个人简历

2005/6 - 至 今 ：中国农业大学，生物学院，教授，博士生导师
2003/1 - 2005/6 ：芬兰OrionPharma生物制药公司，R & D，研究员，负责临床前乳腺癌和前列腺癌药物研发。
1998/5 - 2003/5 ：芬兰Hormos生物制药公司，R & D，助理研究员，参加临床前乳腺癌和前列腺癌药物研发。
1997/1 - 1998/4 ：芬兰Gallius生物制药公司，R & D，助理研究员，参加临床前乳腺癌和前列腺癌药物研发。
1990/9 - 1993/12：中国科学院遗传研究所，实习研究员
1998/9 - 2002/5： 芬兰图尔库大学医学院，生理学， 博士
1996/3 - 1998/3 ：芬兰图尔库大学理学院，生物化学，硕士
1994/5 - 1996/12： 芬兰赫尔辛基大学，生物学，硕士研究生
1986/9 - 1990/6：北京农学院，学士
课题项目
1. 重点研发计划“精子发生过程中生殖细胞-支持细胞的糖脂代谢偶联及功能研究”（2019-2021）课题组长
2. 国家自然科学基金“受环境内分泌干扰物调控的Net49参与精子发生的分子机理” (2020 - 2023) 主持
3. 北京市自然科学基金 “ BPA/DEHP干扰RBP导致精子发生障碍的分子机理”(2020-2022) 主持
4. 中国人民解放军军事科计委员会项目：（涉密项目，题目略）主持
5. 汉义生物制药合作项目（2017-2020）：大麻二酚药效分析 主持

研究领域

内分泌失调引起代谢综合征 （糖尿病、脂肪肝等）；内分泌失调和环境因素引起不育发生的分子机制；内分泌相关的癌症发生（乳腺癌、卵巢癌和前列腺癌）机理和药物的筛选和研发。""

近期论文

Wang, M., W. Yu, J. Gao, W. Ma, M. Frentsch, A. Thiel, M. Liu, N. Rahman, Z. Qin, and Li X*, MicroRNA-487a-3p functions as a new tumor suppressor in prostate cancer by targeting CCND1. J Cell Physiol, 2020. 235(2): p. 1588-1600.
Liu, H., M. Liu, H. You, X. Li, and Li X*, Oncogenic Network and Hub Genes for Natural Killer/T-Cell Lymphoma Utilizing WGCNA. Front Oncol, 2020. 10: p. 223.
Zheng, H., Li, H., Zhang, J., Fan, H., Jia, L., Ma, W., Ma, S., Wang, S., You, H., Yin, Z., & Li, X. (2020). Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against Staphylococcus aureus cutaneous infection. The Journal of biological chemistry, 295(9), 2570–2581.
Zhang, J., X. Lu, M. Liu, H. Fan, H. Zheng, S. Zhang, N. Rahman, S. Wolczynski, A. Kretowski, and Li X*, Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension. Cardiovasc Res, 2019.
X, R. and Li X*. sciences, Advances in Research on Diabetes by Human Nutriomics. 2019. 20(21).
Liu, M., Du, Y., Li, H., Wang, L., Ponikwicka-Tyszko, D., Lebiedzinska, W., Pilaszewicz-Puza, A., Liu, H., Zhou, L., Fan, H., Wang, M., You, H., Wolczynnski, S., Rahman, N., Guo, Y. D., & Li, X*. (2019). Cyanidin-3-o-Glucoside Pharmacologically Inhibits Tumorigenesis via Estrogen Receptor β in Melanoma Mice. Frontiers in oncology, 9, 1110.
Wang, M., Sun, J., Xu, B., Chrusciel, M., Gao, J., Bazert, M., Stelmaszewska, J., Xu, Y., Zhang, H., Pawelczyk, L., Sun, F., Tsang, S. Y., Rahman, N., Wolczynski, S., & Li, X*. (2018). Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome. Endocrinology, 159(1), 297–309.
Fan, H., Du, X., Zhang, J., Zheng, H., Lu, X., Wu, Q., Li, H., Wang, H., Shi, Y., Gao, G., Zhou, Z., Tan, D. X., & Li, X. 2017. Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium. Sci Rep, 7: 41226.
Wenqiang Ma,a, Shi-Hua Li,b, Shuoqian Ma,a Lina Jia,a, Fuchun　Zhang,c Yong Zhang,a Jingyuan Zhang,a Yuhai Bib,Gary Wongb, Shanhan　Zhang a, Xuancheng Lu,d Hongwen Zhang,e Wei Li,f Daishu Han,g N Wang, C Qin X Li* and G F Gao, * Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice. Cell. 2017 Jan 26;168(3):542.
Wang, M., M. Liu, J. Sun, L. Jia, S. Ma, J. Gao, Y. Xu, H. Zhang, S.Y. Tsang, and Li X*, MicroRNA-27a-3p affects estradiol and androgen imbalance by targeting Creb1 in the granulosa cells in mouse polycytic ovary syndrome model. Reprod Biol, 2017. 17(4): p. 295-304.
Li, X*., Ma, W., Wong, G., Ma, S., Li, S., Bi, Y., & Gao, G. F. (2018). A new threat to human reproduction system posed by Zika virus (ZIKV): From clinical investigations to experimental studies. Virus research, 254, 10–14. https://doi.org/10.1016/j.virusres.2017.09.005
Yao, J., Zuo, H., Gao, J., Wang, M., Wang, D., & Li, X*. (2017). The effects of IGF-1 on mouse spermatogenesis using an organ culture method. Biochemical and biophysical research communications, 491(3), 840–847.
Liu Y, Sun J, Zhang H, Wang M, Gao F George, Li X*. Ebola virus encodes a miR-155 analog to regulate importin-1 α5 expression. Cell Mol Life Sci. 2016.
Li X*, Li H, Jia L, Li X, Rahman N. Oestrogen action and male fertility: experimental and clinical findings. Cell Mol Life Sci. 2015 Oct;72 (20): 3915-30.
X Li*, Y Liu, H Zhang, L Ren, Q Li, N Li. (2011) Animal models for the atherosclerosis research: a review. Protein Cell. 2(3):189-201.
Li X* and Rahman N (2010) Estrogens and bladder outlet obstruction. J Steroid Biochem Mol Biol.28:257-263
Li X* (2010) Aromatase over expression transgenic murine models for aromatase inhibitor studies. Molecular Human Reproduction. 160:80-6.
Li X* and Rahman N (2008) Impact of androgen/estrogen ratio: Lessons learned from the aromatase overexpression mice. General and Comparative Endocrinology. 159(1):1-9
Yongli Qin, Haifeng Li, Lina Jia, Jinghua Yan, George Fu Gao & Xiangdong Li*. Targeted disruption of Noc4l leads to preimplantation embryonic lethality in mice. Protein Cell. 2017 Mar;8(3):230-235. doi: 10.1007/s13238-016-0335-9
Li Wang 1, 2, Xiru Li3, Mei Liu3, Wenqiang Ma1, Shichao Guo1, Shiping Yang1, Jun Zhan4, Hongquan Zhang4, Suk Ying Tsang5, Ziding Zhang1, Zhaoyi Wang6*, Yangdong Guo2*, Xiangdong Li1*. Cyanidin-3-o- glucoside directly binds to the ligand-binding domain of ERα36 inhibiting EGFR-positive triple negative breast cancer. Oncotarget. 2016 Oct 18;7(42):68864-68882. doi: 10.18632/oncotarget.12025
Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao George F, Ward PA, Tan DX, Li X*. Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. J Pineal Res. 2016 Feb 17. doi: 10.1111/jpi.12322b
Yu W, Zheng H, Lin W, Tajima A, Zhang Y, Zhang X, Zhang H, Wu J, Han D, Rahman NA, Korach KS, Gao GF, Inoue I, Li X*. Estrogen promotes Leydig cell engulfment by macrophages in male infertility. J Clin Invest. 2014 2;124 (6):2709-21.
Zhang H, Liu Y, Wang L, Li Z, Zhang H, Wu J, Rahman N, Guo Y, Li D, Li N, Huhtaniemi I, Tsang SY, Gao GF, Li X*. Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat. J Lipid Res. 2013; 54(2):345-57.
Lin W, Rahman NA, Lin J, Zhang H, Gou K, Yu W, Zhu D, Li N, HuhtaniemiI, Li X*. (2011) Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol. 178 (3):1233-44.
X Li*, Y Liu, H Zhang, L Ren, Q Li, N Li. (2011) Animal models for the atherosclerosis research: a review. Protein Cell. 2(3):189-201.