个人简历

1982年9月--1987年7月北京农业大学动物医学院 学士
1987年7月--1990年7月北京农业大学动物医学院 硕士（传染病）
1990年7月--1993年7月 北京农业大学动物医学院 助教
1993年8月--1995年12月 美国Iowa State University 硕士（免疫学）
1996年1月--1999年12月美国North Carolina state University 博士（免疫学）
2000年1月--2003年7月美国University of North Carolina 医学院博士后
2003年8月--2007年3月，美国University of North Carolina 医学院 Senior Scientist
2007年3月--(原北京农业大学)教授

研究领域

分子病毒学与免疫学

近期论文

Liu Y, Du Y, Wang H, Du L, andWen-hai Feng*. 2017. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-8 expression through TAK-1/JNK/AP-1 pathways. Virology. 506:64-72
2.Liu F, Du Y, andWen-hai Feng*. 2017. New perspective of host microRNAs in the control of PRRSV infection. Vet Microbiology. S0378-1135(16)30612-5.
Yu Z, Huang C, Zhang Q, and Wen-hai Feng*. 2016. Porcine reproductive and respiratory syndrome virus (PRRSV) induces IL-12p40 production through JNK-AP-1 and NF-κB signaling pathways. Virus Res. 225:73-81
Du L, Liu Y, Du Y, Wang H, Zhang M, Du Y, and Wen-hai Feng*.2016. Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-15 through PKCβ1-TAK1-NF-κB signaling pathway. Virology 496:166-74.
Huang C, Du Y, Yu Z, Zhang Q, Liu Y, Tang J, Shi J, and Wen-hai Feng*. 2016. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Nsp4 Cleaves VISA to Impair Antiviral Responses Mediated by RIG-I-like Receptors. Scientific Reports 6:28497
Zhang Q, Huang C, Yang Q, Gao L, Liu HC, Tang J, and Wen-hai Feng*. 2016. MicroRNA-30c Modulates Type I IFN Responses To Facilitate Porcine Reproductive and Respiratory Syndrome Virus Infection by Targeting JAK1. Journal of Immunology 196(5):2272-82.
Gao L, Wang L, Huang C, Yang L, Guo XK, Yu Z, Liu Y, Yang P, and Wen-hai Feng*. 2015. HP-PRRSV is attenuated by de-optimization of codon pair bias in its RNA-dependent RNA polymerase nsp9 gene. Virology485:135-44.
Yang Q, Zhang Q, Tang J, and Wen-hai Feng*. 2015. Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection. Virology 484:170-180.
Huang C, Zhang Q, and Wen-hai Feng*. 2014. Regulation and evasion of antiviral immune responses by porcine reproductive and respiratorysyndrome virus.Virus Res. 202:101-11.
Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, and Wen-hai Feng*. 2014. Attenuation of highly pathogenic porcine reproductive and respiratory syndrome virus by inserting an additional transcription unit. Vaccine 32(43):5740-8.
Huang C, Zhang Q, Guo XK, Yu ZB, Xu AT, Tang J, and Wen-hai Feng*. 2014. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes IFNbeta Expression by Targeting NEMO. Journal of virology88(18): 10934-10945.
Zhao H, Guo XK, Bi Y, Zhu Y, and Wen-hai Feng*. 2014. PKCσ is required for porcine reproductive and respiratory syndrome virus replication. Virology 468-470:96-103.
Chen XX, Quan R, Guo XK, Gao L, Shi J, and Wen-hai Feng*. 2014. Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: implications for HP-PRRSV neuropathogenesis. Vet Microbiol. 170(1-2):48-57.
Zhang Q, Guo XK, Gao L, Huang C, Li N, Jia X, Liu W, and Wen-hai Feng*. 2014. MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons. Virology 450-451:182-95.
Zhao H, Wang Y, Ma Z, Wang Y, and Wen-hai Feng*. 2014. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 15(2):199-208.
Bi Y, Guo XK, Zhao H, Gao L, Wang L, Tang J, and Wen-hai Feng*. 2014. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Prostaglandin E2 Production through Cyclooxygenase 1, Which Is Dependent on the ERK1/2-p-C/EBP-β Pathway. Journal of Virology 88(5):2810-20.
Ma Z, Zhang W, Wang L, Zhu M, Wang H, and Wen-hai Feng*, Ng TB. 2013. A novel compound from the mushroom Cryptoporus volvatus inhibits porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. PLoS One 8(11):e79333.
Ma Z, Wang Y, Zhao H, Xu AT, Wang Y, Tang J, and Wen-hai Feng*. 2013.Porcine reproductive and respiratory syndrome virus nonstructural protein 4 induces apoptosis dependent on its 3C-like serine protease activity. PLoS One8(7):e69387.
Wang Y, Zhao H, Ma Z, Wang Y, and Wen-hai Feng*. 2013.CTLA4 mediated targeting enhances immunogenicity against PRRSV in a DNA prime/killed virus boost strategy. Vet Immunol Immunopathol. 154(3-4):121-8.
Gao L, Guo XK, Wang L, Zhang Q, Li N, Chen XX, Wang Y, and Wen-hai Feng*. 2013. MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163. Journal of Virology 87(15):8808-12.