ultrasensitive and visible mercury (II) detection. Sensors & Actuators B: Chemical 2020, 303, 126988-126988.
3. Zhu, L.; Miao, M.; Shao, X.; Du, Z.; Huang, K.; Luo, Y.; Xu, W.*, A Universal Electrochemical Biosensor Using Nick-HCR Nanostructure as Molecular Gate of Nanochannel for Detecting Chromium(III) Ions and MicroRNA. Analytical Chemistry 2019, 91 (23), 14992-14999.
4. Zhu, L.; Li, S.; Shao, X.; Feng, Y.; Xie, P.; Luo, Y.; Huang, K.; Xu, W.*, Colorimetric detection and typing of E. coli lipopolysaccharides based on a dual aptamer-functionalized gold nanoparticle probe. Microchimica Acta 2019, 186 (2), 111-111.
5. Xu, W.; He, W.; Du, Z.; Zhu, L.; Huang, K.; Lu, Y.*; Luo, Y.*, Functional Nucleic Acids‐Nanomaterials: Development, Properties, and Applications. Angewandte Chemie International Edition 2019, doi:10.1002/ange.201909927
6. Xiao, X.; Zhu, L.; He, W.; Luo, Y.; Xu, W.*, Functional nucleic acids tailoring and its application. Trends in Analytical Chemistry 2019, 118, 138-157.
7. Tian, J.; Chu, H.; Zhang, Y.; Li, K.; Tian, H.; Zhang, X.; Xu, W.*, TiO2 Nanoparticle-Enhanced Linker Recombinant Strand Displacement Amplification (LRSDA) for Universal Label-free Visual Bioassays. ACS Applied Materials & Interfaces 2019, 11, 46504-46514.
8. Song, H.; Zhang, Y.; Wang, S.; Huang, K.; Luo, Y.; Zhang, W.; Xu, W.*, Label-free polygonal-plate fluorescent-hydrogel biosensor for ultrasensitive microRNA detection. Sensors & Actuators B: Chemical 2019, 306, 127554-127554.
9. Song, H.; Zhang, Y.; Cheng, P.; Chen, X.; Luo, Y.; Xu, W.*, A rapidly self-assembling soft-brush DNA hydrogel based on RCA products. Chemical Communications 2019, 55 (37), 5375-5378.
10. He, W.; Li, S.; Wang, L.; Zhu, L.; Zhang, Y.; Luo, Y.; Huang, K.; Xu, W.*, AuNPs-DNAzyme molecular motor biosensor mediated by neighborhood click chemistry reactions for the ultrasensitive detection of microRNA-155. Sensors & Actuators B: Chemical 2019, 290, 503-511.
11. Guo, M.; Wang, J.; Du, R.; Liu, Y.; Chi, J.; He, X.; Huang, K.; Luo, Y.; Xu, W.*, A test strip platform based on a whole-cell microbial biosensor for simultaneous on-site detection of total inorganic mercury pollutants in cosmetics without the need for predigestion. Biosensors & Bioelectronics 2019, 111899-111899.
12. Guo, M.; Du, R.; Xie, Z.; He, X.; Huang, K.; Luo, Y.; Xu, W.*, Using the promoters of MerR family proteins as “rheostats” to engineer whole-cell heavy metal biosensors with adjustable sensitivity. Journal of Biological Engineering 2019, 13 (1), 1-9.
13. Cheng, N.; Song, Y.; Shi, Q.; Du, D.; Liu, D.; Luo, Y.; Xu, W.*; Lin, Y.*, Au@ Pd Nanopopcorn and Aptamer Nanoflower Assisted Lateral Flow Strip for Thermal Detection of Exosomes. Analytical Chemistry 2019, 91 (21), 13986-13993.
14. Xu, Y.; Wei, Y.; Cheng, N.; Huang, K.*; Wang, W.; Zhang, L.; Xu, W.*; Luo, Y., Nucleic acid biosensor synthesis of an all-in-one universal blocking linker recombinase polymerase amplification with a peptide nucleic acid-based lateral flow device for ultrasensitive detection of food pathogens. Analytical Chemistry 2018, 90 (1), 708-715.
15. Feng, Y.; Shao, X.; Huang, K.; Tian, J.; Mei, X.; Luo, Y.*; Xu, W.*, Mercury nanoladders: a new method for DNA amplification, signal identification and their application in the detection of Hg (II) ions. Chemical Communications 2018, 54 (58), 8036-8039.
16. Zhu, L.; Zhang, B.; Dai, Y.; Li, H.; Xu, W.*, A review: epigenetic mechanism in ochratoxin a toxicity studies. Toxins 2017, 9 (4), 113-113.
17. Zhu, L.; Shao, X.; Luo, Y.; Huang, K.; Xu, W.*, Two-Way Gold Nanoparticle Label-Free Sensing of Specific Sequence and Small Molecule Targets Using Switchable Concatemers. ACS Chemical Biology 2017, 12 (5), 1373-1380.
18. Zhang, L.; Chen, Y.; Cheng, N.; Xu, Y.; Huang, K.; Luo, Y.; Wang, P.; Duan, D.; Xu, W.*, Ultrasensitive detection of viable Enterobacter sakazakii by a continual cascade nanozyme biosensor. Analytical Chemistry 2017, 89 (19), 10194-10200.
19. Zhang, B.; Huang, K.; Zhu, L.; Luo, Y.; Xu, W.*, Precision toxicology based on single cell sequencing: an evolving trend in toxicological evaluations and mechanism exploration. Archives of Toxicology 2017, 91 (7), 2539-2549.
20. Xu, W.; Tian, J.; Shao, X.; Zhu, L.; Huang, K.; Luo, Y.*, A rapid and visual aptasensor for Lipopolysaccharides detection based on the bulb-like triplex turn-on switch coupled with HCR-HRP nanostructures. Biosensors & Bioelectronics 2017, 89, 795-801.
21. Cheng, N.; Xu, Y.; Luo, Y.; Zhu, L.; Zhang, Y.; Huang, K.; Xu, W.*, Specific and relative detection of urinary microRNA signatures in bladder cancer for point-of-care diagnostics. Chemical Communications 2017, 53 (30), 4222-4225.
22. Cheng, N.; Shang, Y.; Xu, Y.; Zhang, L.; Luo, Y.; Huang, K.; Xu, W.*, On-site detection of stacked genetically modified soybean based on event-specific TM-LAMP and a DNAzyme-lateral flow biosensor. Biosensors & Bioelectronics 2017, 91, 408-416.
23. Xu, W.; Cheng, N.; Huang, K.; Lin, Y.; Wang, C.; Xu, Y.; Zhu, L.; Du, D.; Luo, Y.*, Accurate and easy-to-use assessment of contiguous DNA methylation sites based on proportion competitive quantitative-PCR and lateral flow nucleic acid biosensor. Biosensors & Bioelectronics 2016, 80, 654-660.
24. Chen, Y.; Cheng, N.; Xu, Y.; Huang, K.; Luo, Y.; Xu, W.*, Point-of-care and visual detection of P. aeruginosa and its toxin genes by multiple LAMP and lateral flow nucleic acid biosensor. Biosensors & Bioelectronics 2016, 81, 317-323.
25. Guo, M.; Huang, K.; Chen, S.; Qi, X.; He, X.; Cheng, W.; Luo, Y.; Xia, K.; Xu, W.*, Combination of metagenomics and culture-based methods to study the interaction between ochratoxin a and gut microbiota. Toxicological Sciences 2014, 141 (1), 314-323.