个人简历

李少芳，博士，副教授。1998年在东北师范大学获得理学学士学位，2002年在中国科学院遗传与发育生物学研究所获得理学硕士学位，2014年在美国加州大学河滨分校获得理学博士学位。2015-2017年在加州大学洛杉矶分校和河滨分校从事博士后研究。2017年入选中国农业大学“优秀人才”引进计划。近年来在PNAS, Molecular Plant, Nucleic Acid Research, Genome Research, Elife 等国际杂志上发表研究论文十余篇。
学习与工作经历
1998/09－2002/07，东北师范大学，理学学士
2002/09－2005/07，中国科学院遗传与发育生物学研究所，理学硕士
2009/07－2014/12，加州大学河滨分校，理学博士
2015/01－2016/12，加州大学洛杉矶分校，博士后
2017/01－2017/12，加州大学河滨分校，博士后
2018/01－至今，中国农业大学生物学院

研究领域

充分发挥生物信息学和基因组编辑技术的优势，研究控制植物表型相关的表观遗传修饰、RNA转录调控和基因调控网络""

近期论文

Liu L, Kuang Y, Yan F, Li Shaofang, Ren B, Gosavi G, Spetz C, Li X, Wang X, Zhou X, Zhou H. 2020. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of OsTubA2. Plant Biotechnol J. Jun 14. doi: 10.1111/pbi.13430
Kuang Y#, Li Shaofang#, Ren B, Yan F, Spetz C, Li X, Zhou X, Zhou H. 2020. Base-Editing-Mediated Artificial Evolution of OsALS1 in planta to Develop Novel Herbicide-Tolerant Rice Germplasms. Mol Plant. Jan 27. pii: S1674-2052(20)30010-1(#Co-first author)
Zhu Y, Hu X, Duan Y, Li Shaofang, Wang Y, Rehman AU, He J, Zhang J, Hua D, Yang L, Wang L, Chen Z, Li C, Wang B, Song CP, Sun Q, Yang S, Gong Z. 2020. The Arabidopsis Nodulin Homeobox Factor AtNDX Interacts with AtRING1A/B and Negatively Regulates Abscisic Acid Signaling. Plant Cell. pii: tpc.00604.2019
Li Shaofang#,*,Wang Y#, Zhao Y, Zhao XX, Chen X, Gong Z. 2020. Global co-transcriptional splicing in Arabidopsis and the correlation with splicing regulation in mature RNAs (#Co-first author)(*corresponding author). Mol Plant. Feb;13(2):266-277
Wang Y#, Li Shaofang#, Zhao Y, Gong Z, Mo B, Xia Yi, Chen X. 2019. The RNA NAD+ cap is widespread in the Arabidopsis transcriptome and probably promotes translation. PNAS. Jun;116(24) 12094-12102;(#Co-first author)
Wang L, Wang C, Li X, Cheng J, Li Shaofang, Zhu J, Gong Z. 2019. Peroxisomal β-oxidation regulates histone acetylation and DNA methylation in Arabidopsis. PNAS. May;116(21) 10576-10585;
Ren B, Liu L, Li Shaofang, Kuang Y, Wang J, Zhang D, Zhou X, Lin H, Zhou H. 2019. Cas9-NG greatly expands the targeting scope of genome-editing toolkit by recognizing NG and other atypical PAMs in rice. Mol Plant.Jul;12(7):1015-1026
Wang S, Quan L, Li Shaofang, You C, Zhang Y, Gao L, Zeng L, Liu L, Qi Y, Mo B, Chen X. 2019.The PROTEIN PHOSPHATASE4 Complex Promotes Transcription and Processing of Primary microRNAs in Arabidopsis. Plant Cell. Feb;31(2):486-501
回国前文章：
Li Shaofang, Xing Y. SQUID: Stringent quantitation of unspliced introns by deep-sequencing. (https://github.com/Xinglab/SQUID)
Su Z, Zhao L, Zhao Y, Li Shaofang, Won S, Cai H, Wang L, Li Z, Chen P, Qin Y, Chen X. 2017. The THO Complex Non-Cell-Autonomously Represses Female Germline Specification through the TAS3-ARF3 Module. Curr Biol. 27(11):1597-1609
Li D, Palanca AMS, Won SY, Gao L, Feng Y, Vashisht AA, Liu L, Zhao Y, Liu X, Wu X, Li Shaofang, Le B, Kim YJ, Yang G, Li S, Liu J, Wohlschlegel JA, Guo H, Mo B, Chen X, Law JA. 2017. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. Elife. Apr 28;6
Li S#, Le B#, Ma X#, Li Shaofang#, You C, Liu L, Gao L, Shi T, Zhao Y, Chen X. 2016. Endoplasmic reticulum as a hub organizing the activities of microRNAs and a subset of endogenous siRNAs in Arabidopsis. Elife. Dec 12;5 (#Co-first author)
Li Shaofang#, Liu L#, Li S, Gao L, Zhao Y, Kim YJ, Chen X. 2016. SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. Nucleic Acids Res. 44(2): 608-620 (#Co-first author)
Zhao Q, Gao C, Lee P, Liu L, Li Shaofang, Hu T, Shen J, Pan S, Ye H, Chen Y, Cao W, Cui Y, Zeng P, Yu S, Gao Y, Chen L, Mo B, Liu X, Xiao S, Zhao Y, Zhong S, Chen X, Jiang L. 2015. Fast-suppressor screening for new components in protein trafficking, organelle biogenesis and silencing pathway in Arabidopsis thaliana using DEX-inducible FREE1-RNAi plants. J Genet Genomics. 42(6): 319-330
Huang Y, Kendall T, Forsythe ES, Dorantes-Acosta A, Li Shaofang, Caballero-Pérez J, Chen X, Arteaga-Vázquez M, Beilstein MA, Mosher RA. 2015. Ancient origin and recent innovations of RNA Polymerase IV and V. Mol Biol Evol. 32(7): 1788-1799
Li Shaofang, Lee EV, Tu B, Gao L, Won SY, Li S, Zheng B, Gregory BD, Chen X. 2015. Detection of Pol IV/RDR2-dependent transcripts at the genomic scale in Arabidopsis reveals features and regulation of siRNA biogenesis. Genome Res. 25(2): 235-245
Dinh TT, Gao L, Liu X, Li D, Li S, Zhao Y, O'Leary M, Le B, Schmitz RJ, Manavella P, Li Shaofang et al. 2014. DNA Topoisomerase 1 alpha promotes transcriptional silencing of transposable elements through DNA methylation and histone lysine 9 dimethylation in Arabidopsis. Plos Genet. 10(7): e1005452
Dinh TT, Luscher E, Li Shaofang, Liu X, Won SY, Chen X. 2014. Genetic screens for floral mutants in Arabidopsis thaliana: enhancers and suppressors. Methods in molecular biology 1110: 127-156
Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H, Li X, Li Shaofang et al. 2012. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science 336(6087): 1445-1448
Zhou H, Li Shaofang, Deng Z, Wang X, Chen T, Zhang J, Chen S, Ling H, Zhang A, Wang D et al. 2007. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in the wheat hypersensitive response to stripe rust fungus infection. Plant J 52(3): 420-434
Li Shaofang, Zhou H, Li L, Wang X, Zhang X. 2007. Isolation and characterization of High-Molecular-Weight glutenin subunit genes in Agropyron cristatum. Acta Agronomica Sinica 33(1): 63-69